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Reviewed, UniProtKB/Swiss-Prot Q9Z9F4 (LON_CHLPN)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    ATP-dependent protease La
    EC=3.4.21.53
Gene names
Name: lon
Ordered Locus Names: CPn_0027, CP_0749, CpB0031
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydophila

Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Degrades short-lived regulatory and abnormal proteins in presence of ATP. Hydrolyzes two ATPs for each peptide bond cleaved in the protein substrate By similarity.

Catalytic activity

Hydrolysis of proteins in presence of ATP.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 819819ATP-dependent protease La
PRO_0000076131

Regions

Domain42 – 238197Lon
Nucleotide binding393 – 4008ATP Potential

Sites

Active site7231 By similarity
Active site7661 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z9F4-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 788BCB2A0D294E6A

FASTA81992,276
        10         20         30         40         50         60 
MDSTTNSDSP ILDPNPEDVE KLLDESEEES EDQSTERLLP SELFILPLNK RPFFPGMAAP 

        70         80         90        100        110        120 
ILIESGPYYE VLKVLAKSSQ KYIGLVLTKK ENADILKVSF NQLHKTGVAA RILRIMPIEG 

       130        140        150        160        170        180 
GSAQVLLSIE ERIRIIEPIK DKYLKARVSY HADNKELTEE LKAYSISIVS VIKDLLKLNP 

       190        200        210        220        230        240 
LFKEELQIFL GHSDFTEPGK LADFSVALTT ATREELQEVL ETTNMHDRID KALILLKKEL 

       250        260        270        280        290        300 
DLSRLQSSIN QKIEATITKS QKEFFLKEQL KTIKKELGLE KEDRAIDIEK FSERLRKRHV 

       310        320        330        340        350        360 
PDYAMEVIQD EIEKLQTLET SSAEYTVCRN YLDWLTIIPW GIQSKEYHDL KKAEIVLNKD 

       370        380        390        400        410        420 
HYGLDEIKQR ILELISVGKL SKGLKGSIIC LVGPPGVGKT SIGRSIAKVL HRKFFRFSVG 

       430        440        450        460        470        480 
GMRDEAEIKG HRRTYIGAMP GKMVQALKQS QAMNPVIMID EVDKIGASYH GDPASALLEV 

       490        500        510        520        530        540 
LDPEQNKDFL DHYLDVRVDL SNVLFILTAN VLDTIPDPLL DRMEILRLSG YILEEKLQIA 

       550        560        570        580        590        600 
KKYLVPKARK EIGLTASEVN FQPEALKYMI NNYAREAGVR TLNGNIKKVL RKVALKIVQN 

       610        620        630        640        650        660 
QEKPKSKKIT FKISSKNLQT YLGKPIFSSD RFYESTPVGV ATGLAWTSLG GATLYIESVQ 

       670        680        690        700        710        720 
VSSLKTDMHL TGQAGEVMKE SSQIAWTYLH SALHRYAPGY TFFPKSQVHI HIPEGATPKD 

       730        740        750        760        770        780 
GPSAGITMVT SLLSLLLETP VVNNLGMTGE ITLTGRVLGV GGIREKLIAA RRSRLNILIF 

       790        800        810 
PEDNRRDYEE LPAYLKTGLK IHFVSHYDDV LKVAFPKLK 

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

AE001363 Genomic DNA. Translation: AAD18180.1.
AE002161 Genomic DNA. Translation: AAF38554.1.
BA000008 Genomic DNA. Translation: BAA98239.1.
AE017157 Genomic DNA. Translation: AAP97964.1.
PIRB72128.
E86494.
RefSeqNP_224235.1.
NP_300088.1.
NP_445291.1.
NP_876307.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSS16.002.

Genome annotation databases

GeneID1466714.
894928.
918819.
963156.
GenomeReviewsGene locus CPn_0027 in contig AE001363_GR.
Gene locus CP_0749 in contig AE002161_GR.
Gene locus CpB0031 in contig AE009440_GR.
Gene locus lon in contig BA000008_GR.
KEGGcpa:CP0749.
cpn:CPn0027.
cpt:CpB0031.
TIGRCP_0749.

Phylogenomic databases

HOGENOMQ9Z9F4.
OMAQ9Z9F4. WGNYSDE.

Enzyme and pathway databases

BioCycCPNE115711:CP_0749-MON.
CPNE115713:CPN0027-MON.
CPNE138677:CPJ0027-MON.
CPNE182082:CPB0031-MON.
BRENDA3.4.21.53. 264832.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR008269. Pept_S16_C.
IPR004815. Pept_S16_lon.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR001984. Peptidase_S16_C.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PRINTSPR00830. ENDOLAPTASE.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
TIGRFAMsTIGR00763. lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_CHLPN
AccessionPrimary (citable) accession number: Q9Z9F4
Secondary accession number(s): Q9JQ69
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents