Q9Z9F4 (LON_CHLPN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 98.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Lon protease EC=3.4.21.53 Alternative name(s): ATP-dependent protease La | ||||
| Gene names |
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| Organism | Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83558 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia![]() |
Protein attributes
| Sequence length | 819 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity. HAMAP-Rule MF_01973 |
| Catalytic activity | Hydrolysis of proteins in presence of ATP. HAMAP-Rule MF_01973 |
| Subunit structure | Homohexamer. Organized in a ring with a central cavity By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Induction | By heat shock By similarity. |
| Sequence similarities | Belongs to the peptidase S16 family. Contains 1 Lon domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase Protease Serine protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | misfolded or incompletely synthesized protein catabolic process Inferred from electronic annotation. Source: InterPro response to stressInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activityInferred from electronic annotation. Source: InterPro serine-type endopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029. |
| [2] | "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. Fraser C.M.Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39. |
| [3] | "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138. |
| [4] | "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001363 Genomic DNA. Translation: AAD18180.1. AE002161 Genomic DNA. Translation: AAF38554.1. BA000008 Genomic DNA. Translation: BAA98239.1. AE009440 Genomic DNA. Translation: AAP97964.1. |
| PIR | B72128. E86494. |
| RefSeq | NP_224235.1. NC_000922.1. NP_300088.1. NC_002491.1. NP_445291.1. NC_002179.2. NP_876307.1. NC_005043.1. |
3D structure databases | |
| ProteinModelPortal | Q9Z9F4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 115713.CPn0027. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAD18180; AAD18180; CPn_0027. AAF38554; AAF38554; CP_0749. AAP97964; AAP97964; CpB0031. BAA98239; BAA98239; BAA98239. |
| GeneID | 1466714. 894928. 918819. 963156. |
| KEGG | cpa:CP0749. cpj:CPj0027. cpn:CPn0027. cpt:CpB0031. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0466. |
| HOGENOM | HOG000261409. |
| KO | K01338. |
| OMA | FFILTAN. |
| ProtClustDB | CLSK2459232. |
Enzyme and pathway databases | |
| BioCyc | CPNE115711:GI7B-747-MONOMER. CPNE115713:GHEY-30-MONOMER. CPNE138677:GH8N-26-MONOMER. CPNE182082:GH4N-32-MONOMER. |
Family and domain databases | |
| Gene3D | 3.30.230.10. 1 hit. |
| HAMAP | MF_01973. lon_bact. |
| InterPro | IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR027065. Lon_Prtase. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR015947. PUA-like_domain. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view] |
| PANTHER | PTHR10046. PTHR10046. 1 hit. |
| Pfam | PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF001174. Lon_proteas. 1 hit. |
| SMART | SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view] |
| SUPFAM | SSF88697. PUA-like. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. |
| TIGRFAMs | TIGR00763. lon. 1 hit. |
| PROSITE | PS01046. LON_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LON_CHLPN | ||||||||
| Accession | Primary (citable) accession number: Q9Z9F4 Secondary accession number(s): Q9JQ69 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with
