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Q9Z9C7

- RNC_CHLPN

UniProt

Q9Z9C7 - RNC_CHLPN

Protein

Ribonuclease 3

Gene

rnc

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Mg2+.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi48 – 481MagnesiumUniRule annotation
    Active sitei52 – 521UniRule annotation
    Metal bindingi121 – 1211MagnesiumUniRule annotation
    Active sitei124 – 1241UniRule annotation
    Metal bindingi124 – 1241MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-746-MONOMER.
    CPNE115713:GHEY-54-MONOMER.
    CPNE138677:GH8N-55-MONOMER.
    CPNE182082:GH4N-55-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Short name:
    RNase IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotation
    Ordered Locus Names:CPn_0054, CP_0721, CpB0055
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Ribonuclease 3PRO_0000180387Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn0054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z9C7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 135129RNase IIIUniRule annotationAdd
    BLAST
    Domaini160 – 22970DRBMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
    Contains 1 RNase III domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0571.
    HOGENOMiHOG000246808.
    KOiK03685.
    OMAiTFKDQEL.
    OrthoDBiEOG6T1WVS.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF00636. Ribonuclease_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z9C7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPPIDITAI EAKLNFTFTQ PKLLEIALTH PSYKNESAVQ IEDSERLEFL    50
    GDAVLGLIVT EHLFLLFPSM DEGTLSTARA SLVNAKACCR YTTMLGIGDY 100
    LLIGKGEKIQ SERGRLSAYA NLFESILGAV YLDGGLSPAR KLTVPLLPPR 150
    EEILPLMSGN PKNLLQQFTQ KQFRVLPVYQ STAVTDAQGN VSYQIQVLVN 200
    QEVWGEGNAS SKKEAEKIAA QQALDTYGNK NQNTMDV 237
    Length:237
    Mass (Da):26,088
    Last modified:May 1, 1999 - v1
    Checksum:iEF9E79A5739EDAAE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941M → V in AAP97988. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18207.1.
    AE002161 Genomic DNA. Translation: AAF38526.1.
    BA000008 Genomic DNA. Translation: BAA98265.1.
    AE009440 Genomic DNA. Translation: AAP97988.1.
    PIRiD72126.
    G86497.
    RefSeqiNP_224262.1. NC_000922.1.
    NP_300114.1. NC_002491.1.
    NP_445263.1. NC_002179.2.
    NP_876331.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18207; AAD18207; CPn_0054.
    AAF38526; AAF38526; CP_0721.
    AAP97988; AAP97988; CpB0055.
    BAA98265; BAA98265; BAA98265.
    GeneIDi1466738.
    895023.
    918843.
    963180.
    KEGGicpa:CP0721.
    cpj:CPj0054.
    cpn:CPn0054.
    cpt:CpB0055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18207.1 .
    AE002161 Genomic DNA. Translation: AAF38526.1 .
    BA000008 Genomic DNA. Translation: BAA98265.1 .
    AE009440 Genomic DNA. Translation: AAP97988.1 .
    PIRi D72126.
    G86497.
    RefSeqi NP_224262.1. NC_000922.1.
    NP_300114.1. NC_002491.1.
    NP_445263.1. NC_002179.2.
    NP_876331.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z9C7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18207 ; AAD18207 ; CPn_0054 .
    AAF38526 ; AAF38526 ; CP_0721 .
    AAP97988 ; AAP97988 ; CpB0055 .
    BAA98265 ; BAA98265 ; BAA98265 .
    GeneIDi 1466738.
    895023.
    918843.
    963180.
    KEGGi cpa:CP0721.
    cpj:CPj0054.
    cpn:CPn0054.
    cpt:CpB0055.

    Phylogenomic databases

    eggNOGi COG0571.
    HOGENOMi HOG000246808.
    KOi K03685.
    OMAi TFKDQEL.
    OrthoDBi EOG6T1WVS.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-746-MONOMER.
    CPNE115713:GHEY-54-MONOMER.
    CPNE138677:GH8N-55-MONOMER.
    CPNE182082:GH4N-55-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF00636. Ribonuclease_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiRNC_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z9C7
    Secondary accession number(s): Q9JQ21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3