Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Z9C2

- DUT_CHLPN

UniProt

Q9Z9C2 - DUT_CHLPN

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761SubstrateUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-741-MONOMER.
    CPNE115713:GHEY-59-MONOMER.
    CPNE138677:GH8N-60-MONOMER.
    CPNE182082:GH4N-60-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:CPn_0059, CP_0716, CpB0060
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182846Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0059.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z9C2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 653Substrate bindingUniRule annotation
    Regioni80 – 823Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028966.
    KOiK01520.
    OMAiIVCELES.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z9C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVFCELDSG GELPEYTTPG AAGADLRANI EEPIALLPGQ RALIPTGIKA    50
    EIPEGYELQV RPRSGLALKH GITVLNSPGT IDSDYRGEIR VILINFGDST 100
    FIIEPKMRIA QVVLSPVVQA TFVVKQESLA ETARGSGGFG HTGAS 145
    Length:145
    Mass (Da):15,347
    Last modified:May 1, 1999 - v1
    Checksum:i025E5B34DF488A83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18212.1.
    AE002161 Genomic DNA. Translation: AAF38522.1.
    BA000008 Genomic DNA. Translation: BAA98270.1.
    AE009440 Genomic DNA. Translation: AAP97993.1.
    PIRiD72124.
    D86498.
    RefSeqiNP_224267.1. NC_000922.1.
    NP_300119.1. NC_002491.1.
    NP_445258.1. NC_002179.2.
    NP_876336.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18212; AAD18212; CPn_0059.
    AAF38522; AAF38522; CP_0716.
    AAP97993; AAP97993; CpB0060.
    BAA98270; BAA98270; BAA98270.
    GeneIDi1466743.
    894712.
    918848.
    963183.
    KEGGicpa:CP0716.
    cpj:CPj0059.
    cpn:CPn0059.
    cpt:CpB0060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18212.1 .
    AE002161 Genomic DNA. Translation: AAF38522.1 .
    BA000008 Genomic DNA. Translation: BAA98270.1 .
    AE009440 Genomic DNA. Translation: AAP97993.1 .
    PIRi D72124.
    D86498.
    RefSeqi NP_224267.1. NC_000922.1.
    NP_300119.1. NC_002491.1.
    NP_445258.1. NC_002179.2.
    NP_876336.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z9C2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18212 ; AAD18212 ; CPn_0059 .
    AAF38522 ; AAF38522 ; CP_0716 .
    AAP97993 ; AAP97993 ; CpB0060 .
    BAA98270 ; BAA98270 ; BAA98270 .
    GeneIDi 1466743.
    894712.
    918848.
    963183.
    KEGGi cpa:CP0716.
    cpj:CPj0059.
    cpn:CPn0059.
    cpt:CpB0060.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028966.
    KOi K01520.
    OMAi IVCELES.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci CPNE115711:GI7B-741-MONOMER.
    CPNE115713:GHEY-59-MONOMER.
    CPNE138677:GH8N-60-MONOMER.
    CPNE182082:GH4N-60-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiDUT_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z9C2
    Secondary accession number(s): Q9JQD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3