Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z9C2

- DUT_CHLPN

UniProt

Q9Z9C2 - DUT_CHLPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761SubstrateUniRule annotation

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-741-MONOMER.
CPNE115713:GHEY-59-MONOMER.
CPNE138677:GH8N-60-MONOMER.
CPNE182082:GH4N-60-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:CPn_0059, CP_0716, CpB0060
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0059.

Structurei

3D structure databases

ProteinModelPortaliQ9Z9C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 653Substrate bindingUniRule annotation
Regioni80 – 823Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028966.
KOiK01520.
OMAiIVCELES.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z9C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVFCELDSG GELPEYTTPG AAGADLRANI EEPIALLPGQ RALIPTGIKA
60 70 80 90 100
EIPEGYELQV RPRSGLALKH GITVLNSPGT IDSDYRGEIR VILINFGDST
110 120 130 140
FIIEPKMRIA QVVLSPVVQA TFVVKQESLA ETARGSGGFG HTGAS
Length:145
Mass (Da):15,347
Last modified:May 1, 1999 - v1
Checksum:i025E5B34DF488A83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18212.1.
AE002161 Genomic DNA. Translation: AAF38522.1.
BA000008 Genomic DNA. Translation: BAA98270.1.
AE009440 Genomic DNA. Translation: AAP97993.1.
PIRiD72124.
D86498.
RefSeqiNP_224267.1. NC_000922.1.
NP_300119.1. NC_002491.1.
NP_445258.1. NC_002179.2.
NP_876336.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18212; AAD18212; CPn_0059.
AAF38522; AAF38522; CP_0716.
AAP97993; AAP97993; CpB0060.
BAA98270; BAA98270; BAA98270.
GeneIDi1466743.
894712.
918848.
963183.
KEGGicpa:CP0716.
cpj:CPj0059.
cpn:CPn0059.
cpt:CpB0060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18212.1 .
AE002161 Genomic DNA. Translation: AAF38522.1 .
BA000008 Genomic DNA. Translation: BAA98270.1 .
AE009440 Genomic DNA. Translation: AAP97993.1 .
PIRi D72124.
D86498.
RefSeqi NP_224267.1. NC_000922.1.
NP_300119.1. NC_002491.1.
NP_445258.1. NC_002179.2.
NP_876336.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z9C2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18212 ; AAD18212 ; CPn_0059 .
AAF38522 ; AAF38522 ; CP_0716 .
AAP97993 ; AAP97993 ; CpB0060 .
BAA98270 ; BAA98270 ; BAA98270 .
GeneIDi 1466743.
894712.
918848.
963183.
KEGGi cpa:CP0716.
cpj:CPj0059.
cpn:CPn0059.
cpt:CpB0060.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028966.
KOi K01520.
OMAi IVCELES.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci CPNE115711:GI7B-741-MONOMER.
CPNE115713:GHEY-59-MONOMER.
CPNE138677:GH8N-60-MONOMER.
CPNE182082:GH4N-60-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiDUT_CHLPN
AccessioniPrimary (citable) accession number: Q9Z9C2
Secondary accession number(s): Q9JQD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3