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Q9Z9A7

- EFTU_CHLPN

UniProt

Q9Z9A7 - EFTU_CHLPN

Protein

Elongation factor Tu

Gene

tuf

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi136 – 1394GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-724-MONOMER.
    CPNE115713:GHEY-76-MONOMER.
    CPNE138677:GH8N-76-MONOMER.
    CPNE182082:GH4N-76-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotation
    Synonyms:tufA
    Ordered Locus Names:CPn_0074, CP_0701, CpB0074
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 394393Elongation factor TuPRO_0000091307Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z9A7.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn0074.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z9A7.
    SMRiQ9Z9A7. Positions 2-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 204195tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 268G1By similarity
    Regioni60 – 645G2By similarity
    Regioni81 – 844G3By similarity
    Regioni136 – 1394G4By similarity
    Regioni174 – 1763G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiGTEMCMP.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z9A7-1 [UniParc]FASTAAdd to Basket

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    MSKETFQRNK PHINIGTIGH VDHGKTTLTA AITRALSGDG LASFRDYSSI    50
    DNTPEEKARG ITINASHVEY ETPNRHYAHV DCPGHADYVK NMITGAAQMD 100
    GAILVVSATD GAMPQTKEHI LLARQVGVPY IVVFLNKVDM ISQEDAELID 150
    LVEMELSELL EEKGYKGCPI IRGSALKALE GDANYIEKVR ELMQAVDDNI 200
    PTPEREIDKP FLMPIEDVFS ISGRGTVVTG RIERGIVKVS DKVQLVGLGE 250
    TKETIVTGVE MFRKELPEGR AGENVGLLLR GIGKNDVERG MVVCQPNSVK 300
    PHTKFKSAVY VLQKEEGGRH KPFFSGYRPQ FFFRTTDVTG VVTLPEGTEM 350
    VMPGDNVELD VELIGTVALE EGMRFAIREG GRTIGAGTIS KINA 394
    Length:394
    Mass (Da):43,136
    Last modified:January 23, 2007 - v3
    Checksum:i1463A200385BC4FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18227.1.
    AE002161 Genomic DNA. Translation: AAF38509.1.
    BA000008 Genomic DNA. Translation: BAA98284.1.
    AE009440 Genomic DNA. Translation: AAP98007.1.
    PIRiB86500.
    F72123.
    RefSeqiNP_224282.1. NC_000922.1.
    NP_300133.1. NC_002491.1.
    NP_445243.1. NC_002179.2.
    NP_876350.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18227; AAD18227; CPn_0074.
    AAF38509; AAF38509; CP_0701.
    AAP98007; AAP98007; CpB0074.
    BAA98284; BAA98284; BAA98284.
    GeneIDi1466757.
    894749.
    918864.
    963722.
    KEGGicpa:CP0701.
    cpj:CPj0074.
    cpn:CPn0074.
    cpt:CpB0074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18227.1 .
    AE002161 Genomic DNA. Translation: AAF38509.1 .
    BA000008 Genomic DNA. Translation: BAA98284.1 .
    AE009440 Genomic DNA. Translation: AAP98007.1 .
    PIRi B86500.
    F72123.
    RefSeqi NP_224282.1. NC_000922.1.
    NP_300133.1. NC_002491.1.
    NP_445243.1. NC_002179.2.
    NP_876350.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z9A7.
    SMRi Q9Z9A7. Positions 2-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0074.

    Proteomic databases

    PRIDEi Q9Z9A7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18227 ; AAD18227 ; CPn_0074 .
    AAF38509 ; AAF38509 ; CP_0701 .
    AAP98007 ; AAP98007 ; CpB0074 .
    BAA98284 ; BAA98284 ; BAA98284 .
    GeneIDi 1466757.
    894749.
    918864.
    963722.
    KEGGi cpa:CP0701.
    cpj:CPj0074.
    cpn:CPn0074.
    cpt:CpB0074.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi GTEMCMP.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-724-MONOMER.
    CPNE115713:GHEY-76-MONOMER.
    CPNE138677:GH8N-76-MONOMER.
    CPNE182082:GH4N-76-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiEFTU_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z9A7
    Secondary accession number(s): Q9JQB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3