Q9Z9A5 (NUSG_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription antitermination protein nusG

Gene names

Name:	nusG
Ordered Locus Names:	CPn_0076, CP_0699, CpB0076

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Influences transcription termination and antitermination. Acts as a component of the transcription complex, and interacts with the termination factor rho and RNA polymerase By similarity.
Sequence similarities	Belongs to the nusG family. Contains 1 KOW domain.

Ontologies

Keywords
Biological process	Transcription Transcription antitermination Transcription regulation Transcription termination
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription elongation from RNA polymerase II promoter Inferred from electronic annotation. Source: InterPro transcription antitermination Inferred from electronic annotation. Source: UniProtKB-KW transcription termination, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Transcription antitermination protein nusG		PRO_0000113923
Regions
	Domain	121 – 158	38	KOW
Natural variations
	Natural variant	140	1	T → M in strain: CWL029 and TW-183.

Sequences

	Sequence		Length	Mass (Da)
	Q9Z9A5 [UniParc]. Last modified September 26, 2001. Version 2. Checksum: AD406EFB0F08095C	FASTA	182	20,792
	10 20 30 40 50 60 MYKWYVVQVF TAQEKKVKKA LEDFKESSGM TDFIQEIILP IENVMEVKKG EHKVVEKYIW 70 80 90 100 110 120 PGYLLVKMHL TDESWLYVKS TAGIVEFLGG GVPVALSEDE VRSILTDIEE KKSGVVQKHQ 130 140 150 160 170 180 FEVGSRVKIN DGVFVNFIGT VSEVFHDKGR LSVMVSIFGR ETRVDDLEFW QVEEVAPGQE SE

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[3]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18229.1. BA000008 Genomic DNA. Translation: BAA98286.1. AE002161 Genomic DNA. Translation: AAF38507.1. AE009440 Genomic DNA. Translation: AAP98009.1.
PIR	C81547. D86500. H72123.
RefSeq	NP_224284.1. NC_000922.1. NP_300135.1. NC_002491.1. NP_445241.1. NC_002179.2. NP_876352.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z9A5.
ModBase	Search...
2D gel databases
PHCI-2DPAGE	Q9Z9A5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1466759. 894692. 918867. 963204.
GenomeReviews	Gene locus CPn_0076 in contig AE001363_GR. Gene locus CP_0699 in contig AE002161_GR. Gene locus CpB0076 in contig AE009440_GR. Gene locus nusG in contig BA000008_GR.
KEGG	cpa:CP0699. cpn:CPn0076. cpt:CpB0076.
TIGR	CP_0699.
Phylogenomic databases
HOGENOM	HBG751162.
OMA	VASGCEK.
ProtClustDB	PRK05609.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0699-MONOMER. CPNE115713:CPN0076-MONOMER. CPNE138677:CPJ0076-MONOMER. CPNE182082:CPB0076-MONOMER.
Family and domain databases
InterPro	IPR005824. KOW. IPR001062. Transcrpt_antiterm_NusG. IPR006645. Transcrpt_antiterm_NusG_N. IPR014722. Transl_SH3-like_sub. IPR008991. Translation_prot_SH3-like. [Graphical view]
Gene3D	G3DSA:2.30.30.30. Ribosomal_L2. 1 hit. G3DSA:3.30.70.940. Transcrpt_antiterm_NusG_N. 1 hit.
KO	K02601.
Pfam	PF02357. NusG. 1 hit. [Graphical view]
PRINTS	PR00338. NUSGTNSCPFCT.
SMART	SM00739. KOW. 1 hit. SM00738. NGN. 1 hit. [Graphical view]
SUPFAM	SSF82679. Transcrpt_antiterm_NusG_N. 1 hit. SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMs	TIGR00922. NusG. 1 hit.
PROSITE	PS01014. NUSG. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUSG_CHLPN

Accession

Primary (citable) accession number: Q9Z9A5
Secondary accession number(s): Q9JRY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	September 26, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program