Q9Z986 (PKND_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PknD
EC=2.7.11.1

Gene names

Name:	pknD
Ordered Locus Names:	CPn_0095, CP_0679, CPj0095, CpB0095

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	932 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Together with the serine/threonine kinase pkn1, may play a role in the specific interactions with host proteins during intracellular growth By similarity. HAMAP-Rule MF_01957
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. HAMAP-Rule MF_01957
Post-translational modification	Autophosphorylated on serine and threonine residues By similarity. HAMAP-Rule MF_01957
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence AAD18248.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA98305.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP protein serine/threonine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 932	932	Serine/threonine-protein kinase PknD HAMAP-Rule MF_01957		PRO_0000171192
Regions
	Domain	4 – 291	288	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	138	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z986 [UniParc]. Last modified July 11, 2001. Version 2. Checksum: 47AAF87DF6CC5DF7	FASTA	932	107,410
	10 20 30 40 50 60 MERYDIVRII GKGGMGEVYL AYDPVCSRKV ALKKIREDLA ENPLLKRRFL REARIAADLI 70 80 90 100 110 120 HPGVVPVYTI YSEKDPVYYT MPYIEGYTLK TLLKSVWQKE SLSKELAEKT SVGAFLSIFH 130 140 150 160 170 180 KICCTIEYVH SRGILHRDLK PDNILLGLFS EAVILDWGAA VACGEEEDLL DIDVSKEEVL 190 200 210 220 230 240 SSRMTIPGRI VGTPDYMAPE RLLGHPASKS TDIYALGVVL YQMLTLSFPY RRKKGKKIVL 250 260 270 280 290 300 DGQRIPSPQE VAPYREIPPF LSAVVMRMLA VDPQERYSSV TELKEDIESH LKGSPKWTLT 310 320 330 340 350 360 TALPPKKSSS WKLNEPILLS KYFPMLEVSP ASWYSLAISN IESFSEMRLE YTLSKKGLNE 370 380 390 400 410 420 GFGILLPTSE NALGGDFYQG YGFWLHIKER TLSVSLVKNS LEIQRCSQDL ESDKETFLIA 430 440 450 460 470 480 LEQHNHSLSL FVDGTTWLIH MNYLPSRSGR VAIIVRDMED ILEDIGIFES SGSLRVSCLA 490 500 510 520 530 540 VPDAFLAEKL YDRALVLYRR IAESFPGRKE GYEARFRAGI TVLEKASTDN NEQEFALAIE 550 560 570 580 590 600 EFSKLHDGVA APLEYLGKAL VYQRLQEYNE EIKSLLLALK RYSQHPEIFR LKDHVVYRLH 610 620 630 640 650 660 ESFYKRDRLA LVFMILVLEI APQAITPGQE EKILVWLKDK SRATLFCLLD PTVLELRSSK 670 680 690 700 710 720 MELFLSYWSG FIPHLNSLFH RAWDQSDVRA LIEIFYVACD LHKWQFLSSC IDIFKESLED 730 740 750 760 770 780 QKATEEIVEF SFEDLGAFLF AIQSIFNKED AEKIFVSNDQ LSPILLVYIF DLFANRALLE 790 800 810 820 830 840 SQGEAIFQAL DLIRSKVPEN FYHDYLRNHE IRAHLWCRNE KALSTIFENY TEKQLKDEQH 850 860 870 880 890 900 ELFVLYGCYL ALIQGAEAAK QHFDVCREDR IFPASLLARN YNRLGLPKDA LSYQERRLLL 910 920 930 RQKFLYFHCL GNHDERDLCQ TMYHLLTEEF QL

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18248.1. Different initiation. AE002161 Genomic DNA. Translation: AAF73695.1. BA000008 Genomic DNA. Translation: BAA98305.1. Different initiation. AE009440 Genomic DNA. Translation: AAP98028.1.
PIR	C72120. G86502.
RefSeq	NP_224303.2. NC_000922.1. NP_300154.2. NC_002491.1. NP_445221.1. NC_002179.2. NP_876371.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z986.
ModBase	Search...
Protein-protein interaction databases
STRING	115713.CPn0095.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD18248; AAD18248; CPn_0095. AAF73695; AAF73695; CP_0679. AAP98028; AAP98028; CpB0095. BAA98305; BAA98305; BAA98305.
GeneID	1466778. 895704. 918839. 963217.
KEGG	cpa:CP0679. cpj:CPj0095. cpn:CPn0095. cpt:CpB0095.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000034686.
KO	K08884.
OMA	YQMLTLS.
ProtClustDB	PRK13184.
Enzyme and pathway databases
BioCyc	CPNE115711:GI7B-701-MONOMER. CPNE115713:GHEY-98-MONOMER. CPNE138677:GH8N-98-MONOMER. CPNE182082:GH4N-98-MONOMER.
Family and domain databases
HAMAP	MF_01957. PknD_kinase.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR023507. Ser/Thr_kinase_PknD. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKND_CHLPN

Accession

Primary (citable) accession number: Q9Z986
Secondary accession number(s): Q9K216

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	July 11, 2001
Last modified:	May 29, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program