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Protein

Serine/threonine-protein kinase PknD

Gene

pknD

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPUniRule annotation
Active sitei138 – 1381Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-701-MONOMER.
CPNE115713:GHEY-98-MONOMER.
CPNE138677:GH8N-98-MONOMER.
CPNE182082:GH4N-98-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknDUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:pknDUniRule annotation
Ordered Locus Names:CPn_0095, CP_0679, CPj0095, CpB0095
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000583 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Serine/threonine-protein kinase PknDPRO_0000171192Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0095.

Structurei

3D structure databases

ProteinModelPortaliQ9Z986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 291288Protein kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000034686.
KOiK08884.
OMAiSIFHKIC.
OrthoDBiEOG6W45P7.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERYDIVRII GKGGMGEVYL AYDPVCSRKV ALKKIREDLA ENPLLKRRFL
60 70 80 90 100
REARIAADLI HPGVVPVYTI YSEKDPVYYT MPYIEGYTLK TLLKSVWQKE
110 120 130 140 150
SLSKELAEKT SVGAFLSIFH KICCTIEYVH SRGILHRDLK PDNILLGLFS
160 170 180 190 200
EAVILDWGAA VACGEEEDLL DIDVSKEEVL SSRMTIPGRI VGTPDYMAPE
210 220 230 240 250
RLLGHPASKS TDIYALGVVL YQMLTLSFPY RRKKGKKIVL DGQRIPSPQE
260 270 280 290 300
VAPYREIPPF LSAVVMRMLA VDPQERYSSV TELKEDIESH LKGSPKWTLT
310 320 330 340 350
TALPPKKSSS WKLNEPILLS KYFPMLEVSP ASWYSLAISN IESFSEMRLE
360 370 380 390 400
YTLSKKGLNE GFGILLPTSE NALGGDFYQG YGFWLHIKER TLSVSLVKNS
410 420 430 440 450
LEIQRCSQDL ESDKETFLIA LEQHNHSLSL FVDGTTWLIH MNYLPSRSGR
460 470 480 490 500
VAIIVRDMED ILEDIGIFES SGSLRVSCLA VPDAFLAEKL YDRALVLYRR
510 520 530 540 550
IAESFPGRKE GYEARFRAGI TVLEKASTDN NEQEFALAIE EFSKLHDGVA
560 570 580 590 600
APLEYLGKAL VYQRLQEYNE EIKSLLLALK RYSQHPEIFR LKDHVVYRLH
610 620 630 640 650
ESFYKRDRLA LVFMILVLEI APQAITPGQE EKILVWLKDK SRATLFCLLD
660 670 680 690 700
PTVLELRSSK MELFLSYWSG FIPHLNSLFH RAWDQSDVRA LIEIFYVACD
710 720 730 740 750
LHKWQFLSSC IDIFKESLED QKATEEIVEF SFEDLGAFLF AIQSIFNKED
760 770 780 790 800
AEKIFVSNDQ LSPILLVYIF DLFANRALLE SQGEAIFQAL DLIRSKVPEN
810 820 830 840 850
FYHDYLRNHE IRAHLWCRNE KALSTIFENY TEKQLKDEQH ELFVLYGCYL
860 870 880 890 900
ALIQGAEAAK QHFDVCREDR IFPASLLARN YNRLGLPKDA LSYQERRLLL
910 920 930
RQKFLYFHCL GNHDERDLCQ TMYHLLTEEF QL
Length:932
Mass (Da):107,410
Last modified:July 11, 2001 - v2
Checksum:i47AAF87DF6CC5DF7
GO

Sequence cautioni

The sequence AAD18248.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA98305.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18248.1. Different initiation.
AE002161 Genomic DNA. Translation: AAF73695.1.
BA000008 Genomic DNA. Translation: BAA98305.1. Different initiation.
AE009440 Genomic DNA. Translation: AAP98028.1.
PIRiC72120.
G86502.
RefSeqiNP_445221.1. NC_002179.2.
NP_876371.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18248; AAD18248; CPn_0095.
AAF73695; AAF73695; CP_0679.
AAP98028; AAP98028; CpB0095.
BAA98305; BAA98305; BAA98305.
KEGGicpa:CP0679.
cpj:CPj0095.
cpt:CpB0095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18248.1. Different initiation.
AE002161 Genomic DNA. Translation: AAF73695.1.
BA000008 Genomic DNA. Translation: BAA98305.1. Different initiation.
AE009440 Genomic DNA. Translation: AAP98028.1.
PIRiC72120.
G86502.
RefSeqiNP_445221.1. NC_002179.2.
NP_876371.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9Z986.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18248; AAD18248; CPn_0095.
AAF73695; AAF73695; CP_0679.
AAP98028; AAP98028; CpB0095.
BAA98305; BAA98305; BAA98305.
KEGGicpa:CP0679.
cpj:CPj0095.
cpt:CpB0095.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000034686.
KOiK08884.
OMAiSIFHKIC.
OrthoDBiEOG6W45P7.

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-701-MONOMER.
CPNE115713:GHEY-98-MONOMER.
CPNE138677:GH8N-98-MONOMER.
CPNE182082:GH4N-98-MONOMER.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiPKND_CHLPN
AccessioniPrimary (citable) accession number: Q9Z986
Secondary accession number(s): Q9K216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: June 24, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.