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Q9Z984 (KPYK_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase
Short name=PK
EC=2.7.1.40
Gene names
Name:pyk
Ordered Locus Names:CPn_0097, CP_0677, CpB0097
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Pyruvate kinase
PRO_0000112062

Sites

Metal binding351Potassium By similarity
Metal binding371Potassium By similarity
Metal binding671Potassium By similarity
Metal binding681Potassium; via carbonyl oxygen By similarity
Metal binding2211Magnesium By similarity
Metal binding2451Magnesium By similarity
Binding site331Substrate By similarity
Binding site2441Substrate; via amide nitrogen By similarity
Binding site2451Substrate; via amide nitrogen By similarity
Binding site2771Substrate By similarity
Site2191Transition state stabilizer By similarity

Experimental info

Sequence conflict1881V → N in BAA98307. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9Z984 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 101E49E4F7CDD7B2

FASTA48452,666
        10         20         30         40         50         60 
MITRTKIICT IGPATNSPEM LAKLLDAGMN VARLNFSHGS HETHGQAIGF LKELREQKRV 

        70         80         90        100        110        120 
PLAIMLDTKG PEIRLGNIPQ PISVSQGQKL RLVSSDIDGS AEGGVSLYPK GIFPFVPEGA 

       130        140        150        160        170        180 
DVLIDDGYIH AVVVSSEADS LELEFMNSGL LKSHKSLSIR GVDVALPFMT EKDIADLKFG 

       190        200        210        220        230        240 
VEQNMDVVAA SFVRYGEDIE TMRKCLADLG NPKMPIIAKI ENRLGVENFS KIAKLADGIM 

       250        260        270        280        290        300 
IARGDLGIEL SVVEVPNLQK MMAKVSRETG HFCVTATQML ESMIRNVLPT RAEVSDIANA 

       310        320        330        340        350        360 
IYDGSSAVML SGETASGAHP VAAVKIMRSV ILETEKNLSH DSFLKLDDSN SALQVSPYLS 

       370        380        390        400        410        420 
AIGLAGIQIA ERADAKALIV YTESGSSPMF LSKYRPKFPI IAVTPSTSVY YRLALEWGVY 

       430        440        450        460        470        480 
PMLTQESDRA VWRHQACIYG IEQGILSNYD RILVLSRGAC MEETNNLTLT IVNDILTGSE 


FPET

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001363 Genomic DNA. Translation: AAD18250.1.
AE002161 Genomic DNA. Translation: AAF38488.1.
BA000008 Genomic DNA. Translation: BAA98307.1.
AE009440 Genomic DNA. Translation: AAP98030.1.
PIRA72119.
A86503.
RefSeqNP_224305.1. NC_000922.1.
NP_300156.1. NC_002491.1.
NP_445219.1. NC_002179.2.
NP_876373.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z984.
ModBaseSearch...

Protein-protein interaction databases

STRING115713.CPn0097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD18250; AAD18250; CPn_0097.
AAF38488; AAF38488; CP_0677.
AAP98030; AAP98030; CpB0097.
BAA98307; BAA98307; BAA98307.
GeneID1466780.
895703.
918888.
963225.
KEGGcpa:CP0677.
cpj:CPj0097.
cpn:CPn0097.
cpt:CpB0097.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021559.
KOK00873.
OMAIVYTESG.
ProtClustDBPRK05826.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-675-MONOMER.
CPNE115713:GHEY-100-MONOMER.
CPNE138677:GH8N-94-MONOMER.
CPNE182082:GH4N-98-MONOMER.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. PK_B_barrel_like. 1 hit.
SSF52935. Pyruvate_kinase. 1 hit.
SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_CHLPN
AccessionPrimary (citable) accession number: Q9Z984
Secondary accession number(s): Q9JSJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents