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Q9Z984

- KPYK_CHLPN

UniProt

Q9Z984 - KPYK_CHLPN

Protein

Pyruvate kinase

Gene

pyk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331SubstrateBy similarity
    Metal bindingi35 – 351PotassiumBy similarity
    Metal bindingi37 – 371PotassiumBy similarity
    Metal bindingi67 – 671PotassiumBy similarity
    Metal bindingi68 – 681Potassium; via carbonyl oxygenBy similarity
    Sitei219 – 2191Transition state stabilizerBy similarity
    Metal bindingi221 – 2211MagnesiumBy similarity
    Binding sitei244 – 2441Substrate; via amide nitrogenBy similarity
    Metal bindingi245 – 2451MagnesiumBy similarity
    Binding sitei245 – 2451Substrate; via amide nitrogenBy similarity
    Binding sitei277 – 2771SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-699-MONOMER.
    CPNE115713:GHEY-100-MONOMER.
    CPNE138677:GH8N-100-MONOMER.
    CPNE182082:GH4N-100-MONOMER.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    Ordered Locus Names:CPn_0097, CP_0677, CpB0097
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Pyruvate kinasePRO_0000112062Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi115713.CPn0097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z984.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    HOGENOMiHOG000021559.
    KOiK00873.
    OMAiTHEDHKE.
    OrthoDBiEOG6GBMB0.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z984-1 [UniParc]FASTAAdd to Basket

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    MITRTKIICT IGPATNSPEM LAKLLDAGMN VARLNFSHGS HETHGQAIGF    50
    LKELREQKRV PLAIMLDTKG PEIRLGNIPQ PISVSQGQKL RLVSSDIDGS 100
    AEGGVSLYPK GIFPFVPEGA DVLIDDGYIH AVVVSSEADS LELEFMNSGL 150
    LKSHKSLSIR GVDVALPFMT EKDIADLKFG VEQNMDVVAA SFVRYGEDIE 200
    TMRKCLADLG NPKMPIIAKI ENRLGVENFS KIAKLADGIM IARGDLGIEL 250
    SVVEVPNLQK MMAKVSRETG HFCVTATQML ESMIRNVLPT RAEVSDIANA 300
    IYDGSSAVML SGETASGAHP VAAVKIMRSV ILETEKNLSH DSFLKLDDSN 350
    SALQVSPYLS AIGLAGIQIA ERADAKALIV YTESGSSPMF LSKYRPKFPI 400
    IAVTPSTSVY YRLALEWGVY PMLTQESDRA VWRHQACIYG IEQGILSNYD 450
    RILVLSRGAC MEETNNLTLT IVNDILTGSE FPET 484
    Length:484
    Mass (Da):52,666
    Last modified:May 1, 1999 - v1
    Checksum:i101E49E4F7CDD7B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 1881V → N in BAA98307. (PubMed:10871362)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18250.1.
    AE002161 Genomic DNA. Translation: AAF38488.1.
    BA000008 Genomic DNA. Translation: BAA98307.1.
    AE009440 Genomic DNA. Translation: AAP98030.1.
    PIRiA72119.
    A86503.
    RefSeqiNP_224305.1. NC_000922.1.
    NP_300156.1. NC_002491.1.
    NP_445219.1. NC_002179.2.
    NP_876373.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18250; AAD18250; CPn_0097.
    AAF38488; AAF38488; CP_0677.
    AAP98030; AAP98030; CpB0097.
    BAA98307; BAA98307; BAA98307.
    GeneIDi1466780.
    895703.
    918888.
    963225.
    KEGGicpa:CP0677.
    cpj:CPj0097.
    cpn:CPn0097.
    cpt:CpB0097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18250.1 .
    AE002161 Genomic DNA. Translation: AAF38488.1 .
    BA000008 Genomic DNA. Translation: BAA98307.1 .
    AE009440 Genomic DNA. Translation: AAP98030.1 .
    PIRi A72119.
    A86503.
    RefSeqi NP_224305.1. NC_000922.1.
    NP_300156.1. NC_002491.1.
    NP_445219.1. NC_002179.2.
    NP_876373.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z984.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18250 ; AAD18250 ; CPn_0097 .
    AAF38488 ; AAF38488 ; CP_0677 .
    AAP98030 ; AAP98030 ; CpB0097 .
    BAA98307 ; BAA98307 ; BAA98307 .
    GeneIDi 1466780.
    895703.
    918888.
    963225.
    KEGGi cpa:CP0677.
    cpj:CPj0097.
    cpn:CPn0097.
    cpt:CpB0097.

    Phylogenomic databases

    eggNOGi COG0469.
    HOGENOMi HOG000021559.
    KOi K00873.
    OMAi THEDHKE.
    OrthoDBi EOG6GBMB0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BioCyci CPNE115711:GI7B-699-MONOMER.
    CPNE115713:GHEY-100-MONOMER.
    CPNE138677:GH8N-100-MONOMER.
    CPNE182082:GH4N-100-MONOMER.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiKPYK_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z984
    Secondary accession number(s): Q9JSJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3