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Q9Z984

- KPYK_CHLPN

UniProt

Q9Z984 - KPYK_CHLPN

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Protein

Pyruvate kinase

Gene
pyk, CPn_0097, CP_0677, CpB0097
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.
Potassium.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Substrate By similarity
Metal bindingi35 – 351Potassium By similarity
Metal bindingi37 – 371Potassium By similarity
Metal bindingi67 – 671Potassium By similarity
Metal bindingi68 – 681Potassium; via carbonyl oxygen By similarity
Sitei219 – 2191Transition state stabilizer By similarity
Metal bindingi221 – 2211Magnesium By similarity
Binding sitei244 – 2441Substrate; via amide nitrogen By similarity
Metal bindingi245 – 2451Magnesium By similarity
Binding sitei245 – 2451Substrate; via amide nitrogen By similarity
Binding sitei277 – 2771Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-699-MONOMER.
CPNE115713:GHEY-100-MONOMER.
CPNE138677:GH8N-100-MONOMER.
CPNE182082:GH4N-100-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:CPn_0097, CP_0677, CpB0097
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Pyruvate kinasePRO_0000112062Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi115713.CPn0097.

Structurei

3D structure databases

ProteinModelPortaliQ9Z984.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiTHEDHKE.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z984-1 [UniParc]FASTAAdd to Basket

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MITRTKIICT IGPATNSPEM LAKLLDAGMN VARLNFSHGS HETHGQAIGF    50
LKELREQKRV PLAIMLDTKG PEIRLGNIPQ PISVSQGQKL RLVSSDIDGS 100
AEGGVSLYPK GIFPFVPEGA DVLIDDGYIH AVVVSSEADS LELEFMNSGL 150
LKSHKSLSIR GVDVALPFMT EKDIADLKFG VEQNMDVVAA SFVRYGEDIE 200
TMRKCLADLG NPKMPIIAKI ENRLGVENFS KIAKLADGIM IARGDLGIEL 250
SVVEVPNLQK MMAKVSRETG HFCVTATQML ESMIRNVLPT RAEVSDIANA 300
IYDGSSAVML SGETASGAHP VAAVKIMRSV ILETEKNLSH DSFLKLDDSN 350
SALQVSPYLS AIGLAGIQIA ERADAKALIV YTESGSSPMF LSKYRPKFPI 400
IAVTPSTSVY YRLALEWGVY PMLTQESDRA VWRHQACIYG IEQGILSNYD 450
RILVLSRGAC MEETNNLTLT IVNDILTGSE FPET 484
Length:484
Mass (Da):52,666
Last modified:May 1, 1999 - v1
Checksum:i101E49E4F7CDD7B2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881V → N in BAA98307. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18250.1.
AE002161 Genomic DNA. Translation: AAF38488.1.
BA000008 Genomic DNA. Translation: BAA98307.1.
AE009440 Genomic DNA. Translation: AAP98030.1.
PIRiA72119.
A86503.
RefSeqiNP_224305.1. NC_000922.1.
NP_300156.1. NC_002491.1.
NP_445219.1. NC_002179.2.
NP_876373.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18250; AAD18250; CPn_0097.
AAF38488; AAF38488; CP_0677.
AAP98030; AAP98030; CpB0097.
BAA98307; BAA98307; BAA98307.
GeneIDi1466780.
895703.
918888.
963225.
KEGGicpa:CP0677.
cpj:CPj0097.
cpn:CPn0097.
cpt:CpB0097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18250.1 .
AE002161 Genomic DNA. Translation: AAF38488.1 .
BA000008 Genomic DNA. Translation: BAA98307.1 .
AE009440 Genomic DNA. Translation: AAP98030.1 .
PIRi A72119.
A86503.
RefSeqi NP_224305.1. NC_000922.1.
NP_300156.1. NC_002491.1.
NP_445219.1. NC_002179.2.
NP_876373.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z984.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18250 ; AAD18250 ; CPn_0097 .
AAF38488 ; AAF38488 ; CP_0677 .
AAP98030 ; AAP98030 ; CpB0097 .
BAA98307 ; BAA98307 ; BAA98307 .
GeneIDi 1466780.
895703.
918888.
963225.
KEGGi cpa:CP0677.
cpj:CPj0097.
cpn:CPn0097.
cpt:CpB0097.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi THEDHKE.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci CPNE115711:GI7B-699-MONOMER.
CPNE115713:GHEY-100-MONOMER.
CPNE138677:GH8N-100-MONOMER.
CPNE182082:GH4N-100-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiKPYK_CHLPN
AccessioniPrimary (citable) accession number: Q9Z984
Secondary accession number(s): Q9JSJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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