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Protein

Guanylate kinase

Gene

gmk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:CPn_0120, CP_0653, CpB0121
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705201 – 205Guanylate kinaseAdd BLAST205

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0121.

Structurei

3D structure databases

ProteinModelPortaliQ9Z961.
SMRiQ9Z961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 197Guanylate kinase-likeAdd BLAST179

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
HOGENOMiHOG000037638.
KOiK00942.
OrthoDBiPOG091H01Q4.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKILVDSPF SPDHQKCCPK LFTISAPAGV GKTTLVRMLE QEFSSAFAET
60 70 80 90 100
ISVTTRKPRE GEVPGKDYHF VSHEEFQRLL DRQALLEWVF LFGECYGTSM
110 120 130 140 150
LEIERIWSLG KHAVAVIDIQ GALFIRSRMP SVSIFIAPPS QEELERRLAS
160 170 180 190 200
RGSEEGSQRK ERLEHSLIEL AAANQFDYVI INDDLNQAYR VLKSIFIAEE

HRNIL
Length:205
Mass (Da):23,368
Last modified:May 1, 1999 - v1
Checksum:i84A5422A624555F5
GO

Sequence cautioni

The sequence AAP98054 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18273.1.
AE002161 Genomic DNA. Translation: AAF38468.1.
BA000008 Genomic DNA. Translation: BAA98331.1.
AE009440 Genomic DNA. Translation: AAP98054.1. Different initiation.
PIRiA86506.
F72117.
RefSeqiNP_224328.1. NC_000922.1.
WP_010882770.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18273; AAD18273; CPn_0120.
AAF38468; AAF38468; CP_0653.
AAP98054; AAP98054; CpB0121.
BAA98331; BAA98331; BAA98331.
GeneIDi895034.
KEGGicpa:CP_0653.
cpj:gmk.
cpn:CPn0120.
cpt:CpB0121.
PATRICifig|115713.3.peg.135.

Similar proteinsi

Entry informationi

Entry nameiKGUA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z961
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families