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Q9Z961

- KGUA_CHLPN

UniProt

Q9Z961 - KGUA_CHLPN

Protein

Guanylate kinase

Gene

gmk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Essential for recycling GMP and indirectly, cGMP.By similarity

    Catalytic activityi

    ATP + GMP = ADP + GDP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 338ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. guanylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-675-MONOMER.
    CPNE115713:GHEY-124-MONOMER.
    CPNE138677:GH8N-123-MONOMER.
    CPNE182082:GH4N-124-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinase (EC:2.7.4.8)
    Alternative name(s):
    GMP kinase
    Gene namesi
    Name:gmk
    Ordered Locus Names:CPn_0120, CP_0653, CpB0121
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Guanylate kinasePRO_0000170520Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0120.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z961.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 197179Guanylate kinase-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.Curated
    Contains 1 guanylate kinase-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0194.
    HOGENOMiHOG000037638.
    KOiK00942.
    OMAiNFLEWEE.
    OrthoDBiEOG6CP410.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00328. Guanylate_kinase.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z961-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKILVDSPF SPDHQKCCPK LFTISAPAGV GKTTLVRMLE QEFSSAFAET    50
    ISVTTRKPRE GEVPGKDYHF VSHEEFQRLL DRQALLEWVF LFGECYGTSM 100
    LEIERIWSLG KHAVAVIDIQ GALFIRSRMP SVSIFIAPPS QEELERRLAS 150
    RGSEEGSQRK ERLEHSLIEL AAANQFDYVI INDDLNQAYR VLKSIFIAEE 200
    HRNIL 205
    Length:205
    Mass (Da):23,368
    Last modified:May 1, 1999 - v1
    Checksum:i84A5422A624555F5
    GO

    Sequence cautioni

    The sequence AAP98054.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18273.1.
    AE002161 Genomic DNA. Translation: AAF38468.1.
    BA000008 Genomic DNA. Translation: BAA98331.1.
    AE009440 Genomic DNA. Translation: AAP98054.1. Different initiation.
    PIRiA86506.
    F72117.
    RefSeqiNP_224328.1. NC_000922.1.
    NP_300180.1. NC_002491.1.
    NP_445195.1. NC_002179.2.
    NP_876397.2. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18273; AAD18273; CPn_0120.
    AAF38468; AAF38468; CP_0653.
    AAP98054; AAP98054; CpB0121.
    BAA98331; BAA98331; BAA98331.
    GeneIDi1466804.
    895034.
    918908.
    963237.
    KEGGicpa:CP0653.
    cpj:CPj0120.
    cpn:CPn0120.
    cpt:CpB0121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18273.1 .
    AE002161 Genomic DNA. Translation: AAF38468.1 .
    BA000008 Genomic DNA. Translation: BAA98331.1 .
    AE009440 Genomic DNA. Translation: AAP98054.1 . Different initiation.
    PIRi A86506.
    F72117.
    RefSeqi NP_224328.1. NC_000922.1.
    NP_300180.1. NC_002491.1.
    NP_445195.1. NC_002179.2.
    NP_876397.2. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z961.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18273 ; AAD18273 ; CPn_0120 .
    AAF38468 ; AAF38468 ; CP_0653 .
    AAP98054 ; AAP98054 ; CpB0121 .
    BAA98331 ; BAA98331 ; BAA98331 .
    GeneIDi 1466804.
    895034.
    918908.
    963237.
    KEGGi cpa:CP0653.
    cpj:CPj0120.
    cpn:CPn0120.
    cpt:CpB0121.

    Phylogenomic databases

    eggNOGi COG0194.
    HOGENOMi HOG000037638.
    KOi K00942.
    OMAi NFLEWEE.
    OrthoDBi EOG6CP410.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-675-MONOMER.
    CPNE115713:GHEY-124-MONOMER.
    CPNE138677:GH8N-123-MONOMER.
    CPNE182082:GH4N-124-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00328. Guanylate_kinase.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiKGUA_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3