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Q9Z961

- KGUA_CHLPN

UniProt

Q9Z961 - KGUA_CHLPN

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Protein

Guanylate kinase

Gene

gmk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-675-MONOMER.
CPNE115713:GHEY-124-MONOMER.
CPNE138677:GH8N-123-MONOMER.
CPNE182082:GH4N-124-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:CPn_0120, CP_0653, CpB0121
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Guanylate kinasePRO_0000170520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0120.

Structurei

3D structure databases

ProteinModelPortaliQ9Z961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 197179Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated
Contains 1 guanylate kinase-like domain.Curated

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiNFLEWEE.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z961-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKILVDSPF SPDHQKCCPK LFTISAPAGV GKTTLVRMLE QEFSSAFAET
60 70 80 90 100
ISVTTRKPRE GEVPGKDYHF VSHEEFQRLL DRQALLEWVF LFGECYGTSM
110 120 130 140 150
LEIERIWSLG KHAVAVIDIQ GALFIRSRMP SVSIFIAPPS QEELERRLAS
160 170 180 190 200
RGSEEGSQRK ERLEHSLIEL AAANQFDYVI INDDLNQAYR VLKSIFIAEE

HRNIL
Length:205
Mass (Da):23,368
Last modified:May 1, 1999 - v1
Checksum:i84A5422A624555F5
GO

Sequence cautioni

The sequence AAP98054.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18273.1.
AE002161 Genomic DNA. Translation: AAF38468.1.
BA000008 Genomic DNA. Translation: BAA98331.1.
AE009440 Genomic DNA. Translation: AAP98054.1. Different initiation.
PIRiA86506.
F72117.
RefSeqiNP_224328.1. NC_000922.1.
NP_300180.1. NC_002491.1.
NP_445195.1. NC_002179.2.
NP_876397.2. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18273; AAD18273; CPn_0120.
AAF38468; AAF38468; CP_0653.
AAP98054; AAP98054; CpB0121.
BAA98331; BAA98331; BAA98331.
GeneIDi1466804.
895034.
918908.
963237.
KEGGicpa:CP0653.
cpj:CPj0120.
cpn:CPn0120.
cpt:CpB0121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18273.1 .
AE002161 Genomic DNA. Translation: AAF38468.1 .
BA000008 Genomic DNA. Translation: BAA98331.1 .
AE009440 Genomic DNA. Translation: AAP98054.1 . Different initiation.
PIRi A86506.
F72117.
RefSeqi NP_224328.1. NC_000922.1.
NP_300180.1. NC_002491.1.
NP_445195.1. NC_002179.2.
NP_876397.2. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z961.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18273 ; AAD18273 ; CPn_0120 .
AAF38468 ; AAF38468 ; CP_0653 .
AAP98054 ; AAP98054 ; CpB0121 .
BAA98331 ; BAA98331 ; BAA98331 .
GeneIDi 1466804.
895034.
918908.
963237.
KEGGi cpa:CP0653.
cpj:CPj0120.
cpn:CPn0120.
cpt:CpB0121.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037638.
KOi K00942.
OMAi NFLEWEE.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-675-MONOMER.
CPNE115713:GHEY-124-MONOMER.
CPNE138677:GH8N-123-MONOMER.
CPNE182082:GH4N-124-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiKGUA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3