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Q9Z930

- SYL_CHLPN

UniProt

Q9Z930 - SYL_CHLPN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei604 – 6041ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-639-MONOMER.
    CPNE115713:GHEY-158-MONOMER.
    CPNE138677:GH8N-156-MONOMER.
    CPNE182082:GH4N-158-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CPn_0153, CP_0618, CpB0154
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 820820Leucine--tRNA ligasePRO_0000151998Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0153.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z930.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi601 – 6055"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z930-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYDPNLIEK KWQQFWKEHR SFQANEDEDK VKYYVLDMFP YPSGAGLHVG    50
    HLIGYTATDI VARYKRARGF SVLHPMGWDS FGLPAEQYAI RTGTHPKVTT 100
    QKNIANFKKQ LSAMGFSYDE GREFATSDPD YYHWTQKLFL FLYDQGLAYM 150
    ADMAVNYCPE LGTVLSNEEV ENGFSIEGGY PVERKMLRQW ILKITAYADK 200
    LLEGLDALDW PENVKQLQKN WIGKSEGALV TFHLTQEGSL EAFTTRLDTL 250
    LGVSFLVIAP EHPDLDSIVS EEQRDEVTAY VQESLRKSER DRISSVKTKT 300
    GVFTGNYAKH PITGNLLPVW ISDYVVLGYG TGVVMGVPAH DERDREFAEM 350
    FSLPIHEVID DNGVCIHSNY NDFCLNGLSG QEAKDYVINY LEMRSLGRAK 400
    TMYRLRDWLF SRQRYWGEPI PIIHFEDGTH RPLEDDELPL LPPNIDDYRP 450
    EGFGQGPLAK AQDWVHIYDE KTGRPGCRET YTMPQWAGSC WYYLRFCDAH 500
    NSQLPWSKEK ESYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYDAGLVSTP 550
    EPFKKLINQG LVLASSYRIP GKGYVSIEDV REENGTWIST CGEIVEVRQE 600
    KMSKSKLNGV DPQVLIEEYG ADALRMYAMF SGPLDKNKTW SNEGVGGCRR 650
    FLNRFYDLVT SSEVQDIEDR DGLVLAHKLV FRITEHIEKM SLNTIPSSFM 700
    EFLNDFSKLP VYSKRALSMA VRVLEPIAPH ISEELWVILG NPPGIDQAAW 750
    PQIDESYLVA QTVTFVVQVN GKLRGRLEVA KEAPKEEVLS LSRSVVAKYL 800
    ENAQIRKEIY VPNKLVNFVL 820
    Length:820
    Mass (Da):93,966
    Last modified:May 1, 1999 - v1
    Checksum:i520369FC098F1926
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18306.1.
    AE002161 Genomic DNA. Translation: AAF38433.1.
    BA000008 Genomic DNA. Translation: BAA98363.1.
    AE009440 Genomic DNA. Translation: AAP98087.1.
    PIRiA86510.
    C72113.
    RefSeqiNP_224361.1. NC_000922.1.
    NP_300212.1. NC_002491.1.
    NP_445160.1. NC_002179.2.
    NP_876430.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18306; AAD18306; CPn_0153.
    AAF38433; AAF38433; CP_0618.
    AAP98087; AAP98087; CpB0154.
    BAA98363; BAA98363; BAA98363.
    GeneIDi1466837.
    894824.
    918944.
    963282.
    KEGGicpa:CP0618.
    cpj:CPj0153.
    cpn:CPn0153.
    cpt:CpB0154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18306.1 .
    AE002161 Genomic DNA. Translation: AAF38433.1 .
    BA000008 Genomic DNA. Translation: BAA98363.1 .
    AE009440 Genomic DNA. Translation: AAP98087.1 .
    PIRi A86510.
    C72113.
    RefSeqi NP_224361.1. NC_000922.1.
    NP_300212.1. NC_002491.1.
    NP_445160.1. NC_002179.2.
    NP_876430.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z930.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18306 ; AAD18306 ; CPn_0153 .
    AAF38433 ; AAF38433 ; CP_0618 .
    AAP98087 ; AAP98087 ; CpB0154 .
    BAA98363 ; BAA98363 ; BAA98363 .
    GeneIDi 1466837.
    894824.
    918944.
    963282.
    KEGGi cpa:CP0618.
    cpj:CPj0153.
    cpn:CPn0153.
    cpt:CpB0154.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-639-MONOMER.
    CPNE115713:GHEY-158-MONOMER.
    CPNE138677:GH8N-156-MONOMER.
    CPNE182082:GH4N-158-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiSYL_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z930
    Secondary accession number(s): Q9JQ86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3