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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei604ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CPn_0153, CP_0618, CpB0154
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519981 – 820Leucine--tRNA ligaseAdd BLAST820

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0154

Structurei

3D structure databases

ProteinModelPortaliQ9Z930
SMRiQ9Z930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi601 – 605"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDPNLIEK KWQQFWKEHR SFQANEDEDK VKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRARGF SVLHPMGWDS FGLPAEQYAI RTGTHPKVTT
110 120 130 140 150
QKNIANFKKQ LSAMGFSYDE GREFATSDPD YYHWTQKLFL FLYDQGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEV ENGFSIEGGY PVERKMLRQW ILKITAYADK
210 220 230 240 250
LLEGLDALDW PENVKQLQKN WIGKSEGALV TFHLTQEGSL EAFTTRLDTL
260 270 280 290 300
LGVSFLVIAP EHPDLDSIVS EEQRDEVTAY VQESLRKSER DRISSVKTKT
310 320 330 340 350
GVFTGNYAKH PITGNLLPVW ISDYVVLGYG TGVVMGVPAH DERDREFAEM
360 370 380 390 400
FSLPIHEVID DNGVCIHSNY NDFCLNGLSG QEAKDYVINY LEMRSLGRAK
410 420 430 440 450
TMYRLRDWLF SRQRYWGEPI PIIHFEDGTH RPLEDDELPL LPPNIDDYRP
460 470 480 490 500
EGFGQGPLAK AQDWVHIYDE KTGRPGCRET YTMPQWAGSC WYYLRFCDAH
510 520 530 540 550
NSQLPWSKEK ESYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYDAGLVSTP
560 570 580 590 600
EPFKKLINQG LVLASSYRIP GKGYVSIEDV REENGTWIST CGEIVEVRQE
610 620 630 640 650
KMSKSKLNGV DPQVLIEEYG ADALRMYAMF SGPLDKNKTW SNEGVGGCRR
660 670 680 690 700
FLNRFYDLVT SSEVQDIEDR DGLVLAHKLV FRITEHIEKM SLNTIPSSFM
710 720 730 740 750
EFLNDFSKLP VYSKRALSMA VRVLEPIAPH ISEELWVILG NPPGIDQAAW
760 770 780 790 800
PQIDESYLVA QTVTFVVQVN GKLRGRLEVA KEAPKEEVLS LSRSVVAKYL
810 820
ENAQIRKEIY VPNKLVNFVL
Length:820
Mass (Da):93,966
Last modified:May 1, 1999 - v1
Checksum:i520369FC098F1926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18306.1
AE002161 Genomic DNA Translation: AAF38433.1
BA000008 Genomic DNA Translation: BAA98363.1
AE009440 Genomic DNA Translation: AAP98087.1
PIRiA86510
C72113
RefSeqiNP_224361.1, NC_000922.1
WP_010882803.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18306; AAD18306; CPn_0153
AAF38433; AAF38433; CP_0618
AAP98087; AAP98087; CpB0154
BAA98363; BAA98363; BAA98363
GeneIDi894824
KEGGicpa:CP_0618
cpj:leuS
cpn:CPn0153
cpt:CpB0154
PATRICifig|115713.3.peg.175

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLPN
AccessioniPrimary (citable) accession number: Q9Z930
Secondary accession number(s): Q9JQ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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