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Q9Z930

- SYL_CHLPN

UniProt

Q9Z930 - SYL_CHLPN

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Protein
Leucine--tRNA ligase
Gene
leuS, CPn_0153, CP_0618, CpB0154
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei604 – 6041ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-639-MONOMER.
CPNE115713:GHEY-158-MONOMER.
CPNE138677:GH8N-156-MONOMER.
CPNE182082:GH4N-158-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CPn_0153, CP_0618, CpB0154
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligaseUniRule annotation
PRO_0000151998Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0153.

Structurei

3D structure databases

ProteinModelPortaliQ9Z930.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi601 – 6055"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z930-1 [UniParc]FASTAAdd to Basket

« Hide

MRYDPNLIEK KWQQFWKEHR SFQANEDEDK VKYYVLDMFP YPSGAGLHVG    50
HLIGYTATDI VARYKRARGF SVLHPMGWDS FGLPAEQYAI RTGTHPKVTT 100
QKNIANFKKQ LSAMGFSYDE GREFATSDPD YYHWTQKLFL FLYDQGLAYM 150
ADMAVNYCPE LGTVLSNEEV ENGFSIEGGY PVERKMLRQW ILKITAYADK 200
LLEGLDALDW PENVKQLQKN WIGKSEGALV TFHLTQEGSL EAFTTRLDTL 250
LGVSFLVIAP EHPDLDSIVS EEQRDEVTAY VQESLRKSER DRISSVKTKT 300
GVFTGNYAKH PITGNLLPVW ISDYVVLGYG TGVVMGVPAH DERDREFAEM 350
FSLPIHEVID DNGVCIHSNY NDFCLNGLSG QEAKDYVINY LEMRSLGRAK 400
TMYRLRDWLF SRQRYWGEPI PIIHFEDGTH RPLEDDELPL LPPNIDDYRP 450
EGFGQGPLAK AQDWVHIYDE KTGRPGCRET YTMPQWAGSC WYYLRFCDAH 500
NSQLPWSKEK ESYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYDAGLVSTP 550
EPFKKLINQG LVLASSYRIP GKGYVSIEDV REENGTWIST CGEIVEVRQE 600
KMSKSKLNGV DPQVLIEEYG ADALRMYAMF SGPLDKNKTW SNEGVGGCRR 650
FLNRFYDLVT SSEVQDIEDR DGLVLAHKLV FRITEHIEKM SLNTIPSSFM 700
EFLNDFSKLP VYSKRALSMA VRVLEPIAPH ISEELWVILG NPPGIDQAAW 750
PQIDESYLVA QTVTFVVQVN GKLRGRLEVA KEAPKEEVLS LSRSVVAKYL 800
ENAQIRKEIY VPNKLVNFVL 820
Length:820
Mass (Da):93,966
Last modified:May 1, 1999 - v1
Checksum:i520369FC098F1926
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18306.1.
AE002161 Genomic DNA. Translation: AAF38433.1.
BA000008 Genomic DNA. Translation: BAA98363.1.
AE009440 Genomic DNA. Translation: AAP98087.1.
PIRiA86510.
C72113.
RefSeqiNP_224361.1. NC_000922.1.
NP_300212.1. NC_002491.1.
NP_445160.1. NC_002179.2.
NP_876430.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18306; AAD18306; CPn_0153.
AAF38433; AAF38433; CP_0618.
AAP98087; AAP98087; CpB0154.
BAA98363; BAA98363; BAA98363.
GeneIDi1466837.
894824.
918944.
963282.
KEGGicpa:CP0618.
cpj:CPj0153.
cpn:CPn0153.
cpt:CpB0154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18306.1 .
AE002161 Genomic DNA. Translation: AAF38433.1 .
BA000008 Genomic DNA. Translation: BAA98363.1 .
AE009440 Genomic DNA. Translation: AAP98087.1 .
PIRi A86510.
C72113.
RefSeqi NP_224361.1. NC_000922.1.
NP_300212.1. NC_002491.1.
NP_445160.1. NC_002179.2.
NP_876430.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z930.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18306 ; AAD18306 ; CPn_0153 .
AAF38433 ; AAF38433 ; CP_0618 .
AAP98087 ; AAP98087 ; CpB0154 .
BAA98363 ; BAA98363 ; BAA98363 .
GeneIDi 1466837.
894824.
918944.
963282.
KEGGi cpa:CP0618.
cpj:CPj0153.
cpn:CPn0153.
cpt:CpB0154.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-639-MONOMER.
CPNE115713:GHEY-158-MONOMER.
CPNE138677:GH8N-156-MONOMER.
CPNE182082:GH4N-158-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiSYL_CHLPN
AccessioniPrimary (citable) accession number: Q9Z930
Secondary accession number(s): Q9JQ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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