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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61NADPUniRule annotation1
Binding sitei171NADPUniRule annotation1
Binding sitei201SubstrateUniRule annotation1
Binding sitei205SubstrateUniRule annotation1
Binding sitei239SubstrateUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Active sitei263Proton acceptorUniRule annotation1
Binding sitei360SubstrateUniRule annotation1
Binding sitei365SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 104NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:CPn_0238, CP_0524, CPj0238, CpB0244
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681161 – 512Glucose-6-phosphate 1-dehydrogenaseAdd BLAST512

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0244

Structurei

3D structure databases

ProteinModelPortaliQ9Z8U6
SMRiQ9Z8U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W Bacteria
COG0364 LUCA
HOGENOMiHOG000046191
KOiK00036
OMAiVEICVYE
OrthoDBiPOG091H04ZM

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z8U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVVQETIG GLNSPRTCPP CILVIFGATG DLTARKLLPA LYHLTKEGRL
60 70 80 90 100
SDQFVCVGFA RREKSNELFR QEMKQAVIQF SPSELDIKVW EDFQQRLFYH
110 120 130 140 150
RSEFDNNMGY TSLKDSLEDL DKTYGTRGNR LFYLSTPPQY FSRIIENLNK
160 170 180 190 200
HKLFYKNQDQ GKPWSRVIIE KPFGRDLDSA KQLQQCINEN LNENSVYHID
210 220 230 240 250
HYLGKETVQN ILTTRFANTI FESCWNSQYI DHVQISLSET IGIGSRGNFF
260 270 280 290 300
EKSGMLRDMV QNHMMQLLCL LTMEPPTTFD ADEIRKEKIK ILQRISPFSE
310 320 330 340 350
GSSIVRGQYG PGTVQGVSVL GYREEENVDK DSRVETYVAL KTVINNPRWL
360 370 380 390 400
GVPFYLRAGK RLAKKSTDIS IIFKKSPYNL FAAEECSRCP IENDLLIIRI
410 420 430 440 450
QPDEGVALKF NCKVPGTNNI VRPVKMDFRY DSYFQTTTPE AYERLLCDCI
460 470 480 490 500
IGDRTLFTGG DEVMASWKLF TPVLEEWDQD SSPSFPNYPA GSSGPKEADA
510
LIERDGRSWR PL
Length:512
Mass (Da):58,740
Last modified:May 1, 1999 - v1
Checksum:iEABC8DBFBC940BCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18391.1
AE002161 Genomic DNA Translation: AAF73682.1
BA000008 Genomic DNA Translation: BAA98448.1
AE009440 Genomic DNA Translation: AAP98177.1
PIRiC72103
F86520
RefSeqiNP_224447.1, NC_000922.1
WP_010882890.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18391; AAD18391; CPn_0238
AAF73682; AAF73682; CP_0524
AAP98177; AAP98177; CpB0244
BAA98448; BAA98448; BAA98448
GeneIDi895162
KEGGicpa:CP_0524
cpj:zwf
cpn:CPn0238
cpt:CpB0244
PATRICifig|115713.3.peg.268

Similar proteinsi

Entry informationi

Entry nameiG6PD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8U6
Secondary accession number(s): Q9JQ22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health