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Q9Z8U6

- G6PD_CHLPN

UniProt

Q9Z8U6 - G6PD_CHLPN

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611NADPUniRule annotation
    Binding sitei171 – 1711NADPUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei205 – 2051SubstrateUniRule annotation
    Binding sitei239 – 2391SubstrateUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Active sitei263 – 2631Proton acceptorUniRule annotation
    Binding sitei360 – 3601SubstrateUniRule annotation
    Binding sitei365 – 3651SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi103 – 1042NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-542-MONOMER.
    CPNE115713:GHEY-248-MONOMER.
    CPNE138677:GH8N-245-MONOMER.
    CPNE182082:GH4N-252-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:CPn_0238, CP_0524, CPj0238, CpB0244
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Glucose-6-phosphate 1-dehydrogenasePRO_0000068116Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0238.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z8U6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiHAFTESS.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z8U6-1 [UniParc]FASTAAdd to Basket

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    MTNVVQETIG GLNSPRTCPP CILVIFGATG DLTARKLLPA LYHLTKEGRL    50
    SDQFVCVGFA RREKSNELFR QEMKQAVIQF SPSELDIKVW EDFQQRLFYH 100
    RSEFDNNMGY TSLKDSLEDL DKTYGTRGNR LFYLSTPPQY FSRIIENLNK 150
    HKLFYKNQDQ GKPWSRVIIE KPFGRDLDSA KQLQQCINEN LNENSVYHID 200
    HYLGKETVQN ILTTRFANTI FESCWNSQYI DHVQISLSET IGIGSRGNFF 250
    EKSGMLRDMV QNHMMQLLCL LTMEPPTTFD ADEIRKEKIK ILQRISPFSE 300
    GSSIVRGQYG PGTVQGVSVL GYREEENVDK DSRVETYVAL KTVINNPRWL 350
    GVPFYLRAGK RLAKKSTDIS IIFKKSPYNL FAAEECSRCP IENDLLIIRI 400
    QPDEGVALKF NCKVPGTNNI VRPVKMDFRY DSYFQTTTPE AYERLLCDCI 450
    IGDRTLFTGG DEVMASWKLF TPVLEEWDQD SSPSFPNYPA GSSGPKEADA 500
    LIERDGRSWR PL 512
    Length:512
    Mass (Da):58,740
    Last modified:May 1, 1999 - v1
    Checksum:iEABC8DBFBC940BCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18391.1.
    AE002161 Genomic DNA. Translation: AAF73682.1.
    BA000008 Genomic DNA. Translation: BAA98448.1.
    AE009440 Genomic DNA. Translation: AAP98177.1.
    PIRiC72103.
    F86520.
    RefSeqiNP_224447.1. NC_000922.1.
    NP_300297.1. NC_002491.1.
    NP_445068.1. NC_002179.2.
    NP_876520.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18391; AAD18391; CPn_0238.
    AAF73682; AAF73682; CP_0524.
    AAP98177; AAP98177; CpB0244.
    BAA98448; BAA98448; BAA98448.
    GeneIDi1466927.
    895162.
    918927.
    962733.
    KEGGicpa:CP0524.
    cpj:CPj0238.
    cpn:CPn0238.
    cpt:CpB0244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18391.1 .
    AE002161 Genomic DNA. Translation: AAF73682.1 .
    BA000008 Genomic DNA. Translation: BAA98448.1 .
    AE009440 Genomic DNA. Translation: AAP98177.1 .
    PIRi C72103.
    F86520.
    RefSeqi NP_224447.1. NC_000922.1.
    NP_300297.1. NC_002491.1.
    NP_445068.1. NC_002179.2.
    NP_876520.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z8U6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0238.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18391 ; AAD18391 ; CPn_0238 .
    AAF73682 ; AAF73682 ; CP_0524 .
    AAP98177 ; AAP98177 ; CpB0244 .
    BAA98448 ; BAA98448 ; BAA98448 .
    GeneIDi 1466927.
    895162.
    918927.
    962733.
    KEGGi cpa:CP0524.
    cpj:CPj0238.
    cpn:CPn0238.
    cpt:CpB0244.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi HAFTESS.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci CPNE115711:GI7B-542-MONOMER.
    CPNE115713:GHEY-248-MONOMER.
    CPNE138677:GH8N-245-MONOMER.
    CPNE182082:GH4N-252-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiG6PD_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z8U6
    Secondary accession number(s): Q9JQ22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3