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Q9Z8U6 (G6PD_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:CPn_0238, CP_0524, CPj0238, CpB0244
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Glucose-6-phosphate 1-dehydrogenase
PRO_0000068116

Sites

Active site2631Proton acceptor By similarity
Binding site291NADP By similarity
Binding site611NADP By similarity
Binding site2011Substrate By similarity
Binding site2051Substrate By similarity
Binding site3651Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z8U6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: EABC8DBFBC940BCE

FASTA51258,740
        10         20         30         40         50         60 
MTNVVQETIG GLNSPRTCPP CILVIFGATG DLTARKLLPA LYHLTKEGRL SDQFVCVGFA 

        70         80         90        100        110        120 
RREKSNELFR QEMKQAVIQF SPSELDIKVW EDFQQRLFYH RSEFDNNMGY TSLKDSLEDL 

       130        140        150        160        170        180 
DKTYGTRGNR LFYLSTPPQY FSRIIENLNK HKLFYKNQDQ GKPWSRVIIE KPFGRDLDSA 

       190        200        210        220        230        240 
KQLQQCINEN LNENSVYHID HYLGKETVQN ILTTRFANTI FESCWNSQYI DHVQISLSET 

       250        260        270        280        290        300 
IGIGSRGNFF EKSGMLRDMV QNHMMQLLCL LTMEPPTTFD ADEIRKEKIK ILQRISPFSE 

       310        320        330        340        350        360 
GSSIVRGQYG PGTVQGVSVL GYREEENVDK DSRVETYVAL KTVINNPRWL GVPFYLRAGK 

       370        380        390        400        410        420 
RLAKKSTDIS IIFKKSPYNL FAAEECSRCP IENDLLIIRI QPDEGVALKF NCKVPGTNNI 

       430        440        450        460        470        480 
VRPVKMDFRY DSYFQTTTPE AYERLLCDCI IGDRTLFTGG DEVMASWKLF TPVLEEWDQD 

       490        500        510 
SSPSFPNYPA GSSGPKEADA LIERDGRSWR PL

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001363 Genomic DNA. Translation: AAD18391.1.
AE002161 Genomic DNA. Translation: AAF73682.1.
BA000008 Genomic DNA. Translation: BAA98448.1.
AE009440 Genomic DNA. Translation: AAP98177.1.
PIRC72103.
F86520.
RefSeqNP_224447.1. NC_000922.1.
NP_300297.1. NC_002491.1.
NP_445068.1. NC_002179.2.
NP_876520.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z8U6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1466927.
895162.
918927.
962733.
GenomeReviewsGene locus CPn_0238 in contig AE001363_GR.
Gene locus CP_0524 in contig AE002161_GR.
Gene locus CpB0244 in contig AE009440_GR.
Gene locus CPj0238 in contig BA000008_GR.
KEGGcpa:CP0524.
cpj:CPj0238.
cpn:CPn0238.
cpt:CpB0244.
TIGRCP_0524.

Phylogenomic databases

HOGENOMHBG322449.
OMATRWDEVE.
ProtClustDBPRK05722.

Enzyme and pathway databases

BioCycCPNE115711:CP_0524-MONOMER.
CPNE115713:CPN0238-MONOMER.
CPNE138677:CPJ0238-MONOMER.
CPNE182082:CPB0244-MONOMER.

Family and domain databases

InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00036.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. Zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_CHLPN
AccessionPrimary (citable) accession number: Q9Z8U6
Secondary accession number(s): Q9JQ22
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents