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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611NADPUniRule annotation
Binding sitei171 – 1711NADPUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Binding sitei239 – 2391SubstrateUniRule annotation
Binding sitei258 – 2581SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptorUniRule annotation
Binding sitei360 – 3601SubstrateUniRule annotation
Binding sitei365 – 3651SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1042NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-542-MONOMER.
CPNE115713:GHEY-248-MONOMER.
CPNE138677:GH8N-245-MONOMER.
CPNE182082:GH4N-252-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:CPn_0238, CP_0524, CPj0238, CpB0244
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Glucose-6-phosphate 1-dehydrogenasePRO_0000068116Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0238.

Structurei

3D structure databases

ProteinModelPortaliQ9Z8U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z8U6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNVVQETIG GLNSPRTCPP CILVIFGATG DLTARKLLPA LYHLTKEGRL
60 70 80 90 100
SDQFVCVGFA RREKSNELFR QEMKQAVIQF SPSELDIKVW EDFQQRLFYH
110 120 130 140 150
RSEFDNNMGY TSLKDSLEDL DKTYGTRGNR LFYLSTPPQY FSRIIENLNK
160 170 180 190 200
HKLFYKNQDQ GKPWSRVIIE KPFGRDLDSA KQLQQCINEN LNENSVYHID
210 220 230 240 250
HYLGKETVQN ILTTRFANTI FESCWNSQYI DHVQISLSET IGIGSRGNFF
260 270 280 290 300
EKSGMLRDMV QNHMMQLLCL LTMEPPTTFD ADEIRKEKIK ILQRISPFSE
310 320 330 340 350
GSSIVRGQYG PGTVQGVSVL GYREEENVDK DSRVETYVAL KTVINNPRWL
360 370 380 390 400
GVPFYLRAGK RLAKKSTDIS IIFKKSPYNL FAAEECSRCP IENDLLIIRI
410 420 430 440 450
QPDEGVALKF NCKVPGTNNI VRPVKMDFRY DSYFQTTTPE AYERLLCDCI
460 470 480 490 500
IGDRTLFTGG DEVMASWKLF TPVLEEWDQD SSPSFPNYPA GSSGPKEADA
510
LIERDGRSWR PL
Length:512
Mass (Da):58,740
Last modified:May 1, 1999 - v1
Checksum:iEABC8DBFBC940BCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18391.1.
AE002161 Genomic DNA. Translation: AAF73682.1.
BA000008 Genomic DNA. Translation: BAA98448.1.
AE009440 Genomic DNA. Translation: AAP98177.1.
PIRiC72103.
F86520.
RefSeqiNP_224447.1. NC_000922.1.
NP_300297.1. NC_002491.1.
NP_445068.1. NC_002179.2.
NP_876520.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18391; AAD18391; CPn_0238.
AAF73682; AAF73682; CP_0524.
AAP98177; AAP98177; CpB0244.
BAA98448; BAA98448; BAA98448.
GeneIDi1466927.
895162.
918927.
962733.
KEGGicpa:CP0524.
cpj:CPj0238.
cpn:CPn0238.
cpt:CpB0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18391.1.
AE002161 Genomic DNA. Translation: AAF73682.1.
BA000008 Genomic DNA. Translation: BAA98448.1.
AE009440 Genomic DNA. Translation: AAP98177.1.
PIRiC72103.
F86520.
RefSeqiNP_224447.1. NC_000922.1.
NP_300297.1. NC_002491.1.
NP_445068.1. NC_002179.2.
NP_876520.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9Z8U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18391; AAD18391; CPn_0238.
AAF73682; AAF73682; CP_0524.
AAP98177; AAP98177; CpB0244.
BAA98448; BAA98448; BAA98448.
GeneIDi1466927.
895162.
918927.
962733.
KEGGicpa:CP0524.
cpj:CPj0238.
cpn:CPn0238.
cpt:CpB0244.

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciCPNE115711:GI7B-542-MONOMER.
CPNE115713:GHEY-248-MONOMER.
CPNE138677:GH8N-245-MONOMER.
CPNE182082:GH4N-252-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiG6PD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8U6
Secondary accession number(s): Q9JQ22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.