Reviewed, UniProtKB/Swiss-Prot Q9Z8U6 (G6PD_CHLPN)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	CPn_0238, CP_0524, CPj0238, CpB0244

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068116
Sites
	Active site	263	1	Proton acceptor By similarity
	Binding site	29	1	NADP By similarity
	Binding site	61	1	NADP By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
	Binding site	365	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z8U6-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: EABC8DBFBC940BCE	FASTA	512	58,740
	10 20 30 40 50 60 MTNVVQETIG GLNSPRTCPP CILVIFGATG DLTARKLLPA LYHLTKEGRL SDQFVCVGFA 70 80 90 100 110 120 RREKSNELFR QEMKQAVIQF SPSELDIKVW EDFQQRLFYH RSEFDNNMGY TSLKDSLEDL 130 140 150 160 170 180 DKTYGTRGNR LFYLSTPPQY FSRIIENLNK HKLFYKNQDQ GKPWSRVIIE KPFGRDLDSA 190 200 210 220 230 240 KQLQQCINEN LNENSVYHID HYLGKETVQN ILTTRFANTI FESCWNSQYI DHVQISLSET 250 260 270 280 290 300 IGIGSRGNFF EKSGMLRDMV QNHMMQLLCL LTMEPPTTFD ADEIRKEKIK ILQRISPFSE 310 320 330 340 350 360 GSSIVRGQYG PGTVQGVSVL GYREEENVDK DSRVETYVAL KTVINNPRWL GVPFYLRAGK 370 380 390 400 410 420 RLAKKSTDIS IIFKKSPYNL FAAEECSRCP IENDLLIIRI QPDEGVALKF NCKVPGTNNI 430 440 450 460 470 480 VRPVKMDFRY DSYFQTTTPE AYERLLCDCI IGDRTLFTGG DEVMASWKLF TPVLEEWDQD 490 500 510 SSPSFPNYPA GSSGPKEADA LIERDGRSWR PL

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18391.1. AE002161 Genomic DNA. Translation: AAF73682.1. BA000008 Genomic DNA. Translation: BAA98448.1. AE009440 Genomic DNA. Translation: AAP98177.1.
PIR	C72103. F86520.
RefSeq	NP_224447.1. NP_300297.1. NP_445068.1. NP_876520.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1466927. 895162. 918927. 962733.
GenomeReviews	Gene locus CPn_0238 in contig AE001363_GR. Gene locus CP_0524 in contig AE002161_GR. Gene locus CpB0244 in contig AE009440_GR. Gene locus CPj0238 in contig BA000008_GR.
KEGG	cpa:CP0524. cpj:CPj0238. cpn:CPn0238. cpt:CpB0244.
TIGR	CP_0524.
Phylogenomic databases
HOGENOM	HBG322449.
OMA	QRADNIE.
PhylomeDB	Q9Z8U6.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0524-MONOMER. CPNE115713:CPN0238-MONOMER. CPNE138677:CPJ0238-MONOMER. CPNE182082:CPB0244-MONOMER.
BRENDA	1.1.1.49. 264832.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_CHLPN

Accession

Primary (citable) accession number: Q9Z8U6
Secondary accession number(s): Q9JQ22

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)