Reviewed,
UniProtKB/Swiss-Prot Q9Z8U6 (G6PD_CHLPN)
Last modified
February 9, 2010.
Version 67.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glucose-6-phosphate 1-dehydrogenase Short name=G6PD EC=1.1.1.49 | ||||
| Gene names |
| ||||
| Organism | Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83558 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila |
Protein attributes
| Sequence length | 512 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the glucose-6-phosphate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 512 | 512 | Glucose-6-phosphate 1-dehydrogenase | PRO_0000068116 | |||||
Sites | |||||||||
| Active site | 263 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 29 | 1 | NADP By similarity | ||||||
| Binding site | 61 | 1 | NADP By similarity | ||||||
| Binding site | 201 | 1 | Substrate By similarity | ||||||
| Binding site | 205 | 1 | Substrate By similarity | ||||||
| Binding site | 365 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029. |
| [2] | "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. Fraser C.M.Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39. |
| [3] | "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138. |
| [4] | "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001363 Genomic DNA. Translation: AAD18391.1. AE002161 Genomic DNA. Translation: AAF73682.1. BA000008 Genomic DNA. Translation: BAA98448.1. AE009440 Genomic DNA. Translation: AAP98177.1. |
| PIR | C72103. F86520. |
| RefSeq | NP_224447.1. NP_300297.1. NP_445068.1. NP_876520.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1466927. 895162. 918927. 962733. |
| GenomeReviews | Gene locus CPn_0238 in contig AE001363_GR. Gene locus CP_0524 in contig AE002161_GR. Gene locus CpB0244 in contig AE009440_GR. Gene locus CPj0238 in contig BA000008_GR. |
| KEGG | cpa:CP0524. cpj:CPj0238. cpn:CPn0238. cpt:CpB0244. |
| TIGR | CP_0524. |
Phylogenomic databases | |
| HOGENOM | HBG322449. |
| OMA | QRADNIE. |
| PhylomeDB | Q9Z8U6. |
Enzyme and pathway databases | |
| BioCyc | CPNE115711:CP_0524-MONOMER. CPNE115713:CPN0238-MONOMER. CPNE138677:CPJ0238-MONOMER. CPNE182082:CPB0244-MONOMER. |
| BRENDA | 1.1.1.49. 264832. |
Family and domain databases | |
| InterPro | IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23429. G6PDH. 1 hit. |
| Pfam | PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000110. G6PD. 1 hit. |
| PRINTS | PR00079. G6PDHDRGNASE. |
| TIGRFAMs | TIGR00871. zwf. 1 hit. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PD_CHLPN | ||||||||
| Accession | Primary (citable) accession number: Q9Z8U6 Secondary accession number(s): Q9JQ22 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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