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Q9Z8U6

- G6PD_CHLPN

UniProt

Q9Z8U6 - G6PD_CHLPN

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, CPn_0238, CP_0524, CPj0238, CpB0244
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611NADP By similarity
Binding sitei171 – 1711NADP By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei205 – 2051Substrate By similarity
Binding sitei239 – 2391Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei263 – 2631Proton acceptor By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei365 – 3651Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1042NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-542-MONOMER.
CPNE115713:GHEY-248-MONOMER.
CPNE138677:GH8N-245-MONOMER.
CPNE182082:GH4N-252-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:CPn_0238, CP_0524, CPj0238, CpB0244
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068116Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0238.

Structurei

3D structure databases

ProteinModelPortaliQ9Z8U6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z8U6-1 [UniParc]FASTAAdd to Basket

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MTNVVQETIG GLNSPRTCPP CILVIFGATG DLTARKLLPA LYHLTKEGRL    50
SDQFVCVGFA RREKSNELFR QEMKQAVIQF SPSELDIKVW EDFQQRLFYH 100
RSEFDNNMGY TSLKDSLEDL DKTYGTRGNR LFYLSTPPQY FSRIIENLNK 150
HKLFYKNQDQ GKPWSRVIIE KPFGRDLDSA KQLQQCINEN LNENSVYHID 200
HYLGKETVQN ILTTRFANTI FESCWNSQYI DHVQISLSET IGIGSRGNFF 250
EKSGMLRDMV QNHMMQLLCL LTMEPPTTFD ADEIRKEKIK ILQRISPFSE 300
GSSIVRGQYG PGTVQGVSVL GYREEENVDK DSRVETYVAL KTVINNPRWL 350
GVPFYLRAGK RLAKKSTDIS IIFKKSPYNL FAAEECSRCP IENDLLIIRI 400
QPDEGVALKF NCKVPGTNNI VRPVKMDFRY DSYFQTTTPE AYERLLCDCI 450
IGDRTLFTGG DEVMASWKLF TPVLEEWDQD SSPSFPNYPA GSSGPKEADA 500
LIERDGRSWR PL 512
Length:512
Mass (Da):58,740
Last modified:May 1, 1999 - v1
Checksum:iEABC8DBFBC940BCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18391.1.
AE002161 Genomic DNA. Translation: AAF73682.1.
BA000008 Genomic DNA. Translation: BAA98448.1.
AE009440 Genomic DNA. Translation: AAP98177.1.
PIRiC72103.
F86520.
RefSeqiNP_224447.1. NC_000922.1.
NP_300297.1. NC_002491.1.
NP_445068.1. NC_002179.2.
NP_876520.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18391; AAD18391; CPn_0238.
AAF73682; AAF73682; CP_0524.
AAP98177; AAP98177; CpB0244.
BAA98448; BAA98448; BAA98448.
GeneIDi1466927.
895162.
918927.
962733.
KEGGicpa:CP0524.
cpj:CPj0238.
cpn:CPn0238.
cpt:CpB0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18391.1 .
AE002161 Genomic DNA. Translation: AAF73682.1 .
BA000008 Genomic DNA. Translation: BAA98448.1 .
AE009440 Genomic DNA. Translation: AAP98177.1 .
PIRi C72103.
F86520.
RefSeqi NP_224447.1. NC_000922.1.
NP_300297.1. NC_002491.1.
NP_445068.1. NC_002179.2.
NP_876520.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z8U6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0238.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18391 ; AAD18391 ; CPn_0238 .
AAF73682 ; AAF73682 ; CP_0524 .
AAP98177 ; AAP98177 ; CpB0244 .
BAA98448 ; BAA98448 ; BAA98448 .
GeneIDi 1466927.
895162.
918927.
962733.
KEGGi cpa:CP0524.
cpj:CPj0238.
cpn:CPn0238.
cpt:CpB0244.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci CPNE115711:GI7B-542-MONOMER.
CPNE115713:GHEY-248-MONOMER.
CPNE138677:GH8N-245-MONOMER.
CPNE182082:GH4N-252-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiG6PD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8U6
Secondary accession number(s): Q9JQ22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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