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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:CPn_0239, CP_0523, CPj0239, CpB0245
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900921 – 2586-phosphogluconolactonaseAdd BLAST258

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0245

Structurei

3D structure databases

ProteinModelPortaliQ9Z8U5
SMRiQ9Z8U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108Q79 Bacteria
COG0363 LUCA
HOGENOMiHOG000256282
KOiK01057
OMAiKQPHLAI
OrthoDBiPOG091H04M8

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z8U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLINFNDT NKLLLTKQPS LFIDLASKDW IASANQAIKQ RGAFYVALSG
60 70 80 90 100
GKTPLEIYKD IVINKDKLID PSKIFLFWGD ERLAPITSSE SNYGQAMSIL
110 120 130 140 150
RDLNIPDEQI FRMETENPDG AKKYQELIEN KIPDASFDMI MLGLGEDGHT
160 170 180 190 200
LSLFSNTSAL EEENDLVVFN SVPHLETERM TLTFPCVHKG KHVVVYVQGE
210 220 230 240 250
NKKPILKSVF FSEGREEKLY PIERVGRDRS PLFWIISPES YDIADFDNIS

SIYKMDIL
Length:258
Mass (Da):29,334
Last modified:May 1, 1999 - v1
Checksum:iE49CA50014ECB797
GO

Sequence cautioni

The sequence AAF73681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP98178 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA98449 differs from that shown. Reason: Erroneous termination at position 42. Translated as Gly.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46V → G in BAA98449 (PubMed:10871362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18392.1
AE002161 Genomic DNA Translation: AAF73681.1 Different initiation.
BA000008 Genomic DNA Translation: BAA98449.1 Sequence problems.
AE009440 Genomic DNA Translation: AAP98178.1 Different initiation.
PIRiD72103
G86520
RefSeqiNP_224448.1, NC_000922.1
WP_010882891.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18392; AAD18392; CPn_0239
AAF73681; AAF73681; CP_0523
AAP98178; AAP98178; CpB0245
BAA98449; BAA98449; BAA98449
GeneIDi895149
KEGGicpa:CP_0523
cpj:devB
cpn:CPn0239
cpt:CpB0245
PATRICifig|115713.3.peg.269

Similar proteinsi

Entry informationi

Entry namei6PGL_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8U5
Secondary accession number(s): Q9JSH4, Q9K256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health