Q9Z8U5 (6PGL_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	CPn_0239, CP_0523, CPj0239, CpB0245

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Sequence caution	The sequence AAF73681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAP98178.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA98449.1 differs from that shown. Reason: Erroneous termination at position 42. Translated as Gly.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	6-phosphogluconolactonase		PRO_0000090092
Experimental info
	Sequence conflict	46	1	V → G in BAA98449. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9Z8U5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: E49CA50014ECB797	FASTA	258	29,334
	10 20 30 40 50 60 MATLINFNDT NKLLLTKQPS LFIDLASKDW IASANQAIKQ RGAFYVALSG GKTPLEIYKD 70 80 90 100 110 120 IVINKDKLID PSKIFLFWGD ERLAPITSSE SNYGQAMSIL RDLNIPDEQI FRMETENPDG 130 140 150 160 170 180 AKKYQELIEN KIPDASFDMI MLGLGEDGHT LSLFSNTSAL EEENDLVVFN SVPHLETERM 190 200 210 220 230 240 TLTFPCVHKG KHVVVYVQGE NKKPILKSVF FSEGREEKLY PIERVGRDRS PLFWIISPES 250 YDIADFDNIS SIYKMDIL

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18392.1. AE002161 Genomic DNA. Translation: AAF73681.1. Different initiation. BA000008 Genomic DNA. Translation: BAA98449.1. Sequence problems. AE009440 Genomic DNA. Translation: AAP98178.1. Different initiation.
PIR	D72103. G86520.
RefSeq	NP_224448.1. NC_000922.1. NP_300298.1. NC_002491.1. NP_445067.1. NC_002179.2. NP_876521.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z8U5.
ModBase	Search...
2D gel databases
PHCI-2DPAGE	Q9Z8U5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1466928. 895149. 918768. 962735.
GenomeReviews	Gene locus CPn_0239 in contig AE001363_GR. Gene locus CP_0523 in contig AE002161_GR. Gene locus CpB0245 in contig AE009440_GR. Gene locus CPj0239 in contig BA000008_GR.
KEGG	cpa:CP0523. cpj:CPj0239. cpn:CPn0239. cpt:CpB0245.
TIGR	CP_0523.
Phylogenomic databases
HOGENOM	HBG725991.
OMA	RLTFTFS.
ProtClustDB	CLSK871240.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0523-MONOMER. CPNE115713:CPN0239-MONOMER. CPNE138677:CPJ0239-MONOMER. CPNE182082:CPB0245-MONOMER.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
KO	K01057.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. Pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_CHLPN

Accession

Primary (citable) accession number: Q9Z8U5
Secondary accession number(s): Q9JSH4, Q9K256

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program