Q9Z8S6 (SURE_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	CPn_0262, CP_0499, CpB0269

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	5'-nucleotidase surE HAMAP MF_00060		PRO_0000111802
Sites
	Metal binding	15	1	Divalent metal cation By similarity
	Metal binding	16	1	Divalent metal cation By similarity
	Metal binding	48	1	Divalent metal cation By similarity
	Metal binding	106	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z8S6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 44C6D977BA792246	FASTA	281	30,478
	10 20 30 40 50 60 MVLMNKRLKI ILTNDDGITA KGMSCLVSAL LEANIGDIYI AAPQAEQSGK SMAISLNQVV 70 80 90 100 110 120 CASPYAYPQP VKEAWAVGGS PTDCVRLGLR TLFESVSPDL VISGINCGNN ICKNAWYSGT 130 140 150 160 170 180 IGAAKQALVD GIPSMALSQD NHISFFQQDK APEILKALVI YLLSQPFPCL TGLNINFPTS 190 200 210 220 230 240 PGGSSWEGMR LVPPGDEFFY EEPQYLGSVN KNQYYVGKIS GVRIGEHPSE ELACMLENHI 250 260 270 280 SVSPIFSQNS PIGLMTLEEF QKTQENFNAS LLSSELTTKI F

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18411.1. AE002161 Genomic DNA. Translation: AAF38328.1. BA000008 Genomic DNA. Translation: BAA98472.1. AE009440 Genomic DNA. Translation: AAP98202.1.
PIR	F72099. F86523.
RefSeq	NP_224467.1. NC_000922.1. NP_300321.1. NC_002491.1. NP_445046.1. NC_002179.2. NP_876545.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z8S6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1466952. 894926. 919034. 963782.
GenomeReviews	Gene locus CPn_0262 in contig AE001363_GR. Gene locus CP_0499 in contig AE002161_GR. Gene locus CpB0269 in contig AE009440_GR. Gene locus surE in contig BA000008_GR.
KEGG	cpa:CP0499. cpn:CPn0262. cpt:CpB0269.
TIGR	CP_0499.
Phylogenomic databases
HOGENOM	HBG600532.
OMA	DCVKMGI.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0499-MONOMER. CPNE115713:CPN0262-MONOMER. CPNE138677:CPJ0262-MONOMER. CPNE182082:CPB0269-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_CHLPN

Accession

Primary (citable) accession number: Q9Z8S6
Secondary accession number(s): Q9JQ93

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program