Q9Z8Q7 (ALF1_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable fructose-bisphosphate aldolase class 1
EC=4.1.2.13

Alternative name(s):
Probable fructose-bisphosphate aldolase class I
Short name=FBP aldolase

Gene names

Name:	fbaB
Ordered Locus Names:	CPn_0281, CP_0477, CpB0289

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. FbaB subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Probable fructose-bisphosphate aldolase class 1		PRO_0000138942
Sites
	Active site	237	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z8Q7 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 69882529D685C7D9	FASTA	349	38,028
	10 20 30 40 50 60 MLNIHDILGN DDENLLSYQC KHITKDKLTL PSHDFVDKVF GLSDRNNRVL RSLQTMFSHG 70 80 90 100 110 120 RLANSGYLSI LPVDQGIEHS AGASFAINPI YFDPENIVKL AIESGCSAVA STYGTLSLLS 130 140 150 160 170 180 RKYAHKIPFM LKLNHNELLS YPTKYHQIFF TQVEAAYSMG AVAVGATVYF GSETSNEEIV 190 200 210 220 230 240 AVSNAFAKAR SLGLATVLWC YLRNPAFVAN GVDYHTAADL TGQADHLGAT LGADIVKQKL 250 260 270 280 290 300 PTCQGGFKAI NFGKTDERVY SELSSNHPID LCRYQVLNSY CGKVGLINSG GPSGKNDFTE 310 320 330 340 AARTAVINKR AGGMGLILGR KAFQRPLSEG IQLLNLVQDI YLDPNITIA

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18430.1. AE002161 Genomic DNA. Translation: AAF38310.1. BA000008 Genomic DNA. Translation: BAA98491.1. AE009440 Genomic DNA. Translation: AAP98222.1.
PIR	A86526. C72097.
RefSeq	NP_224486.1. NC_000922.1. NP_300340.1. NC_002491.1. NP_445024.1. NC_002179.2. NP_876565.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z8Q7.
ModBase	Search...
Protein-protein interaction databases
STRING	115713.CPn0281.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD18430; AAD18430; CPn_0281. AAF38310; AAF38310; CP_0477. AAP98222; AAP98222; CpB0289. BAA98491; BAA98491; BAA98491.
GeneID	1466972. 894851. 919064. 963038.
KEGG	cpa:CP0477. cpj:CPj0281. cpn:CPn0281. cpt:CpB0289.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1830.
HOGENOM	HOG000224791.
KO	K11645.
OMA	RYQVLNC.
ProtClustDB	PRK09250.
Enzyme and pathway databases
BioCyc	CPNE115711:GI7B-477-MONOMER. CPNE115713:GHEY-284-MONOMER. CPNE138677:GH8N-277-MONOMER. CPNE182082:GH4N-290-MONOMER.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR002915. DeoC/FbaB/lacD_aldolase. [Graphical view]
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_CHLPN

Accession

Primary (citable) accession number: Q9Z8Q7
Secondary accession number(s): Q9JQ77

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program