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Q9Z8P2 (FABG_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:CPn_0296, CP_0462, CpB0305
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054670

Regions

Nucleotide binding14 – 174NADP By similarity
Nucleotide binding64 – 652NADP By similarity
Nucleotide binding156 – 1605NADP By similarity

Sites

Active site1561Proton acceptor By similarity
Binding site911NADP; via carbonyl oxygen By similarity
Binding site1431Substrate By similarity
Binding site1891NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z8P2 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 01A2A758B701577E

FASTA24826,505
        10         20         30         40         50         60 
MDITLVGKKV IVTGGSRGIG LGIVKLFLEN GADVEIWGLN EERGQAVIES LTGLGGEVSF 

        70         80         90        100        110        120 
ARVDVSHNGG VKDCVQKFLD KHNKIDILVN NAGITRDNLL MRMSEDDWQS VISTNLTSLY 

       130        140        150        160        170        180 
YTCSSVIRHM IKARSGSIIN VASIVAKIGS AGQTNYAAAK AGIIAFTKSL AKEVAARNIR 

       190        200        210        220        230        240 
VNCLAPGFIE TDMTSVLNDN LKAEWLKSIP LGRAGTPEDV ARVALFLASQ LSSYMTAQTL 


VVDGGLTY

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001363 Genomic DNA. Translation: AAD18445.1.
AE002161 Genomic DNA. Translation: AAF38299.1.
BA000008 Genomic DNA. Translation: BAA98506.1.
AE009440 Genomic DNA. Translation: AAP98238.1.
PIRD72096.
H86527.
RefSeqNP_224501.1. NC_000922.1.
NP_300355.1. NC_002491.1.
NP_445010.1. NC_002179.2.
NP_876581.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z8P2.
ModBaseSearch...

Protein-protein interaction databases

STRING115713.CPn0296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD18445; AAD18445; CPn_0296.
AAF38299; AAF38299; CP_0462.
AAP98238; AAP98238; CpB0305.
BAA98506; BAA98506; BAA98506.
GeneID1466988.
894695.
919066.
963057.
KEGGcpa:CP0462.
cpj:CPj0296.
cpn:CPn0296.
cpt:CpB0305.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMACIAPGCI.
ProtClustDBPRK05653.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-462-MONOMER.
CPNE115713:GHEY-299-MONOMER.
CPNE138677:GH8N-292-MONOMER.
CPNE182082:GH4N-306-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_CHLPN
AccessionPrimary (citable) accession number: Q9Z8P2
Secondary accession number(s): Q9JQD1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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