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Q9Z8P2

- FABG_CHLPN

UniProt

Q9Z8P2 - FABG_CHLPN

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Protein
3-oxoacyl-[acyl-carrier-protein] reductase FabG
Gene
fabG, CPn_0296, CP_0462, CpB0305
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NADP; via carbonyl oxygen By similarity
Binding sitei143 – 1431Substrate By similarity
Active sitei156 – 1561Proton acceptor By similarity
Binding sitei189 – 1891NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 174NADP By similarity
Nucleotide bindingi64 – 652NADP By similarity
Nucleotide bindingi156 – 1605NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-477-MONOMER.
CPNE115713:GHEY-310-MONOMER.
CPNE138677:GH8N-307-MONOMER.
CPNE182082:GH4N-317-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:CPn_0296, CP_0462, CpB0305
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054670Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi115713.CPn0296.

Structurei

3D structure databases

ProteinModelPortaliQ9Z8P2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiDKADWDA.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z8P2-1 [UniParc]FASTAAdd to Basket

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MDITLVGKKV IVTGGSRGIG LGIVKLFLEN GADVEIWGLN EERGQAVIES    50
LTGLGGEVSF ARVDVSHNGG VKDCVQKFLD KHNKIDILVN NAGITRDNLL 100
MRMSEDDWQS VISTNLTSLY YTCSSVIRHM IKARSGSIIN VASIVAKIGS 150
AGQTNYAAAK AGIIAFTKSL AKEVAARNIR VNCLAPGFIE TDMTSVLNDN 200
LKAEWLKSIP LGRAGTPEDV ARVALFLASQ LSSYMTAQTL VVDGGLTY 248
Length:248
Mass (Da):26,505
Last modified:May 1, 1999 - v1
Checksum:i01A2A758B701577E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18445.1.
AE002161 Genomic DNA. Translation: AAF38299.1.
BA000008 Genomic DNA. Translation: BAA98506.1.
AE009440 Genomic DNA. Translation: AAP98238.1.
PIRiD72096.
H86527.
RefSeqiNP_224501.1. NC_000922.1.
NP_300355.1. NC_002491.1.
NP_445010.1. NC_002179.2.
NP_876581.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18445; AAD18445; CPn_0296.
AAF38299; AAF38299; CP_0462.
AAP98238; AAP98238; CpB0305.
BAA98506; BAA98506; BAA98506.
GeneIDi1466988.
894695.
919066.
963057.
KEGGicpa:CP0462.
cpj:CPj0296.
cpn:CPn0296.
cpt:CpB0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18445.1 .
AE002161 Genomic DNA. Translation: AAF38299.1 .
BA000008 Genomic DNA. Translation: BAA98506.1 .
AE009440 Genomic DNA. Translation: AAP98238.1 .
PIRi D72096.
H86527.
RefSeqi NP_224501.1. NC_000922.1.
NP_300355.1. NC_002491.1.
NP_445010.1. NC_002179.2.
NP_876581.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z8P2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18445 ; AAD18445 ; CPn_0296 .
AAF38299 ; AAF38299 ; CP_0462 .
AAP98238 ; AAP98238 ; CpB0305 .
BAA98506 ; BAA98506 ; BAA98506 .
GeneIDi 1466988.
894695.
919066.
963057.
KEGGi cpa:CP0462.
cpj:CPj0296.
cpn:CPn0296.
cpt:CpB0305.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi DKADWDA.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci CPNE115711:GI7B-477-MONOMER.
CPNE115713:GHEY-310-MONOMER.
CPNE138677:GH8N-307-MONOMER.
CPNE182082:GH4N-317-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiFABG_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8P2
Secondary accession number(s): Q9JQD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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