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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NADP; via carbonyl oxygenBy similarity1
Binding sitei143SubstrateBy similarity1
Active sitei156Proton acceptorPROSITE-ProRule annotation1
Binding sitei189NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17NADPBy similarity4
Nucleotide bindingi64 – 65NADPBy similarity2
Nucleotide bindingi156 – 160NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:CPn_0296, CP_0462, CpB0305
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546701 – 2483-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST248

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi182082.CpB0305

Structurei

3D structure databases

ProteinModelPortaliQ9Z8P2
SMRiQ9Z8P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
KOiK00059
OMAiGSRNIRC
OrthoDBiPOG091H012M

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z8P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITLVGKKV IVTGGSRGIG LGIVKLFLEN GADVEIWGLN EERGQAVIES
60 70 80 90 100
LTGLGGEVSF ARVDVSHNGG VKDCVQKFLD KHNKIDILVN NAGITRDNLL
110 120 130 140 150
MRMSEDDWQS VISTNLTSLY YTCSSVIRHM IKARSGSIIN VASIVAKIGS
160 170 180 190 200
AGQTNYAAAK AGIIAFTKSL AKEVAARNIR VNCLAPGFIE TDMTSVLNDN
210 220 230 240
LKAEWLKSIP LGRAGTPEDV ARVALFLASQ LSSYMTAQTL VVDGGLTY
Length:248
Mass (Da):26,505
Last modified:May 1, 1999 - v1
Checksum:i01A2A758B701577E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18445.1
AE002161 Genomic DNA Translation: AAF38299.1
BA000008 Genomic DNA Translation: BAA98506.1
AE009440 Genomic DNA Translation: AAP98238.1
PIRiD72096
H86527
RefSeqiNP_224501.1, NC_000922.1
WP_010882944.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18445; AAD18445; CPn_0296
AAF38299; AAF38299; CP_0462
AAP98238; AAP98238; CpB0305
BAA98506; BAA98506; BAA98506
GeneIDi894695
KEGGicpa:CP_0462
cpj:fabG
cpn:CPn0296
cpt:CpB0305
PATRICifig|115713.3.peg.330

Similar proteinsi

Entry informationi

Entry nameiFABG_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8P2
Secondary accession number(s): Q9JQD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health