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Q9Z8P2

- FABG_CHLPN

UniProt

Q9Z8P2 - FABG_CHLPN

Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei91 – 911NADP; via carbonyl oxygenBy similarity
    Binding sitei143 – 1431SubstrateBy similarity
    Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation
    Binding sitei189 – 1891NADP; via amide nitrogen and carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 174NADPBy similarity
    Nucleotide bindingi64 – 652NADPBy similarity
    Nucleotide bindingi156 – 1605NADPBy similarity

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-477-MONOMER.
    CPNE115713:GHEY-310-MONOMER.
    CPNE138677:GH8N-307-MONOMER.
    CPNE182082:GH4N-317-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
    Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase
    Beta-Ketoacyl-acyl carrier protein reductase
    Beta-ketoacyl-ACP reductase
    Gene namesi
    Name:fabG
    Ordered Locus Names:CPn_0296, CP_0462, CpB0305
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054670Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi115713.CPn0296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z8P2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK00059.
    OMAiDKADWDA.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z8P2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDITLVGKKV IVTGGSRGIG LGIVKLFLEN GADVEIWGLN EERGQAVIES    50
    LTGLGGEVSF ARVDVSHNGG VKDCVQKFLD KHNKIDILVN NAGITRDNLL 100
    MRMSEDDWQS VISTNLTSLY YTCSSVIRHM IKARSGSIIN VASIVAKIGS 150
    AGQTNYAAAK AGIIAFTKSL AKEVAARNIR VNCLAPGFIE TDMTSVLNDN 200
    LKAEWLKSIP LGRAGTPEDV ARVALFLASQ LSSYMTAQTL VVDGGLTY 248
    Length:248
    Mass (Da):26,505
    Last modified:May 1, 1999 - v1
    Checksum:i01A2A758B701577E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18445.1.
    AE002161 Genomic DNA. Translation: AAF38299.1.
    BA000008 Genomic DNA. Translation: BAA98506.1.
    AE009440 Genomic DNA. Translation: AAP98238.1.
    PIRiD72096.
    H86527.
    RefSeqiNP_224501.1. NC_000922.1.
    NP_300355.1. NC_002491.1.
    NP_445010.1. NC_002179.2.
    NP_876581.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18445; AAD18445; CPn_0296.
    AAF38299; AAF38299; CP_0462.
    AAP98238; AAP98238; CpB0305.
    BAA98506; BAA98506; BAA98506.
    GeneIDi1466988.
    894695.
    919066.
    963057.
    KEGGicpa:CP0462.
    cpj:CPj0296.
    cpn:CPn0296.
    cpt:CpB0305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18445.1 .
    AE002161 Genomic DNA. Translation: AAF38299.1 .
    BA000008 Genomic DNA. Translation: BAA98506.1 .
    AE009440 Genomic DNA. Translation: AAP98238.1 .
    PIRi D72096.
    H86527.
    RefSeqi NP_224501.1. NC_000922.1.
    NP_300355.1. NC_002491.1.
    NP_445010.1. NC_002179.2.
    NP_876581.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z8P2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18445 ; AAD18445 ; CPn_0296 .
    AAF38299 ; AAF38299 ; CP_0462 .
    AAP98238 ; AAP98238 ; CpB0305 .
    BAA98506 ; BAA98506 ; BAA98506 .
    GeneIDi 1466988.
    894695.
    919066.
    963057.
    KEGGi cpa:CP0462.
    cpj:CPj0296.
    cpn:CPn0296.
    cpt:CpB0305.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K00059.
    OMAi DKADWDA.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci CPNE115711:GI7B-477-MONOMER.
    CPNE115713:GHEY-310-MONOMER.
    CPNE138677:GH8N-307-MONOMER.
    CPNE182082:GH4N-317-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiFABG_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z8P2
    Secondary accession number(s): Q9JQD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3