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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway:ifatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NADP; via carbonyl oxygenBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation
Binding sitei189 – 1891NADP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 174NADPBy similarity
Nucleotide bindingi64 – 652NADPBy similarity
Nucleotide bindingi156 – 1605NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-477-MONOMER.
CPNE115713:GHEY-310-MONOMER.
CPNE138677:GH8N-307-MONOMER.
CPNE182082:GH4N-317-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:CPn_0296, CP_0462, CpB0305
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000583 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054670Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0296.

Structurei

3D structure databases

ProteinModelPortaliQ9Z8P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiCTQIANL.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z8P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITLVGKKV IVTGGSRGIG LGIVKLFLEN GADVEIWGLN EERGQAVIES
60 70 80 90 100
LTGLGGEVSF ARVDVSHNGG VKDCVQKFLD KHNKIDILVN NAGITRDNLL
110 120 130 140 150
MRMSEDDWQS VISTNLTSLY YTCSSVIRHM IKARSGSIIN VASIVAKIGS
160 170 180 190 200
AGQTNYAAAK AGIIAFTKSL AKEVAARNIR VNCLAPGFIE TDMTSVLNDN
210 220 230 240
LKAEWLKSIP LGRAGTPEDV ARVALFLASQ LSSYMTAQTL VVDGGLTY
Length:248
Mass (Da):26,505
Last modified:May 1, 1999 - v1
Checksum:i01A2A758B701577E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18445.1.
AE002161 Genomic DNA. Translation: AAF38299.1.
BA000008 Genomic DNA. Translation: BAA98506.1.
AE009440 Genomic DNA. Translation: AAP98238.1.
PIRiD72096.
H86527.
RefSeqiNP_224501.1. NC_000922.1.

Genome annotation databases

EnsemblBacteriaiAAD18445; AAD18445; CPn_0296.
AAF38299; AAF38299; CP_0462.
AAP98238; AAP98238; CpB0305.
BAA98506; BAA98506; BAA98506.
GeneIDi894695.
KEGGicpa:CP0462.
cpj:CPj0296.
cpn:CPn0296.
cpt:CpB0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18445.1.
AE002161 Genomic DNA. Translation: AAF38299.1.
BA000008 Genomic DNA. Translation: BAA98506.1.
AE009440 Genomic DNA. Translation: AAP98238.1.
PIRiD72096.
H86527.
RefSeqiNP_224501.1. NC_000922.1.

3D structure databases

ProteinModelPortaliQ9Z8P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18445; AAD18445; CPn_0296.
AAF38299; AAF38299; CP_0462.
AAP98238; AAP98238; CpB0305.
BAA98506; BAA98506; BAA98506.
GeneIDi894695.
KEGGicpa:CP0462.
cpj:CPj0296.
cpn:CPn0296.
cpt:CpB0305.

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiCTQIANL.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciCPNE115711:GI7B-477-MONOMER.
CPNE115713:GHEY-310-MONOMER.
CPNE138677:GH8N-307-MONOMER.
CPNE182082:GH4N-317-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiFABG_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8P2
Secondary accession number(s): Q9JQD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.