Q9Z8P2 (FABG_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100

Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase

Gene names

Name:	fabG
Ordered Locus Names:	CPn_0296, CP_0462, CpB0305

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	3-oxoacyl-[acyl-carrier-protein] reductase FabG		PRO_0000054670
Regions
	Nucleotide binding	14 – 17	4	NADP By similarity
	Nucleotide binding	64 – 65	2	NADP By similarity
	Nucleotide binding	156 – 160	5	NADP By similarity
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	91	1	NADP; via carbonyl oxygen By similarity
	Binding site	143	1	Substrate By similarity
	Binding site	189	1	NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z8P2 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 01A2A758B701577E	FASTA	248	26,505
	10 20 30 40 50 60 MDITLVGKKV IVTGGSRGIG LGIVKLFLEN GADVEIWGLN EERGQAVIES LTGLGGEVSF 70 80 90 100 110 120 ARVDVSHNGG VKDCVQKFLD KHNKIDILVN NAGITRDNLL MRMSEDDWQS VISTNLTSLY 130 140 150 160 170 180 YTCSSVIRHM IKARSGSIIN VASIVAKIGS AGQTNYAAAK AGIIAFTKSL AKEVAARNIR 190 200 210 220 230 240 VNCLAPGFIE TDMTSVLNDN LKAEWLKSIP LGRAGTPEDV ARVALFLASQ LSSYMTAQTL VVDGGLTY

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18445.1. AE002161 Genomic DNA. Translation: AAF38299.1. BA000008 Genomic DNA. Translation: BAA98506.1. AE009440 Genomic DNA. Translation: AAP98238.1.
PIR	D72096. H86527.
RefSeq	NP_224501.1. NC_000922.1. NP_300355.1. NC_002491.1. NP_445010.1. NC_002179.2. NP_876581.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z8P2.
ModBase	Search...
2D gel databases
PHCI-2DPAGE	Q9Z8P2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1466988. 894695. 919066. 963057.
GenomeReviews	Gene locus CPn_0296 in contig AE001363_GR. Gene locus CP_0462 in contig AE002161_GR. Gene locus CpB0305 in contig AE009440_GR. Gene locus fabG in contig BA000008_GR.
KEGG	cpa:CP0462. cpn:CPn0296. cpt:CpB0305.
TIGR	CP_0462.
Phylogenomic databases
HOGENOM	HBG750976.
OMA	CIAPGCI.
ProtClustDB	PRK05653.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0462-MONOMER. CPNE115713:CPN0296-MONOMER. CPNE138677:CPJ0296-MONOMER. CPNE182082:CPB0305-MONOMER.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00059.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_CHLPN

Accession

Primary (citable) accession number: Q9Z8P2
Secondary accession number(s): Q9JQD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program