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Reviewed, UniProtKB/Swiss-Prot Q9Z8M4 (TRXB_CHLPN)

Last modified June 16, 2009. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thioredoxin reductase
      Short name=TRXR
    EC=1.8.1.9
Gene names
Name: trxB
Ordered Locus Names: CPn_0314, CP_0444, CpB0322
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

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Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

removal of superoxide radicals

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

electron carrier activity

Inferred from electronic annotation. Source: InterPro

thioredoxin-disulfide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Thioredoxin reductase
PRO_0000166725

Regions

Nucleotide binding33 – 4311FAD By similarity
Nucleotide binding283 – 29210FAD By similarity

Amino acid modifications

Disulfide bond138 ↔ 141Redox-active By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9Z8M4-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 352C5E87865C2B27

FASTA31133,559
        10         20         30         40         50         60 
MIHSRLIIIG SGPSGYTAAI YASRALLHPL LFEGFFSGIS GGQLMTTTEV ENFPGFPEGI 

        70         80         90        100        110        120 
LGPKLMNNMK EQAVRFGTKT LAQDIISVDF SVRPFILKSK EETYSCDACI IATGASAKRL 

       130        140        150        160        170        180 
EIPGAGNDEF WQKGVTACAV CDGASPIFKN KDLYVIGGGD SALEEALYLT RYGSHVYVVH 

       190        200        210        220        230        240 
RRDKLRASKA MEARAQNNEK ITFLWNSEIV KISGDSIVRS VDIKNVQTQE ITTREAAGVF 

       250        260        270        280        290        300 
FAIGHKPNTD FLGGQLTLDE SGYIVTEKGT SKTSVPGVFA AGDVQDKYYR QAVTSAGSGC 

       310 
IAALDAERFL G

« Hide

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References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

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Cross-references

Sequence databases

AE001363 Genomic DNA. Translation: AAD18463.1.
AE002161 Genomic DNA. Translation: AAF38283.1.
BA000008 Genomic DNA. Translation: BAA98524.1.
AE017158 Genomic DNA. Translation: AAP98256.1.
PIRB86530.
C72093.
RefSeqNP_224519.1.
NP_300373.1.
NP_444992.1.
NP_876599.1.

3D structure databases

HSSPHSSP built from PDB template 1VDC based on UniProtKB Q39243.
ModBaseSearch...

2-D gel databases

PHCI-2DPAGEQ9Z8M4.

Genome annotation databases

GeneID1467006.
894975.
919090.
963713.
GenomeReviewsGene locus CPn_0314 in contig AE001363_GR.
Gene locus CP_0444 in contig AE002161_GR.
Gene locus CpB0322 in contig AE009440_GR.
Gene locus trxB in contig BA000008_GR.
KEGGcpa:CP0444.
cpn:CPn0314.
cpt:CpB0322.
TIGRCP_0444.

Phylogenomic databases

HOGENOMQ9Z8M4.
OMAQ9Z8M4. WDSAIDE.

Enzyme and pathway databases

BioCycCPNE115711:CP_0444-MON.
CPNE115713:CPN0314-MON.
CPNE138677:CPJ0314-MON.
CPNE182082:CPB0322-MON.
BRENDA1.8.1.9. 264832.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR001327. Pyr_OxRdtase_NAD_bd.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProDomPD000139. FAD_pyr_redox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01292. TRX_reduct. 1 hit.
PROSITEPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTRXB_CHLPN
AccessionPrimary (citable) accession number: Q9Z8M4
Secondary accession number(s): Q9JQJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents