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Protein

Thioredoxin reductase

Gene

trxB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 4311FADBy similarityAdd
BLAST
Nucleotide bindingi283 – 29210FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-459-MONOMER.
CPNE115713:GHEY-328-MONOMER.
CPNE138677:GH8N-325-MONOMER.
CPNE182082:GH4N-335-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:CPn_0314, CP_0444, CpB0322
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Thioredoxin reductasePRO_0000166725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi138 ↔ 141Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0314.

Structurei

3D structure databases

ProteinModelPortaliQ9Z8M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072912.
KOiK00384.
OMAiGQLEMNN.
OrthoDBiPOG091H02HU.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z8M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSRLIIIG SGPSGYTAAI YASRALLHPL LFEGFFSGIS GGQLMTTTEV
60 70 80 90 100
ENFPGFPEGI LGPKLMNNMK EQAVRFGTKT LAQDIISVDF SVRPFILKSK
110 120 130 140 150
EETYSCDACI IATGASAKRL EIPGAGNDEF WQKGVTACAV CDGASPIFKN
160 170 180 190 200
KDLYVIGGGD SALEEALYLT RYGSHVYVVH RRDKLRASKA MEARAQNNEK
210 220 230 240 250
ITFLWNSEIV KISGDSIVRS VDIKNVQTQE ITTREAAGVF FAIGHKPNTD
260 270 280 290 300
FLGGQLTLDE SGYIVTEKGT SKTSVPGVFA AGDVQDKYYR QAVTSAGSGC
310
IAALDAERFL G
Length:311
Mass (Da):33,559
Last modified:May 1, 1999 - v1
Checksum:i352C5E87865C2B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18463.1.
AE002161 Genomic DNA. Translation: AAF38283.1.
BA000008 Genomic DNA. Translation: BAA98524.1.
AE009440 Genomic DNA. Translation: AAP98256.1.
PIRiB86530.
C72093.
RefSeqiNP_224519.1. NC_000922.1.
WP_010882962.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18463; AAD18463; CPn_0314.
AAF38283; AAF38283; CP_0444.
AAP98256; AAP98256; CpB0322.
BAA98524; BAA98524; BAA98524.
GeneIDi894975.
KEGGicpa:CP_0444.
cpj:trxB.
cpn:CPn0314.
cpt:CpB0322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18463.1.
AE002161 Genomic DNA. Translation: AAF38283.1.
BA000008 Genomic DNA. Translation: BAA98524.1.
AE009440 Genomic DNA. Translation: AAP98256.1.
PIRiB86530.
C72093.
RefSeqiNP_224519.1. NC_000922.1.
WP_010882962.1. NZ_LN847257.1.

3D structure databases

ProteinModelPortaliQ9Z8M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18463; AAD18463; CPn_0314.
AAF38283; AAF38283; CP_0444.
AAP98256; AAP98256; CpB0322.
BAA98524; BAA98524; BAA98524.
GeneIDi894975.
KEGGicpa:CP_0444.
cpj:trxB.
cpn:CPn0314.
cpt:CpB0322.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072912.
KOiK00384.
OMAiGQLEMNN.
OrthoDBiPOG091H02HU.

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-459-MONOMER.
CPNE115713:GHEY-328-MONOMER.
CPNE138677:GH8N-325-MONOMER.
CPNE182082:GH4N-335-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXB_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8M4
Secondary accession number(s): Q9JQJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.