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Protein

Thioredoxin reductase

Gene

trxB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 43FADBy similarityAdd BLAST11
Nucleotide bindingi283 – 292FADBy similarity10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:CPn_0314, CP_0444, CpB0322
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667251 – 311Thioredoxin reductaseAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi138 ↔ 141Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi182082.CpB0322

Structurei

3D structure databases

ProteinModelPortaliQ9Z8M4
SMRiQ9Z8M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M Bacteria
COG0492 LUCA
HOGENOMiHOG000072912
KOiK00384
OMAiDPIQGPW
OrthoDBiPOG091H02HU

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z8M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSRLIIIG SGPSGYTAAI YASRALLHPL LFEGFFSGIS GGQLMTTTEV
60 70 80 90 100
ENFPGFPEGI LGPKLMNNMK EQAVRFGTKT LAQDIISVDF SVRPFILKSK
110 120 130 140 150
EETYSCDACI IATGASAKRL EIPGAGNDEF WQKGVTACAV CDGASPIFKN
160 170 180 190 200
KDLYVIGGGD SALEEALYLT RYGSHVYVVH RRDKLRASKA MEARAQNNEK
210 220 230 240 250
ITFLWNSEIV KISGDSIVRS VDIKNVQTQE ITTREAAGVF FAIGHKPNTD
260 270 280 290 300
FLGGQLTLDE SGYIVTEKGT SKTSVPGVFA AGDVQDKYYR QAVTSAGSGC
310
IAALDAERFL G
Length:311
Mass (Da):33,559
Last modified:May 1, 1999 - v1
Checksum:i352C5E87865C2B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18463.1
AE002161 Genomic DNA Translation: AAF38283.1
BA000008 Genomic DNA Translation: BAA98524.1
AE009440 Genomic DNA Translation: AAP98256.1
PIRiB86530
C72093
RefSeqiNP_224519.1, NC_000922.1
WP_010882962.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18463; AAD18463; CPn_0314
AAF38283; AAF38283; CP_0444
AAP98256; AAP98256; CpB0322
BAA98524; BAA98524; BAA98524
GeneIDi894975
KEGGicpa:CP_0444
cpj:trxB
cpn:CPn0314
cpt:CpB0322
PATRICifig|115713.3.peg.348

Similar proteinsi

Entry informationi

Entry nameiTRXB_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8M4
Secondary accession number(s): Q9JQJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health