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Q9Z8I3

- 6PGD_CHLPN

UniProt

Q9Z8I3 - 6PGD_CHLPN

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADPBy similarity
Binding sitei102 – 1021SubstrateBy similarity
Active sitei182 – 1821Proton acceptorBy similarity
Active sitei189 – 1891Proton donorBy similarity
Binding sitei190 – 1901SubstrateBy similarity
Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
Binding sitei286 – 2861SubstrateBy similarity
Binding sitei446 – 4461Substrate; shared with dimeric partnerBy similarity
Binding sitei452 – 4521Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPBy similarity
Nucleotide bindingi32 – 343NADPBy similarity
Nucleotide bindingi74 – 763NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-413-MONOMER.
CPNE115713:GHEY-374-MONOMER.
CPNE138677:GH8N-369-MONOMER.
CPNE182082:GH4N-379-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:CPn_0360, CP_0398, CpB0369
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4794796-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090032Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0360.

Structurei

3D structure databases

ProteinModelPortaliQ9Z8I3.
SMRiQ9Z8I3. Positions 2-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1303Substrate bindingBy similarity
Regioni185 – 1862Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiNSHEDKS.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z8I3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTNIGLIGL AVMGKNLVLN MIDHGFSVSV YNRTPEKTRD FLKEYPNHRE
60 70 80 90 100
LVGFESLEDF VNSLERPRKI MLMIQAGKPV DQSIHALLPF LEPGDVIIDG
110 120 130 140 150
GNSYFKDSER RCKELQEKGI LFLGVGISGG EEGARHGPSI MPGGNPEAWP
160 170 180 190 200
LVAPIFQSIA AKVQGRPCCS WVGTGGAGHY VKAVHNGIEY GDIQLICEAY
210 220 230 240 250
GILRDFLKLS ATAVATILKE WNTLELESYL IRIASEVLAL KDPEGIPVID
260 270 280 290 300
TILDVVGQKG TGKWTAIDAL NSGVPLSLII GAVLARFLSS WKEIREQAAR
310 320 330 340 350
NYPGTPLIFE MPHDPSVFIQ DVFHALYASK IISYAQGFML LGEASKEYNW
360 370 380 390 400
GLDLGEIALM WRGGCIIQSA FLDVIHKGFA ANPENTSLIF QEYFRGALRH
410 420 430 440 450
AEMGWRRTVV TAIGAGLPIP CLAAAITFYD GYRTASSSMS LAQGLRDYFG
460 470
AHTYERNDRP RGEFYHTDWV HTKTTERVK
Length:479
Mass (Da):52,939
Last modified:May 1, 1999 - v1
Checksum:i0FD301D3378E11F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18504.1.
AE002161 Genomic DNA. Translation: AAF38243.1.
BA000008 Genomic DNA. Translation: BAA98568.1.
AE009440 Genomic DNA. Translation: AAP98300.1.
PIRiC72088.
F86535.
RefSeqiNP_224560.1. NC_000922.1.
NP_300417.1. NC_002491.1.
NP_444947.1. NC_002179.2.
NP_876643.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18504; AAD18504; CPn_0360.
AAF38243; AAF38243; CP_0398.
AAP98300; AAP98300; CpB0369.
BAA98568; BAA98568; BAA98568.
GeneIDi1467050.
895135.
919866.
963777.
KEGGicpa:CP0398.
cpj:CPj0360.
cpn:CPn0360.
cpt:CpB0369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18504.1 .
AE002161 Genomic DNA. Translation: AAF38243.1 .
BA000008 Genomic DNA. Translation: BAA98568.1 .
AE009440 Genomic DNA. Translation: AAP98300.1 .
PIRi C72088.
F86535.
RefSeqi NP_224560.1. NC_000922.1.
NP_300417.1. NC_002491.1.
NP_444947.1. NC_002179.2.
NP_876643.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z8I3.
SMRi Q9Z8I3. Positions 2-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18504 ; AAD18504 ; CPn_0360 .
AAF38243 ; AAF38243 ; CP_0398 .
AAP98300 ; AAP98300 ; CpB0369 .
BAA98568 ; BAA98568 ; BAA98568 .
GeneIDi 1467050.
895135.
919866.
963777.
KEGGi cpa:CP0398.
cpj:CPj0360.
cpn:CPn0360.
cpt:CpB0369.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi NSHEDKS.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci CPNE115711:GI7B-413-MONOMER.
CPNE115713:GHEY-374-MONOMER.
CPNE138677:GH8N-369-MONOMER.
CPNE182082:GH4N-379-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry namei6PGD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8I3
Secondary accession number(s): Q9JQC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3