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Q9Z8I3

- 6PGD_CHLPN

UniProt

Q9Z8I3 - 6PGD_CHLPN

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021NADPBy similarity
    Binding sitei102 – 1021SubstrateBy similarity
    Active sitei182 – 1821Proton acceptorBy similarity
    Active sitei189 – 1891Proton donorBy similarity
    Binding sitei190 – 1901SubstrateBy similarity
    Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
    Binding sitei286 – 2861SubstrateBy similarity
    Binding sitei446 – 4461Substrate; shared with dimeric partnerBy similarity
    Binding sitei452 – 4521Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPBy similarity
    Nucleotide bindingi32 – 343NADPBy similarity
    Nucleotide bindingi74 – 763NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-413-MONOMER.
    CPNE115713:GHEY-374-MONOMER.
    CPNE138677:GH8N-369-MONOMER.
    CPNE182082:GH4N-379-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:CPn_0360, CP_0398, CpB0369
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4794796-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090032Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi115713.CPn0360.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z8I3.
    SMRiQ9Z8I3. Positions 2-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1303Substrate bindingBy similarity
    Regioni185 – 1862Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OMAiNSHEDKS.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z8I3-1 [UniParc]FASTAAdd to Basket

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    MQTNIGLIGL AVMGKNLVLN MIDHGFSVSV YNRTPEKTRD FLKEYPNHRE    50
    LVGFESLEDF VNSLERPRKI MLMIQAGKPV DQSIHALLPF LEPGDVIIDG 100
    GNSYFKDSER RCKELQEKGI LFLGVGISGG EEGARHGPSI MPGGNPEAWP 150
    LVAPIFQSIA AKVQGRPCCS WVGTGGAGHY VKAVHNGIEY GDIQLICEAY 200
    GILRDFLKLS ATAVATILKE WNTLELESYL IRIASEVLAL KDPEGIPVID 250
    TILDVVGQKG TGKWTAIDAL NSGVPLSLII GAVLARFLSS WKEIREQAAR 300
    NYPGTPLIFE MPHDPSVFIQ DVFHALYASK IISYAQGFML LGEASKEYNW 350
    GLDLGEIALM WRGGCIIQSA FLDVIHKGFA ANPENTSLIF QEYFRGALRH 400
    AEMGWRRTVV TAIGAGLPIP CLAAAITFYD GYRTASSSMS LAQGLRDYFG 450
    AHTYERNDRP RGEFYHTDWV HTKTTERVK 479
    Length:479
    Mass (Da):52,939
    Last modified:May 1, 1999 - v1
    Checksum:i0FD301D3378E11F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18504.1.
    AE002161 Genomic DNA. Translation: AAF38243.1.
    BA000008 Genomic DNA. Translation: BAA98568.1.
    AE009440 Genomic DNA. Translation: AAP98300.1.
    PIRiC72088.
    F86535.
    RefSeqiNP_224560.1. NC_000922.1.
    NP_300417.1. NC_002491.1.
    NP_444947.1. NC_002179.2.
    NP_876643.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18504; AAD18504; CPn_0360.
    AAF38243; AAF38243; CP_0398.
    AAP98300; AAP98300; CpB0369.
    BAA98568; BAA98568; BAA98568.
    GeneIDi1467050.
    895135.
    919866.
    963777.
    KEGGicpa:CP0398.
    cpj:CPj0360.
    cpn:CPn0360.
    cpt:CpB0369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18504.1 .
    AE002161 Genomic DNA. Translation: AAF38243.1 .
    BA000008 Genomic DNA. Translation: BAA98568.1 .
    AE009440 Genomic DNA. Translation: AAP98300.1 .
    PIRi C72088.
    F86535.
    RefSeqi NP_224560.1. NC_000922.1.
    NP_300417.1. NC_002491.1.
    NP_444947.1. NC_002179.2.
    NP_876643.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z8I3.
    SMRi Q9Z8I3. Positions 2-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18504 ; AAD18504 ; CPn_0360 .
    AAF38243 ; AAF38243 ; CP_0398 .
    AAP98300 ; AAP98300 ; CpB0369 .
    BAA98568 ; BAA98568 ; BAA98568 .
    GeneIDi 1467050.
    895135.
    919866.
    963777.
    KEGGi cpa:CP0398.
    cpj:CPj0360.
    cpn:CPn0360.
    cpt:CpB0369.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OMAi NSHEDKS.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci CPNE115711:GI7B-413-MONOMER.
    CPNE115713:GHEY-374-MONOMER.
    CPNE138677:GH8N-369-MONOMER.
    CPNE182082:GH4N-379-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry namei6PGD_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z8I3
    Secondary accession number(s): Q9JQC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3