ID   Q9Z8G5_CHLPN            Unreviewed;       908 AA.
AC   Q9Z8G5; Q7AIW3; Q7BXF4; Q7DER5;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 147.
DE   SubName: Full=Oxoglutarate Dehydrogenase {ECO:0000313|EMBL:AAD18522.1, ECO:0000313|EMBL:CRI37993.1};
DE            EC=1.2.4.2 {ECO:0000313|EMBL:CRI37993.1};
DE   SubName: Full=2-oxoglutarate dehydrogenase, E1 component {ECO:0000313|EMBL:AAF38225.1};
GN   Name=sucA {ECO:0000313|EMBL:AAD18522.1};
GN   OrderedLocusNames=CP_0378 {ECO:0000313|EMBL:AAF38225.1}, CPn_0378
GN   {ECO:0000313|EMBL:AAD18522.1};
GN   ORFNames=BN1224_CV15_B_03160 {ECO:0000313|EMBL:CRI37993.1},
GN   BN1224_GiD_A_03920 {ECO:0000313|EMBL:CRI41391.1}, BN1224_H12_DW_00100
GN   {ECO:0000313|EMBL:CRI43614.1}, BN1224_MUL2216_E_01160
GN   {ECO:0000313|EMBL:CRI45855.1}, BN1224_Panola_F_00480
GN   {ECO:0000313|EMBL:CRI46985.1}, BN1224_PB1_B_03780
GN   {ECO:0000313|EMBL:CRI50409.1}, BN1224_U1271_C_02190
GN   {ECO:0000313|EMBL:CRI49279.1}, BN1224_UZG1_A_03910
GN   {ECO:0000313|EMBL:CRI51536.1}, BN1224_Wien2_G_00150
GN   {ECO:0000313|EMBL:CRI52801.1}, BN1224_YK41_BN_00160
GN   {ECO:0000313|EMBL:CRI73028.1}, CWL029c_C_02190
GN   {ECO:0000313|EMBL:CRI40259.1};
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558 {ECO:0000313|Proteomes:UP000000583};
RN   [1] {ECO:0000313|EMBL:AAD18522.1, ECO:0000313|Proteomes:UP000000801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029 {ECO:0000313|EMBL:AAD18522.1,
RC   ECO:0000313|Proteomes:UP000000801};
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W., Marathe R., Lammel C., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2] {ECO:0000313|EMBL:AAF38225.1, ECO:0000313|Proteomes:UP000000583}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39 {ECO:0000313|EMBL:AAF38225.1,
RC   ECO:0000313|Proteomes:UP000000583};
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3] {ECO:0000313|EMBL:CRI37993.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CV15 {ECO:0000313|EMBL:CRI37993.1}, CWL029c
RC   {ECO:0000313|EMBL:CRI40259.1}, GiD {ECO:0000313|EMBL:CRI41391.1}, H12
RC   {ECO:0000313|EMBL:CRI43614.1}, MUL2216 {ECO:0000313|EMBL:CRI45855.1},
RC   Panola {ECO:0000313|EMBL:CRI46985.1}, PB1
RC   {ECO:0000313|EMBL:CRI50409.1}, U1271 {ECO:0000313|EMBL:CRI49279.1},
RC   UZG1 {ECO:0000313|EMBL:CRI51536.1}, Wien2
RC   {ECO:0000313|EMBL:CRI52801.1}, and YK41 {ECO:0000313|EMBL:CRI73028.1};
RA   Rattei Thomas;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; AE001363; AAD18522.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38225.1; -; Genomic_DNA.
DR   EMBL; LN846998; CRI37993.1; -; Genomic_DNA.
DR   EMBL; LN847003; CRI40259.1; -; Genomic_DNA.
DR   EMBL; LN847008; CRI41391.1; -; Genomic_DNA.
DR   EMBL; LN847177; CRI43614.1; -; Genomic_DNA.
DR   EMBL; LN847226; CRI45855.1; -; Genomic_DNA.
DR   EMBL; LN847232; CRI46985.1; -; Genomic_DNA.
DR   EMBL; LN847244; CRI49279.1; -; Genomic_DNA.
DR   EMBL; LN847240; CRI50409.1; -; Genomic_DNA.
DR   EMBL; LN847245; CRI51536.1; -; Genomic_DNA.
DR   EMBL; LN847254; CRI52801.1; -; Genomic_DNA.
DR   EMBL; LN849039; CRI73028.1; -; Genomic_DNA.
DR   PIR; G72085; G72085.
DR   PIR; H86537; H86537.
DR   RefSeq; NP_224578.1; NC_000922.1.
DR   RefSeq; WP_010883021.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z8G5; -.
DR   STRING; 406984.CPK_ORF00887; -.
DR   GeneID; 45050425; -.
DR   KEGG; cpa:CP_0378; -.
DR   KEGG; cpn:CPn_0378; -.
DR   PATRIC; fig|115713.3.peg.420; -.
DR   eggNOG; COG0567; Bacteria.
DR   HOGENOM; CLU_004709_1_0_0; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CRI37993.1};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          569..762
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   908 AA;  103470 MW;  F6B29DA79FA8146D CRC64;
     MDSEFVGQVY SSDMDWIESM YQRFMNHETL DPSWKYFFEG YQLGQAASPS EASTKISGNE
     TIAMLQEQKS QFLCTIYRYY GYLQSQISTL APTTDSRFIQ EKIAKIDLDE QVPSAGLLPK
     AQVSVRELIE ALKKCYCGSL TLETLTCTPE LQEFVWNLME KRQVERFAEQ LLRSYKDLCK
     ATFFEEFLQI KFTGQKRFSL EGGETLVPML EHLVHYGSAL GISNYVLGMA HRGRLNVLTN
     VLGKPYRYVF MEFEDDPAAR GLESVGDVKY HKGYVLKSHQ KDRETTFVML PNASHLESVD
     PIVEGVVAAL QHQGHAGKEQ SSLAILVHGD AAFSGQGVVY ETLQLSRVPG YSTEGTLHIV
     VNNYIGFTAV PRESRSTPYC TDIAKMLGIP VFRVNSEDVV ACIEAIEYAL QVRERFSCDV
     IIDLCCYRKY GHNESDDPSV TAPLLYDQIK RKKSIRELFR QYLLEGQFAD ISEETLASIE
     KEIQESLNRE FQVLKGTDPE PFPKKECHHC DRLNNGELIL HDCDVSLDRE TLFHMSSRLC
     GFPDNFHPHP KIKTLLEKRM KMAEGGVGYD WAMAEELAFA SLLIEGYNLR LSGQDSIRGT
     FSQRHLVWSD TVTGDTYSPL YHLSAEQGSV EMYNSPLSEY AILGFEYGYA QQALKTLVLW
     EAQFGDFANG AQIIFDQYIS SGIQKWDLHS DIVLLLPHGY EGQGPEHSSS RIERYLQLAA
     NWNFQVVLPS TPVQYFRILR EHAKRDLSLP LVIFTPKLLL RYPQCVSSIE EFTEPGGFRA
     ILEDADPNYD ASILVLCSGK IYYDYAEMLP QDRRKDFSCL RIESLYPLAL EDLVSLIDKY
     SHLKHFVWLQ EESKNMGAYD YMFMALQDIL PEKLLYIGRP RSSSTASGSA KLSRQELVTC
     METLFSLR
//