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Protein

dCTP deaminase

Gene

dcd

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd), dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut), Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139Proton donor/acceptorUniRule annotation1
Binding sitei158dCTPUniRule annotation1
Binding sitei172dCTPUniRule annotation1
Binding sitei181dCTPUniRule annotation1
Binding sitei182dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi113 – 118dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:CPn_0392, CP_0363, CpB0404
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559761 – 190dCTP deaminaseAdd BLAST190

Proteomic databases

PRIDEiQ9Z8F1

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0404

Structurei

3D structure databases

ProteinModelPortaliQ9Z8F1
SMRiQ9Z8F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228600
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z8F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKEDKWIR EMALNADMIH PFVNGQVNVN EETGEKLISY GLSSYGYDLR
60 70 80 90 100
LSREFKVFTN VYNSVVDPKC FTEDIFISIT DDVCIVPPNS FALARSVEYF
110 120 130 140 150
RIPRNVLTMC IGKSTYARCG IIVNVTPFEP EWEGHVTIEI SNTTPLPAKI
160 170 180 190
YANEGIAQVL FFESSTTCEV SYADRKGKYQ KQQGITVPCV
Length:190
Mass (Da):21,475
Last modified:May 1, 1999 - v1
Checksum:i7F1DB26849E63B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18535.1
AE002161 Genomic DNA Translation: AAF38212.1
BA000008 Genomic DNA Translation: BAA98600.1
AE009440 Genomic DNA Translation: AAP98335.1
PIRiF72084
F86539
RefSeqiNP_224592.1, NC_000922.1
WP_010883035.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18535; AAD18535; CPn_0392
AAF38212; AAF38212; CP_0363
AAP98335; AAP98335; CpB0404
BAA98600; BAA98600; BAA98600
GeneIDi894877
KEGGicpa:CP_0363
cpj:dcd
cpn:CPn0392
cpt:CpB0404
PATRICifig|115713.3.peg.434

Similar proteinsi

Entry informationi

Entry nameiDCD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8F1
Secondary accession number(s): Q9JQ65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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