Reviewed, UniProtKB/Swiss-Prot Q9Z8F1 (DCD_CHLPN)

Names and origin

Protein names

Recommended name:
    Deoxycytidine triphosphate deaminase
      Short name=dCTP deaminase
    EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	CPn_0392, CP_0363, CpB0404

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_0000155976

Sequences

	Sequence		Length	Mass (Da)
	Q9Z8F1-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 7F1DB26849E63B7F	FASTA	190	21,475
	10 20 30 40 50 60 MSIKEDKWIR EMALNADMIH PFVNGQVNVN EETGEKLISY GLSSYGYDLR LSREFKVFTN 70 80 90 100 110 120 VYNSVVDPKC FTEDIFISIT DDVCIVPPNS FALARSVEYF RIPRNVLTMC IGKSTYARCG 130 140 150 160 170 180 IIVNVTPFEP EWEGHVTIEI SNTTPLPAKI YANEGIAQVL FFESSTTCEV SYADRKGKYQ 190 KQQGITVPCV

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18535.1. AE002161 Genomic DNA. Translation: AAF38212.1. BA000008 Genomic DNA. Translation: BAA98600.1. AE009440 Genomic DNA. Translation: AAP98335.1.
PIR	F72084. F86539.
RefSeq	NP_224592.1. NP_300449.1. NP_444911.1. NP_876678.1.
3D structure databases
SMR	Q9Z8F1. Positions 3-188.
ModBase	Search...
Genome annotation databases
GeneID	1467085. 894877. 919239. 963059.
GenomeReviews	Gene locus CPn_0392 in contig AE001363_GR. Gene locus CP_0363 in contig AE002161_GR. Gene locus CpB0404 in contig AE009440_GR. Gene locus dcd in contig BA000008_GR.
KEGG	cpa:CP0363. cpn:CPn0392. cpt:CpB0404.
TIGR	CP_0363.
Phylogenomic databases
HOGENOM	HBG553199.
OMA	MEYFRIP.
PhylomeDB	Q9Z8F1.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0363-MONOMER. CPNE115713:CPN0392-MONOMER. CPNE138677:CPJ0392-MONOMER. CPNE182082:CPB0404-MONOMER.
BRENDA	3.5.4.13. 264832.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. DeoxyUTP_pyroPase_dom. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_CHLPN

Accession

Primary (citable) accession number: Q9Z8F1
Secondary accession number(s): Q9JQ65

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)