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Q9Z8C5

- MURE_CHLPN

UniProt

Q9Z8C5 - MURE_CHLPN

Protein

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Gene

murE

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.UniRule annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diamino-heptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301UDP-MurNAc-L-Ala-D-GluUniRule annotation
    Binding sitei178 – 1781UDP-MurNAc-L-Ala-D-GluUniRule annotation
    Binding sitei186 – 1861UDP-MurNAc-L-Ala-D-GluUniRule annotation
    Binding sitei380 – 3801Meso-diaminopimelateUniRule annotation
    Binding sitei453 – 4531Meso-diaminopimelate; via carbonyl oxygenUniRule annotation
    Binding sitei457 – 4571Meso-diaminopimelateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi109 – 1157ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-349-MONOMER.
    CPNE115713:GHEY-434-MONOMER.
    CPNE138677:GH8N-429-MONOMER.
    CPNE182082:GH4N-446-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligaseUniRule annotation (EC:6.3.2.13UniRule annotation)
    Alternative name(s):
    Meso-A2pm-adding enzymeUniRule annotation
    Meso-diaminopimelate-adding enzymeUniRule annotation
    UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligaseUniRule annotation
    UDP-MurNAc-tripeptide synthetaseUniRule annotation
    UDP-N-acetylmuramyl-tripeptide synthetaseUniRule annotation
    Gene namesi
    Name:murEUniRule annotation
    Ordered Locus Names:CPn_0418, CP_0336, CpB0434
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligasePRO_0000101881Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei218 – 2181N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamoylation is probably crucial for Mg2+ binding and, consequently, for the gamma-phosphate positioning of ATP.UniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0418.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z8C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 1522UDP-MurNAc-L-Ala-D-Glu bindingUniRule annotation
    Regioni403 – 4064Meso-diaminopimelate bindingUniRule annotation

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi403 – 4064Meso-diaminopimelate recognition motif

    Sequence similaritiesi

    Belongs to the MurCDEF family. MurE subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0769.
    HOGENOMiHOG000268118.
    KOiK01928.
    OMAiAVMTNLS.
    OrthoDBiEOG6PKFCR.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00208. MurE.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005761. UDP-N-AcMur-Glu-dNH2Pim_ligase.
    [Graphical view]
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsiTIGR01085. murE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z8C5-1 [UniParc]FASTAAdd to Basket

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    MDLKELLHGV QAKIYGKVRP LEVRNLTRDS RCVSVGDIFI AHKGQRYDGN    50
    DFAVDALANG AIAIASSLYN PFLSVVQIIT PNLEELEAEL SAKYYEYPSS 100
    KLHTIGVTGT NGKTTVTCLI KALLDSYQKP SGLLGTIEHI LGEGVIKDGF 150
    TTPTPALLQK YLATMVRQNR DAVVMEVSSI GLASGRVAYT NFDTAVLTNI 200
    TLDHLDFHGT FETYVAAKAK LFSLVPPSGM VVINTDSPYA SQCIESAKAP 250
    VITYGIESAA DYRATDIQLS SSGTKYTLVY GDQKIACSSS FIGKYNVYNL 300
    LAAISTVHAS LRCDLEDLLE KIGLCQPPPG RLDPVLMGPC PVYIDYAHTP 350
    DALDNVLTGL HELLPEGGRL IVVFGCGGDR DRSKRKLMAQ VVERYGFAVV 400
    TSDNPRSEPP EDIVNEICDG FYSKNYFIEI DRKQAITYAL SIASDRDIVL 450
    IAGKGHEAYQ IFKHQTVAFD DKQTVCEVLA SYV 483
    Length:483
    Mass (Da):52,720
    Last modified:May 1, 1999 - v1
    Checksum:i3A0FEEA93EDD76ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18562.1.
    AE002161 Genomic DNA. Translation: AAF38190.1.
    BA000008 Genomic DNA. Translation: BAA98626.1.
    AE009440 Genomic DNA. Translation: AAP98365.1.
    PIRiD72080.
    H86542.
    RefSeqiNP_224618.1. NC_000922.1.
    NP_300475.1. NC_002491.1.
    NP_444885.1. NC_002179.2.
    NP_876708.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18562; AAD18562; CPn_0418.
    AAF38190; AAF38190; CP_0336.
    AAP98365; AAP98365; CpB0434.
    BAA98626; BAA98626; BAA98626.
    GeneIDi1467115.
    894904.
    919161.
    962867.
    KEGGicpa:CP0336.
    cpj:CPj0418.
    cpn:CPn0418.
    cpt:CpB0434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18562.1 .
    AE002161 Genomic DNA. Translation: AAF38190.1 .
    BA000008 Genomic DNA. Translation: BAA98626.1 .
    AE009440 Genomic DNA. Translation: AAP98365.1 .
    PIRi D72080.
    H86542.
    RefSeqi NP_224618.1. NC_000922.1.
    NP_300475.1. NC_002491.1.
    NP_444885.1. NC_002179.2.
    NP_876708.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z8C5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0418.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18562 ; AAD18562 ; CPn_0418 .
    AAF38190 ; AAF38190 ; CP_0336 .
    AAP98365 ; AAP98365 ; CpB0434 .
    BAA98626 ; BAA98626 ; BAA98626 .
    GeneIDi 1467115.
    894904.
    919161.
    962867.
    KEGGi cpa:CP0336.
    cpj:CPj0418.
    cpn:CPn0418.
    cpt:CpB0434.

    Phylogenomic databases

    eggNOGi COG0769.
    HOGENOMi HOG000268118.
    KOi K01928.
    OMAi AVMTNLS.
    OrthoDBi EOG6PKFCR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CPNE115711:GI7B-349-MONOMER.
    CPNE115713:GHEY-434-MONOMER.
    CPNE138677:GH8N-429-MONOMER.
    CPNE182082:GH4N-446-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00208. MurE.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005761. UDP-N-AcMur-Glu-dNH2Pim_ligase.
    [Graphical view ]
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsi TIGR01085. murE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiMURE_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z8C5
    Secondary accession number(s): Q9JQA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3