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Q9Z856

- DAPAT_CHLPN

UniProt

Q9Z856 - DAPAT_CHLPN

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Protein

LL-diaminopimelate aminotransferase

Gene
dapL, CPn_0495, CP_0259, CPj0495, CpB0515
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogen By similarity
Binding sitei71 – 711Pyridoxal phosphate; shared with dimeric partner By similarity
Binding sitei74 – 741Substrate; shared with dimeric partner By similarity
Binding sitei105 – 1051Substrate By similarity
Binding sitei128 – 1281Substrate By similarity
Binding sitei174 – 1741Pyridoxal phosphate By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei202 – 2021Pyridoxal phosphate By similarity
Binding sitei205 – 2051Pyridoxal phosphate By similarity
Binding sitei233 – 2331Pyridoxal phosphate By similarity
Binding sitei235 – 2351Pyridoxal phosphate By similarity
Binding sitei244 – 2441Pyridoxal phosphate By similarity
Binding sitei275 – 2751Substrate; shared with dimeric partner By similarity
Binding sitei368 – 3681Substrate By similarity

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-272-MONOMER.
CPNE115713:GHEY-511-MONOMER.
CPNE138677:GH8N-504-MONOMER.
CPNE182082:GH4N-525-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase (EC:2.6.1.83)
Short name:
DAP-AT
Short name:
DAP-aminotransferase
Short name:
LL-DAP-aminotransferase
Gene namesi
Name:dapL
Ordered Locus Names:CPn_0495, CP_0259, CPj0495, CpB0515
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397LL-diaminopimelate aminotransferaseUniRule annotationPRO_0000342219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0495.

Structurei

3D structure databases

ProteinModelPortaliQ9Z856.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OMAiKWVDYAN.
OrthoDBiEOG6XWV2X.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z856-1 [UniParc]FASTAAdd to Basket

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MRRNPHFSLL KPQYLFSEIS KKLAQFRKEN PEISVIDLSI GDTTQPLCRS    50
ITQAIKEFCV SQEKQETYRG YGPETGLEKL RTKIASEVYE NRISPEEIFI 100
SDGAKPDIFR LFSFFGSEKT LGLQDPVYPA YRDIAHITGI RDIIPLACRK 150
ETGFIPELPN QQSLDILCLC YPNNPTGTVL TFQQLQALVN YANQHGTVLI 200
FDAAYSAFVS DPSLPKSIFE IPEAKYCAIE INSFSKSLGF TGMRLAWNVI 250
PKELTYDNNE PMINDWKRLF ATTFNGASLL MQEAGYYGLD LFPTPPAISL 300
YLTNAQKLKK SLETAGFSVH GGDHAPYLWV ELPEGISDEE AFDFFLHQYH 350
IAVTPGHGFG SCGQGFVRFS ALTQPQNIAL ACDRLCTASL KETMVLA 397
Length:397
Mass (Da):44,491
Last modified:May 1, 1999 - v1
Checksum:i42D7A6C97983D137
GO

Sequence cautioni

The sequence AAP98444.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18635.1.
AE002161 Genomic DNA. Translation: AAF73649.1.
BA000008 Genomic DNA. Translation: BAA98701.1.
AE009440 Genomic DNA. Translation: AAP98444.1. Different initiation.
PIRiC86552.
F72072.
RefSeqiNP_224691.1. NC_000922.1.
NP_300550.1. NC_002491.1.
NP_444810.1. NC_002179.2.
NP_876787.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18635; AAD18635; CPn_0495.
AAF73649; AAF73649; CP_0259.
AAP98444; AAP98444; CpB0515.
BAA98701; BAA98701; BAA98701.
GeneIDi1467194.
895445.
919237.
962904.
KEGGicpa:CP0259.
cpj:CPj0495.
cpn:CPn0495.
cpt:CpB0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18635.1 .
AE002161 Genomic DNA. Translation: AAF73649.1 .
BA000008 Genomic DNA. Translation: BAA98701.1 .
AE009440 Genomic DNA. Translation: AAP98444.1 . Different initiation.
PIRi C86552.
F72072.
RefSeqi NP_224691.1. NC_000922.1.
NP_300550.1. NC_002491.1.
NP_444810.1. NC_002179.2.
NP_876787.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z856.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0495.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18635 ; AAD18635 ; CPn_0495 .
AAF73649 ; AAF73649 ; CP_0259 .
AAP98444 ; AAP98444 ; CpB0515 .
BAA98701 ; BAA98701 ; BAA98701 .
GeneIDi 1467194.
895445.
919237.
962904.
KEGGi cpa:CP0259.
cpj:CPj0495.
cpn:CPn0495.
cpt:CpB0515.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223061.
KOi K10206.
OMAi KWVDYAN.
OrthoDBi EOG6XWV2X.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci CPNE115711:GI7B-272-MONOMER.
CPNE115713:GHEY-511-MONOMER.
CPNE138677:GH8N-504-MONOMER.
CPNE182082:GH4N-525-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiDAPAT_CHLPN
AccessioniPrimary (citable) accession number: Q9Z856
Secondary accession number(s): Q7AIP4, Q7DEX0, Q7VPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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