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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL), LL-diaminopimelate aminotransferase (dapL), LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei41Substrate; via amide nitrogenUniRule annotation1
Binding sitei71Pyridoxal phosphateUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Binding sitei128Pyridoxal phosphateUniRule annotation1
Binding sitei128SubstrateUniRule annotation1
Binding sitei174Pyridoxal phosphateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Binding sitei205Pyridoxal phosphateUniRule annotation1
Binding sitei244Pyridoxal phosphateUniRule annotation1
Binding sitei275Pyridoxal phosphateUniRule annotation1
Binding sitei275SubstrateUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:CPn_0495, CP_0259, CPj0495, CpB0515
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422191 – 397LL-diaminopimelate aminotransferaseAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0515

Structurei

3D structure databases

ProteinModelPortaliQ9Z856
SMRiQ9Z856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Pyridoxal phosphate bindingUniRule annotation2
Regioni233 – 235Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RB0 Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNPHFSLL KPQYLFSEIS KKLAQFRKEN PEISVIDLSI GDTTQPLCRS
60 70 80 90 100
ITQAIKEFCV SQEKQETYRG YGPETGLEKL RTKIASEVYE NRISPEEIFI
110 120 130 140 150
SDGAKPDIFR LFSFFGSEKT LGLQDPVYPA YRDIAHITGI RDIIPLACRK
160 170 180 190 200
ETGFIPELPN QQSLDILCLC YPNNPTGTVL TFQQLQALVN YANQHGTVLI
210 220 230 240 250
FDAAYSAFVS DPSLPKSIFE IPEAKYCAIE INSFSKSLGF TGMRLAWNVI
260 270 280 290 300
PKELTYDNNE PMINDWKRLF ATTFNGASLL MQEAGYYGLD LFPTPPAISL
310 320 330 340 350
YLTNAQKLKK SLETAGFSVH GGDHAPYLWV ELPEGISDEE AFDFFLHQYH
360 370 380 390
IAVTPGHGFG SCGQGFVRFS ALTQPQNIAL ACDRLCTASL KETMVLA
Length:397
Mass (Da):44,491
Last modified:May 1, 1999 - v1
Checksum:i42D7A6C97983D137
GO

Sequence cautioni

The sequence AAP98444 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18635.1
AE002161 Genomic DNA Translation: AAF73649.1
BA000008 Genomic DNA Translation: BAA98701.1
AE009440 Genomic DNA Translation: AAP98444.1 Different initiation.
PIRiC86552
F72072
RefSeqiNP_224691.1, NC_000922.1
WP_010883133.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18635; AAD18635; CPn_0495
AAF73649; AAF73649; CP_0259
AAP98444; AAP98444; CpB0515
BAA98701; BAA98701; BAA98701
GeneIDi895445
KEGGicpa:CP_0259
cpj:aspC
cpn:CPn0495
cpt:CpB0515
PATRICifig|115713.3.peg.554

Similar proteinsi

Entry informationi

Entry nameiDAPAT_CHLPN
AccessioniPrimary (citable) accession number: Q9Z856
Secondary accession number(s): Q7AIP4, Q7DEX0, Q7VPZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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