Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogenUniRule annotation
Binding sitei71 – 711Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
Binding sitei74 – 741Substrate; shared with dimeric partnerUniRule annotation
Binding sitei105 – 1051SubstrateUniRule annotation
Binding sitei128 – 1281SubstrateUniRule annotation
Binding sitei174 – 1741Pyridoxal phosphateUniRule annotation
Binding sitei174 – 1741SubstrateUniRule annotation
Binding sitei202 – 2021Pyridoxal phosphateUniRule annotation
Binding sitei205 – 2051Pyridoxal phosphateUniRule annotation
Binding sitei233 – 2331Pyridoxal phosphateUniRule annotation
Binding sitei235 – 2351Pyridoxal phosphateUniRule annotation
Binding sitei244 – 2441Pyridoxal phosphateUniRule annotation
Binding sitei275 – 2751Substrate; shared with dimeric partnerUniRule annotation
Binding sitei368 – 3681SubstrateUniRule annotation

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-272-MONOMER.
CPNE115713:GHEY-511-MONOMER.
CPNE138677:GH8N-504-MONOMER.
CPNE182082:GH4N-525-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:CPn_0495, CP_0259, CPj0495, CpB0515
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000802 Componenti: Chromosome UP000000583 Componenti: Chromosome UP000000801 Componenti: Chromosome UP000000424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397LL-diaminopimelate aminotransferasePRO_0000342219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0495.

Structurei

3D structure databases

ProteinModelPortaliQ9Z856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OMAiTGTRCAF.
OrthoDBiEOG6XWV2X.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNPHFSLL KPQYLFSEIS KKLAQFRKEN PEISVIDLSI GDTTQPLCRS
60 70 80 90 100
ITQAIKEFCV SQEKQETYRG YGPETGLEKL RTKIASEVYE NRISPEEIFI
110 120 130 140 150
SDGAKPDIFR LFSFFGSEKT LGLQDPVYPA YRDIAHITGI RDIIPLACRK
160 170 180 190 200
ETGFIPELPN QQSLDILCLC YPNNPTGTVL TFQQLQALVN YANQHGTVLI
210 220 230 240 250
FDAAYSAFVS DPSLPKSIFE IPEAKYCAIE INSFSKSLGF TGMRLAWNVI
260 270 280 290 300
PKELTYDNNE PMINDWKRLF ATTFNGASLL MQEAGYYGLD LFPTPPAISL
310 320 330 340 350
YLTNAQKLKK SLETAGFSVH GGDHAPYLWV ELPEGISDEE AFDFFLHQYH
360 370 380 390
IAVTPGHGFG SCGQGFVRFS ALTQPQNIAL ACDRLCTASL KETMVLA
Length:397
Mass (Da):44,491
Last modified:May 1, 1999 - v1
Checksum:i42D7A6C97983D137
GO

Sequence cautioni

The sequence AAP98444.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18635.1.
AE002161 Genomic DNA. Translation: AAF73649.1.
BA000008 Genomic DNA. Translation: BAA98701.1.
AE009440 Genomic DNA. Translation: AAP98444.1. Different initiation.
PIRiC86552.
F72072.
RefSeqiNP_224691.1. NC_000922.1.
NP_300550.1. NC_002491.1.
NP_444810.1. NC_002179.2.
NP_876787.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18635; AAD18635; CPn_0495.
AAF73649; AAF73649; CP_0259.
AAP98444; AAP98444; CpB0515.
BAA98701; BAA98701; BAA98701.
GeneIDi895445.
962904.
KEGGicpa:CP0259.
cpj:CPj0495.
cpn:CPn0495.
cpt:CpB0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18635.1.
AE002161 Genomic DNA. Translation: AAF73649.1.
BA000008 Genomic DNA. Translation: BAA98701.1.
AE009440 Genomic DNA. Translation: AAP98444.1. Different initiation.
PIRiC86552.
F72072.
RefSeqiNP_224691.1. NC_000922.1.
NP_300550.1. NC_002491.1.
NP_444810.1. NC_002179.2.
NP_876787.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9Z856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18635; AAD18635; CPn_0495.
AAF73649; AAF73649; CP_0259.
AAP98444; AAP98444; CpB0515.
BAA98701; BAA98701; BAA98701.
GeneIDi895445.
962904.
KEGGicpa:CP0259.
cpj:CPj0495.
cpn:CPn0495.
cpt:CpB0515.

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OMAiTGTRCAF.
OrthoDBiEOG6XWV2X.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466.
BioCyciCPNE115711:GI7B-272-MONOMER.
CPNE115713:GHEY-511-MONOMER.
CPNE138677:GH8N-504-MONOMER.
CPNE182082:GH4N-525-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiDAPAT_CHLPN
AccessioniPrimary (citable) accession number: Q9Z856
Secondary accession number(s): Q7AIP4, Q7DEX0, Q7VPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.