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Q9Z833

- DAPF_CHLPN

UniProt

Q9Z833 - DAPF_CHLPN

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Protein
Diaminopimelate epimerase
Gene
dapF, CPn_0519, CP_0234, CpB0540
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Substrate By similarity
Binding sitei45 – 451Substrate By similarity
Binding sitei63 – 631Substrate By similarity
Active sitei72 – 721Proton donor/acceptor By similarity
Sitei147 – 1471Important for catalytic activity By similarity
Binding sitei179 – 1791Substrate By similarity
Sitei197 – 1971Important for catalytic activity By similarity
Active sitei207 – 2071Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-247-MONOMER.
CPNE115713:GHEY-535-MONOMER.
CPNE138677:GH8N-528-MONOMER.
CPNE182082:GH4N-550-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:CPn_0519, CP_0234, CpB0540
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Diaminopimelate epimeraseUniRule annotation
PRO_0000149831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 207UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0519.

Structurei

3D structure databases

ProteinModelPortaliQ9Z833.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 743Substrate binding By similarity
Regioni197 – 1982Substrate binding By similarity
Regioni208 – 2092Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiNGLRCVI.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z833-1 [UniParc]FASTAAdd to Basket

« Hide

MAFYSPSTIS KYFIYSGAGN RFLLGETLPE VEDVRFLCQE TRVDGFLYLK    50
PSSCADAQLI IFNSDGSRPT MCGNGLRCAI AHLASQKGKS DISVSTDSGL 100
YSGYFYSWDR VLVDMTLADW RASVHRLESR PDPLPKEVVC IHTGVPHAVV 150
ILPEISTLDL SILGPFLRYH QTFSPDGVNV NFVQILGHCQ LRVRTYERGV 200
EGETAACGTG ALASALVVSN SYGWKESIQI HTWGGELMTV SQNRGRVYLQ 250
GSVTRDL 257
Length:257
Mass (Da):28,323
Last modified:May 1, 1999 - v1
Checksum:iD0679450E24FADA0
GO

Sequence cautioni

The sequence AAP98469.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18659.1.
AE002161 Genomic DNA. Translation: AAF73646.1.
BA000008 Genomic DNA. Translation: BAA98725.1.
AE009440 Genomic DNA. Translation: AAP98469.1. Different initiation.
PIRiC86555.
F72067.
RefSeqiNP_224715.1. NC_000922.1.
NP_300574.1. NC_002491.1.
NP_444785.1. NC_002179.2.
NP_876812.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18659; AAD18659; CPn_0519.
AAF73646; AAF73646; CP_0234.
AAP98469; AAP98469; CpB0540.
BAA98725; BAA98725; BAA98725.
GeneIDi1467219.
895298.
919276.
963818.
KEGGicpa:CP0234.
cpj:CPj0519.
cpn:CPn0519.
cpt:CpB0540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18659.1 .
AE002161 Genomic DNA. Translation: AAF73646.1 .
BA000008 Genomic DNA. Translation: BAA98725.1 .
AE009440 Genomic DNA. Translation: AAP98469.1 . Different initiation.
PIRi C86555.
F72067.
RefSeqi NP_224715.1. NC_000922.1.
NP_300574.1. NC_002491.1.
NP_444785.1. NC_002179.2.
NP_876812.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z833.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18659 ; AAD18659 ; CPn_0519 .
AAF73646 ; AAF73646 ; CP_0234 .
AAP98469 ; AAP98469 ; CpB0540 .
BAA98725 ; BAA98725 ; BAA98725 .
GeneIDi 1467219.
895298.
919276.
963818.
KEGGi cpa:CP0234.
cpj:CPj0519.
cpn:CPn0519.
cpt:CpB0540.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi NGLRCVI.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci CPNE115711:GI7B-247-MONOMER.
CPNE115713:GHEY-535-MONOMER.
CPNE138677:GH8N-528-MONOMER.
CPNE182082:GH4N-550-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiDAPF_CHLPN
AccessioniPrimary (citable) accession number: Q9Z833
Secondary accession number(s): Q9JQ32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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