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Protein

Riboflavin synthase

Gene

ribE

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribE)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei132Lumazine 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:CPn_0532, CP_0220, CpB0553
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681641 – 200Riboflavin synthaseAdd BLAST200

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi182082.CpB0553

Structurei

3D structure databases

ProteinModelPortaliQ9Z820
SMRiQ9Z820
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 97Lumazine-binding 1Add BLAST97
Repeati98 – 190Lumazine-binding 2Add BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 6Lumazine 1 bindingBy similarity3
Regioni48 – 50Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni62 – 67Lumazine 2 binding; shared with one trimeric partnerBy similarity6
Regioni101 – 103Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni141 – 143Lumazine 1 bindingBy similarity3
Regioni155 – 160Lumazine 1 bindingBy similarity6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108R6K Bacteria
COG0307 LUCA
HOGENOMiHOG000151758
KOiK00793
OMAiHFVTGHV
OrthoDBiPOG091H00EJ

Family and domain databases

CDDicd00402 Riboflavin_synthase_like, 1 hit
Gene3Di2.40.30.20, 2 hits
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR001783 Lumazine-bd
IPR026017 Lumazine-bd_dom
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR21098 PTHR21098, 1 hit
PfamiView protein in Pfam
PF00677 Lum_binding, 2 hits
PIRSFiPIRSF000498 Riboflavin_syn_A, 1 hit
SUPFAMiSSF63380 SSF63380, 2 hits
TIGRFAMsiTIGR00187 ribE, 1 hit
PROSITEiView protein in PROSITE
PS51177 LUMAZINE_BIND, 2 hits

Sequencei

Sequence statusi: Complete.

Q9Z820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGIIQELG EVCFFEAQGN GLSLGIKSTP LFVTPLVTGD SVAVDGVCLT
60 70 80 90 100
LTSCNESKIF FDVIPETLAC TTLGEKRCSD QVNLEAALKM GDSIGGHLLS
110 120 130 140 150
GHVFGTAEIF LIKENRYYFR GSKELSQYLF EKGFIAIDGI SLTLVSVDSD
160 170 180 190 200
TFSVGLIPET LQRTTLGKKR EGERVNIEID MSTKIQVDTV KRILASSGKD
Length:200
Mass (Da):21,701
Last modified:May 1, 1999 - v1
Checksum:iCB92A79CA7FB9202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18672.1
AE002161 Genomic DNA Translation: AAF38089.1
BA000008 Genomic DNA Translation: BAA98738.1
AE009440 Genomic DNA Translation: AAP98482.1
PIRiE72066
H86556
RefSeqiNP_224728.1, NC_000922.1
WP_010883170.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18672; AAD18672; CPn_0532
AAF38089; AAF38089; CP_0220
AAP98482; AAP98482; CpB0553
BAA98738; BAA98738; BAA98738
GeneIDi895387
KEGGicpa:CP_0220
cpj:ribC
cpn:CPn0532
cpt:CpB0553
PATRICifig|115713.3.peg.592

Entry informationi

Entry nameiRISA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z820
Secondary accession number(s): Q9JQ33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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