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Q9Z820

- RISA_CHLPN

UniProt

Q9Z820 - RISA_CHLPN

Protein

Riboflavin synthase

Gene

ribE

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

    Catalytic activityi

    2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity Source: InterPro
    2. riboflavin synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-233-MONOMER.
    CPNE115713:GHEY-549-MONOMER.
    CPNE138677:GH8N-541-MONOMER.
    CPNE182082:GH4N-563-MONOMER.
    UniPathwayiUPA00275; UER00405.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin synthase (EC:2.5.1.9)
    Short name:
    RS
    Gene namesi
    Name:ribE
    Synonyms:ribC
    Ordered Locus Names:CPn_0532, CP_0220, CpB0553
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Riboflavin synthasePRO_0000068164Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi115713.CPn0532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z820.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 9797Lumazine-binding 1Add
    BLAST
    Repeati98 – 19093Lumazine-binding 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4 – 63Substrate bindingBy similarity
    Regioni48 – 503Substrate bindingBy similarity
    Regioni62 – 676Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 2 lumazine-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0307.
    HOGENOMiHOG000151758.
    KOiK00793.
    OMAiNIIPYTW.
    OrthoDBiEOG6VMTQH.

    Family and domain databases

    Gene3Di2.40.30.20. 2 hits.
    InterProiIPR023366. ATPase_asu-like.
    IPR001783. Lumazine-bd.
    IPR026017. Lumazine-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PANTHERiPTHR21098. PTHR21098. 1 hit.
    PfamiPF00677. Lum_binding. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
    SUPFAMiSSF63380. SSF63380. 2 hits.
    TIGRFAMsiTIGR00187. ribE. 1 hit.
    PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z820-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSGIIQELG EVCFFEAQGN GLSLGIKSTP LFVTPLVTGD SVAVDGVCLT    50
    LTSCNESKIF FDVIPETLAC TTLGEKRCSD QVNLEAALKM GDSIGGHLLS 100
    GHVFGTAEIF LIKENRYYFR GSKELSQYLF EKGFIAIDGI SLTLVSVDSD 150
    TFSVGLIPET LQRTTLGKKR EGERVNIEID MSTKIQVDTV KRILASSGKD 200
    Length:200
    Mass (Da):21,701
    Last modified:May 1, 1999 - v1
    Checksum:iCB92A79CA7FB9202
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18672.1.
    AE002161 Genomic DNA. Translation: AAF38089.1.
    BA000008 Genomic DNA. Translation: BAA98738.1.
    AE009440 Genomic DNA. Translation: AAP98482.1.
    PIRiE72066.
    H86556.
    RefSeqiNP_224728.1. NC_000922.1.
    NP_300587.1. NC_002491.1.
    NP_444771.1. NC_002179.2.
    NP_876825.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18672; AAD18672; CPn_0532.
    AAF38089; AAF38089; CP_0220.
    AAP98482; AAP98482; CpB0553.
    BAA98738; BAA98738; BAA98738.
    GeneIDi1467232.
    895387.
    919295.
    963827.
    KEGGicpa:CP0220.
    cpj:CPj0532.
    cpn:CPn0532.
    cpt:CpB0553.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18672.1 .
    AE002161 Genomic DNA. Translation: AAF38089.1 .
    BA000008 Genomic DNA. Translation: BAA98738.1 .
    AE009440 Genomic DNA. Translation: AAP98482.1 .
    PIRi E72066.
    H86556.
    RefSeqi NP_224728.1. NC_000922.1.
    NP_300587.1. NC_002491.1.
    NP_444771.1. NC_002179.2.
    NP_876825.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z820.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0532.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18672 ; AAD18672 ; CPn_0532 .
    AAF38089 ; AAF38089 ; CP_0220 .
    AAP98482 ; AAP98482 ; CpB0553 .
    BAA98738 ; BAA98738 ; BAA98738 .
    GeneIDi 1467232.
    895387.
    919295.
    963827.
    KEGGi cpa:CP0220.
    cpj:CPj0532.
    cpn:CPn0532.
    cpt:CpB0553.

    Phylogenomic databases

    eggNOGi COG0307.
    HOGENOMi HOG000151758.
    KOi K00793.
    OMAi NIIPYTW.
    OrthoDBi EOG6VMTQH.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00405 .
    BioCyci CPNE115711:GI7B-233-MONOMER.
    CPNE115713:GHEY-549-MONOMER.
    CPNE138677:GH8N-541-MONOMER.
    CPNE182082:GH4N-563-MONOMER.

    Family and domain databases

    Gene3Di 2.40.30.20. 2 hits.
    InterProi IPR023366. ATPase_asu-like.
    IPR001783. Lumazine-bd.
    IPR026017. Lumazine-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    PANTHERi PTHR21098. PTHR21098. 1 hit.
    Pfami PF00677. Lum_binding. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000498. Riboflavin_syn_A. 1 hit.
    SUPFAMi SSF63380. SSF63380. 2 hits.
    TIGRFAMsi TIGR00187. ribE. 1 hit.
    PROSITEi PS51177. LUMAZINE_BIND. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiRISA_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z820
    Secondary accession number(s): Q9JQ33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3