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Q9Z820 (RISA_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Riboflavin synthase

Short name=RS
EC=2.5.1.9
Gene names
Name:ribE
Synonyms:ribC
Ordered Locus Names:CPn_0532, CP_0220, CpB0553
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil By similarity.

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Contains 2 lumazine-binding repeats.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   DomainRepeat
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: InterPro

riboflavin synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Riboflavin synthase
PRO_0000068164

Regions

Repeat1 – 9797Lumazine-binding 1
Repeat98 – 19093Lumazine-binding 2
Region4 – 63Substrate binding By similarity
Region48 – 503Substrate binding By similarity
Region62 – 676Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z820 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: CB92A79CA7FB9202

FASTA20021,701
        10         20         30         40         50         60 
MFSGIIQELG EVCFFEAQGN GLSLGIKSTP LFVTPLVTGD SVAVDGVCLT LTSCNESKIF 

        70         80         90        100        110        120 
FDVIPETLAC TTLGEKRCSD QVNLEAALKM GDSIGGHLLS GHVFGTAEIF LIKENRYYFR 

       130        140        150        160        170        180 
GSKELSQYLF EKGFIAIDGI SLTLVSVDSD TFSVGLIPET LQRTTLGKKR EGERVNIEID 

       190        200 
MSTKIQVDTV KRILASSGKD 

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001363 Genomic DNA. Translation: AAD18672.1.
AE002161 Genomic DNA. Translation: AAF38089.1.
BA000008 Genomic DNA. Translation: BAA98738.1.
AE009440 Genomic DNA. Translation: AAP98482.1.
PIRE72066.
H86556.
RefSeqNP_224728.1. NC_000922.1.
NP_300587.1. NC_002491.1.
NP_444771.1. NC_002179.2.
NP_876825.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z820.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING115713.CPn0532.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD18672; AAD18672; CPn_0532.
AAF38089; AAF38089; CP_0220.
AAP98482; AAP98482; CpB0553.
BAA98738; BAA98738; BAA98738.
GeneID1467232.
895387.
919295.
963827.
KEGGcpa:CP0220.
cpj:CPj0532.
cpn:CPn0532.
cpt:CpB0553.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0307.
HOGENOMHOG000151758.
KOK00793.
OMAVVNIERA.
OrthoDBEOG6VMTQH.
ProtClustDBPRK09289.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-233-MONOMER.
CPNE115713:GHEY-549-MONOMER.
CPNE138677:GH8N-541-MONOMER.
CPNE182082:GH4N-563-MONOMER.
UniPathwayUPA00275; UER00405.

Family and domain databases

Gene3D2.40.30.20. 2 hits.
InterProIPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERPTHR21098. PTHR21098. 1 hit.
PfamPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMSSF63380. SSF63380. 2 hits.
TIGRFAMsTIGR00187. ribE. 1 hit.
PROSITEPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRISA_CHLPN
AccessionPrimary (citable) accession number: Q9Z820
Secondary accession number(s): Q9JQ33
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 13, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways