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Protein

Riboflavin synthase

Gene

ribE

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity Source: InterPro
  2. riboflavin synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-233-MONOMER.
CPNE115713:GHEY-549-MONOMER.
CPNE138677:GH8N-541-MONOMER.
CPNE182082:GH4N-563-MONOMER.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:CPn_0532, CP_0220, CpB0553
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Riboflavin synthasePRO_0000068164Add
BLAST

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0532.

Structurei

3D structure databases

ProteinModelPortaliQ9Z820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 9797Lumazine-binding 1Add
BLAST
Repeati98 – 19093Lumazine-binding 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 63Substrate bindingBy similarity
Regioni48 – 503Substrate bindingBy similarity
Regioni62 – 676Substrate bindingBy similarity

Sequence similaritiesi

Contains 2 lumazine-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0307.
HOGENOMiHOG000151758.
KOiK00793.
OMAiHILSGHV.
OrthoDBiEOG6VMTQH.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiIPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGIIQELG EVCFFEAQGN GLSLGIKSTP LFVTPLVTGD SVAVDGVCLT
60 70 80 90 100
LTSCNESKIF FDVIPETLAC TTLGEKRCSD QVNLEAALKM GDSIGGHLLS
110 120 130 140 150
GHVFGTAEIF LIKENRYYFR GSKELSQYLF EKGFIAIDGI SLTLVSVDSD
160 170 180 190 200
TFSVGLIPET LQRTTLGKKR EGERVNIEID MSTKIQVDTV KRILASSGKD
Length:200
Mass (Da):21,701
Last modified:May 1, 1999 - v1
Checksum:iCB92A79CA7FB9202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18672.1.
AE002161 Genomic DNA. Translation: AAF38089.1.
BA000008 Genomic DNA. Translation: BAA98738.1.
AE009440 Genomic DNA. Translation: AAP98482.1.
PIRiE72066.
H86556.
RefSeqiNP_224728.1. NC_000922.1.
NP_300587.1. NC_002491.1.
NP_444771.1. NC_002179.2.
NP_876825.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18672; AAD18672; CPn_0532.
AAF38089; AAF38089; CP_0220.
AAP98482; AAP98482; CpB0553.
BAA98738; BAA98738; BAA98738.
GeneIDi1467232.
895387.
919295.
963827.
KEGGicpa:CP0220.
cpj:CPj0532.
cpn:CPn0532.
cpt:CpB0553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18672.1.
AE002161 Genomic DNA. Translation: AAF38089.1.
BA000008 Genomic DNA. Translation: BAA98738.1.
AE009440 Genomic DNA. Translation: AAP98482.1.
PIRiE72066.
H86556.
RefSeqiNP_224728.1. NC_000922.1.
NP_300587.1. NC_002491.1.
NP_444771.1. NC_002179.2.
NP_876825.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9Z820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0532.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18672; AAD18672; CPn_0532.
AAF38089; AAF38089; CP_0220.
AAP98482; AAP98482; CpB0553.
BAA98738; BAA98738; BAA98738.
GeneIDi1467232.
895387.
919295.
963827.
KEGGicpa:CP0220.
cpj:CPj0532.
cpn:CPn0532.
cpt:CpB0553.

Phylogenomic databases

eggNOGiCOG0307.
HOGENOMiHOG000151758.
KOiK00793.
OMAiHILSGHV.
OrthoDBiEOG6VMTQH.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.
BioCyciCPNE115711:GI7B-233-MONOMER.
CPNE115713:GHEY-549-MONOMER.
CPNE138677:GH8N-541-MONOMER.
CPNE182082:GH4N-563-MONOMER.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiIPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiRISA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z820
Secondary accession number(s): Q9JQ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.