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Q9Z7Z3

- SYE_CHLPN

UniProt

Q9Z7Z3 - SYE_CHLPN

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-201-MONOMER.
    CPNE115713:GHEY-579-MONOMER.
    CPNE138677:GH8N-571-MONOMER.
    CPNE182082:GH4N-594-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:CPn_0560, CP_0190, CpB0582
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Glutamate--tRNA ligasePRO_0000119539Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn0560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z7Z3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2211"HIGH" regionAdd
    BLAST
    Motifi253 – 2575"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiWINGYYL.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z7Z3-1 [UniParc]FASTAAdd to Basket

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    MNWENVRVRV APSPTGDPHV GTAYMALFNE IFAKRFKGKM ILRIEDTDRT    50
    RSRQDYEENI FSALRWCGIQ WDEGPDVGGP YGPYRQSERT KIYQGYVETL 100
    LKTDCAYKCF ATPQELAEMR AVASTLGYRG GYDRRYRYLS PEEVASREAA 150
    GQPYTIRLKV PLSGECVFED YSKGRVVFPW ADVDDQVLVK SDGFPTYHFA 200
    NVIDDHLMGI THVLRGEEWL SSTPKHLLLY EAFGWEPPVF LHMPLLLNPD 250
    GTKLSKRKNP TSIFYYRDSG YVKEAFVNFL TLMGYSMEGD EEVYSLERII 300
    ETFNPRRIGK SGAVFDIQKL DWMNKHYLNH EGSPECLLKE LQGWLLNDEF 350
    FLKILPLCQS RITTLAEFIN LTSFFFSGLL EYRVEELLPQ ALSPEKAAIL 400
    LYSYVKYLEK TDQWTKETCY LGSKWLAQAF NVHHKKAIIP LLYVAITGKK 450
    QGLPLFDSIE ILGKPRARAR LVYAEKLLGG VPKKLAATVD KFMQREDFEE 500
    ATFDL 505
    Length:505
    Mass (Da):58,206
    Last modified:May 1, 1999 - v1
    Checksum:i91B580D7C31E6695
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18700.1.
    AE002161 Genomic DNA. Translation: AAF38063.1.
    BA000008 Genomic DNA. Translation: BAA98766.1.
    AE009440 Genomic DNA. Translation: AAP98511.1.
    PIRiC72064.
    D86560.
    RefSeqiNP_224756.1. NC_000922.1.
    NP_300615.1. NC_002491.1.
    NP_444741.1. NC_002179.2.
    NP_876854.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18700; AAD18700; CPn_0560.
    AAF38063; AAF38063; CP_0190.
    AAP98511; AAP98511; CpB0582.
    BAA98766; BAA98766; BAA98766.
    GeneIDi1467261.
    895358.
    919322.
    962974.
    KEGGicpa:CP0190.
    cpj:CPj0560.
    cpn:CPn0560.
    cpt:CpB0582.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18700.1 .
    AE002161 Genomic DNA. Translation: AAF38063.1 .
    BA000008 Genomic DNA. Translation: BAA98766.1 .
    AE009440 Genomic DNA. Translation: AAP98511.1 .
    PIRi C72064.
    D86560.
    RefSeqi NP_224756.1. NC_000922.1.
    NP_300615.1. NC_002491.1.
    NP_444741.1. NC_002179.2.
    NP_876854.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z7Z3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18700 ; AAD18700 ; CPn_0560 .
    AAF38063 ; AAF38063 ; CP_0190 .
    AAP98511 ; AAP98511 ; CpB0582 .
    BAA98766 ; BAA98766 ; BAA98766 .
    GeneIDi 1467261.
    895358.
    919322.
    962974.
    KEGGi cpa:CP0190.
    cpj:CPj0560.
    cpn:CPn0560.
    cpt:CpB0582.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi WINGYYL.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-201-MONOMER.
    CPNE115713:GHEY-579-MONOMER.
    CPNE138677:GH8N-571-MONOMER.
    CPNE182082:GH4N-594-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiSYE_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z7Z3
    Secondary accession number(s): Q9JQI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3