Reviewed, UniProtKB/Swiss-Prot Q9Z7Y6 (CDSA_CHLPN)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	CPn_0567, CP_0182, CpB0589

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Phosphatidate cytidylyltransferase		PRO_0000090732
Regions
	Transmembrane	30 – 50	21	Potential
	Transmembrane	73 – 93	21	Potential
	Transmembrane	100 – 120	21	Potential
	Transmembrane	127 – 147	21	Potential
	Transmembrane	167 – 187	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	235 – 255	21	Potential
	Transmembrane	280 – 300	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7Y6-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: F9B0135EE38D4E67	FASTA	308	34,031
	10 20 30 40 50 60 MLNSNKFKSK TGAYGDLFQR VVVHSLVLTF LVLLLYSSLF PLTSFALGFI TATCGAVGTY 70 80 90 100 110 120 EYSSMAKAKM HYPLSTFSAI GSFLFLALSF LSIRWGHSLP GFFDALPWTL LIVWVVWSIF 130 140 150 160 170 180 RVRKSTIGAL QLSGVTLFSI LYVGIPIRLF LHVLYSFIHT QEPYLGIWWA SFLIATTKGA 190 200 210 220 230 240 DIFGYFFGKA FGNKKIAPQI SPNKTVVGFV AGCLGATLIS FIFFLQIPTR FASYFPMPAI 250 260 270 280 290 300 LIPLGLALGI TGFFGDIIES IFKRDAHLKN SNKLKAVGGM LDTLDSLLLS TPIAYLFLLI TQSKEFIG

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD18707.1. AE002161 Genomic DNA. Translation: AAF38055.1. BA000008 Genomic DNA. Translation: BAA98773.1. AE009440 Genomic DNA. Translation: AAP98518.1.
PIR	C86561. H72062.
RefSeq	NP_224763.1. NP_300622.1. NP_444733.1. NP_876861.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1467268. 895339. 919325. 962984.
GenomeReviews	Gene locus CPn_0567 in contig AE001363_GR. Gene locus CP_0182 in contig AE002161_GR. Gene locus CpB0589 in contig AE009440_GR. Gene locus cdsA in contig BA000008_GR.
KEGG	cpa:CP0182. cpn:CPn0567. cpt:CpB0589.
TIGR	CP_0182.
Phylogenomic databases
HOGENOM	Q9Z7Y6.
OMA	ESIFKRD.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0182-MON. CPNE115713:CPN0567-MON. CPNE138677:CPJ0567-MON. CPNE182082:CPB0589-MON.
BRENDA	2.7.7.41. 264832.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_CHLPN

Accession

Primary (citable) accession number: Q9Z7Y6
Secondary accession number(s): Q9JQ17

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)