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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:CPn_0567, CP_0182, CpB0589
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907321 – 308Phosphatidate cytidylyltransferaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0567.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575. LUCA.
HOGENOMiHOG000034746.
KOiK00981.
OMAiTEYFSWA.
OrthoDBiPOG091H001F.

Sequencei

Sequence statusi: Complete.

Q9Z7Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSNKFKSK TGAYGDLFQR VVVHSLVLTF LVLLLYSSLF PLTSFALGFI
60 70 80 90 100
TATCGAVGTY EYSSMAKAKM HYPLSTFSAI GSFLFLALSF LSIRWGHSLP
110 120 130 140 150
GFFDALPWTL LIVWVVWSIF RVRKSTIGAL QLSGVTLFSI LYVGIPIRLF
160 170 180 190 200
LHVLYSFIHT QEPYLGIWWA SFLIATTKGA DIFGYFFGKA FGNKKIAPQI
210 220 230 240 250
SPNKTVVGFV AGCLGATLIS FIFFLQIPTR FASYFPMPAI LIPLGLALGI
260 270 280 290 300
TGFFGDIIES IFKRDAHLKN SNKLKAVGGM LDTLDSLLLS TPIAYLFLLI

TQSKEFIG
Length:308
Mass (Da):34,031
Last modified:May 1, 1999 - v1
Checksum:iF9B0135EE38D4E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18707.1.
AE002161 Genomic DNA. Translation: AAF38055.1.
BA000008 Genomic DNA. Translation: BAA98773.1.
AE009440 Genomic DNA. Translation: AAP98518.1.
PIRiC86561.
H72062.
RefSeqiNP_224763.1. NC_000922.1.
WP_010883205.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18707; AAD18707; CPn_0567.
AAF38055; AAF38055; CP_0182.
AAP98518; AAP98518; CpB0589.
BAA98773; BAA98773; BAA98773.
GeneIDi895339.
KEGGicpa:CP_0182.
cpj:cdsA.
cpn:CPn0567.
cpt:CpB0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18707.1.
AE002161 Genomic DNA. Translation: AAF38055.1.
BA000008 Genomic DNA. Translation: BAA98773.1.
AE009440 Genomic DNA. Translation: AAP98518.1.
PIRiC86561.
H72062.
RefSeqiNP_224763.1. NC_000922.1.
WP_010883205.1. NZ_LN847257.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18707; AAD18707; CPn_0567.
AAF38055; AAF38055; CP_0182.
AAP98518; AAP98518; CpB0589.
BAA98773; BAA98773; BAA98773.
GeneIDi895339.
KEGGicpa:CP_0182.
cpj:cdsA.
cpn:CPn0567.
cpt:CpB0589.

Phylogenomic databases

eggNOGiCOG0575. LUCA.
HOGENOMiHOG000034746.
KOiK00981.
OMAiTEYFSWA.
OrthoDBiPOG091H001F.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCDSA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7Y6
Secondary accession number(s): Q9JQ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.