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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-193-MONOMER.
CPNE115713:GHEY-586-MONOMER.
CPNE138677:GH8N-578-MONOMER.
CPNE182082:GH4N-601-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:CPn_0567, CP_0182, CpB0589
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000802 Componenti: Chromosome UP000000583 Componenti: Chromosome UP000000801 Componenti: Chromosome UP000000424 Componenti: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Phosphatidate cytidylyltransferasePRO_0000090732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0567.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000034746.
KOiK00981.
OMAiEVFWIST.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSNKFKSK TGAYGDLFQR VVVHSLVLTF LVLLLYSSLF PLTSFALGFI
60 70 80 90 100
TATCGAVGTY EYSSMAKAKM HYPLSTFSAI GSFLFLALSF LSIRWGHSLP
110 120 130 140 150
GFFDALPWTL LIVWVVWSIF RVRKSTIGAL QLSGVTLFSI LYVGIPIRLF
160 170 180 190 200
LHVLYSFIHT QEPYLGIWWA SFLIATTKGA DIFGYFFGKA FGNKKIAPQI
210 220 230 240 250
SPNKTVVGFV AGCLGATLIS FIFFLQIPTR FASYFPMPAI LIPLGLALGI
260 270 280 290 300
TGFFGDIIES IFKRDAHLKN SNKLKAVGGM LDTLDSLLLS TPIAYLFLLI

TQSKEFIG
Length:308
Mass (Da):34,031
Last modified:May 1, 1999 - v1
Checksum:iF9B0135EE38D4E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18707.1.
AE002161 Genomic DNA. Translation: AAF38055.1.
BA000008 Genomic DNA. Translation: BAA98773.1.
AE009440 Genomic DNA. Translation: AAP98518.1.
PIRiC86561.
H72062.
RefSeqiNP_224763.1. NC_000922.1.
NP_300622.1. NC_002491.1.
NP_444733.1. NC_002179.2.
NP_876861.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18707; AAD18707; CPn_0567.
AAF38055; AAF38055; CP_0182.
AAP98518; AAP98518; CpB0589.
BAA98773; BAA98773; BAA98773.
GeneIDi895339.
962984.
KEGGicpa:CP0182.
cpj:CPj0567.
cpn:CPn0567.
cpt:CpB0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18707.1.
AE002161 Genomic DNA. Translation: AAF38055.1.
BA000008 Genomic DNA. Translation: BAA98773.1.
AE009440 Genomic DNA. Translation: AAP98518.1.
PIRiC86561.
H72062.
RefSeqiNP_224763.1. NC_000922.1.
NP_300622.1. NC_002491.1.
NP_444733.1. NC_002179.2.
NP_876861.1. NC_005043.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18707; AAD18707; CPn_0567.
AAF38055; AAF38055; CP_0182.
AAP98518; AAP98518; CpB0589.
BAA98773; BAA98773; BAA98773.
GeneIDi895339.
962984.
KEGGicpa:CP0182.
cpj:CPj0567.
cpn:CPn0567.
cpt:CpB0589.

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000034746.
KOiK00981.
OMAiEVFWIST.
OrthoDBiEOG6TBHJT.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
BioCyciCPNE115711:GI7B-193-MONOMER.
CPNE115713:GHEY-586-MONOMER.
CPNE138677:GH8N-578-MONOMER.
CPNE182082:GH4N-601-MONOMER.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiCDSA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7Y6
Secondary accession number(s): Q9JQ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.