Q9Z7Y5 (KCY_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	CPn_0568, CP_0181, CpB0590

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00238
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Cytidylate kinase HAMAP-Rule MF_00238		PRO_0000131900
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7Y5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 1F0FF97A8116FF0F	FASTA	216	24,080
	10 20 30 40 50 60 MIITIDGPSG TGKSTTAKAL ADHLHFNYCN TGKMYRTLAY ARLQSPWATL PLTKFLEEPP 70 80 90 100 110 120 FSFTFATGQP LESFFNGHLL TSELTTQEVA NAASELSQLP EVRAFMQDLQ RRYAQLGNCV 130 140 150 160 170 180 FEGRDMGSKV FPNADLKIFL TSSPEVRAQR RLKDLPEGTL SPEQLQAELV KRDAADAQRA 190 200 210 HDPLVIPENG IVIDSSDLTI RQVLEKILAL LFRNEL

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18708.1. AE002161 Genomic DNA. Translation: AAF38054.1. BA000008 Genomic DNA. Translation: BAA98774.1. AE009440 Genomic DNA. Translation: AAP98519.1.
PIR	A72063. D86561.
RefSeq	NP_224764.1. NC_000922.1. NP_300623.1. NC_002491.1. NP_444732.1. NC_002179.2. NP_876862.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z7Y5.
ModBase	Search...
Protein-protein interaction databases
STRING	115713.CPn0568.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD18708; AAD18708; CPn_0568. AAF38054; AAF38054; CP_0181. AAP98519; AAP98519; CpB0590. BAA98774; BAA98774; BAA98774.
GeneID	1467269. 895337. 919324. 962966.
KEGG	cpa:CP0181. cpj:CPj0568. cpn:CPn0568. cpt:CpB0590.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
HOGENOM	HOG000242849.
KO	K00945.
OMA	HIDTGAM.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	CPNE115711:GI7B-181-MONOMER. CPNE115713:GHEY-571-MONOMER. CPNE138677:GH8N-560-MONOMER. CPNE182082:GH4N-587-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1.
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_CHLPN

Accession

Primary (citable) accession number: Q9Z7Y5
Secondary accession number(s): Q9JQB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program