Q9Z7V1 (HEMH_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase
EC=4.99.1.1

Alternative name(s):
Heme synthase
Protoheme ferro-lyase

Gene names

Name:	hemH
Ordered Locus Names:	CPn_0603, CP_0144, CpB0627

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.
Sequence caution	The sequence AAP98556.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Ferrochelatase HAMAP MF_00323		PRO_0000175129
Sites
	Metal binding	187	1	Iron By similarity
	Metal binding	265	1	Iron By similarity
Experimental info
	Sequence conflict	254	1	V → A in BAA98810. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7V1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 608A8DC2B2139D44	FASTA	327	37,503
	10 20 30 40 50 60 MTTPAYLLAN FGGPRHAKDL QEFLISLLTD RDVTGTFLPR VLHRHLFTFI AKKRVPKVLP 70 80 90 100 110 120 QYQSLQNWSP IYFDTETLAK TLSEILRAPV IPFHRYLPST HEKTLLALRT LHTRHVIGIP 130 140 150 160 170 180 LFPHFTYSVT GSIVRFFMKH VPEIPISWIP QFGSDSKFVS LITCHIRDFL QKLGILEKEC 190 200 210 220 230 240 CFLFSVHGLP VRYISQGDPY SKQCYESFSA ITTNFKQSEN FLCFQSKFGP GKWLSPSTAQ 250 260 270 280 290 300 LCQNIDTDKP NVIVVPFGFI SDHLETLYEI ERDYLPLLRS RGYRALRIPA IYSSPLWVST 310 320 LVDIVKENST VVAEELIKSG KKHTGIR

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18742.1. AE002161 Genomic DNA. Translation: AAF38026.1. BA000008 Genomic DNA. Translation: BAA98810.1. AE009440 Genomic DNA. Translation: AAP98556.1. Different initiation.
PIR	E72057. H86565.
RefSeq	NP_224799.1. NC_000922.1. NP_300659.1. NC_002491.1. NP_444696.1. NC_002179.2. NP_876899.2. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z7V1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1467306. 895242. 919365. 962792.
GenomeReviews	Gene locus CPn_0603 in contig AE001363_GR. Gene locus CP_0144 in contig AE002161_GR. Gene locus CpB0627 in contig AE009440_GR. Gene locus hemH in contig BA000008_GR.
KEGG	cpa:CP0144. cpn:CPn0603. cpt:CpB0627.
TIGR	CP_0144.
Phylogenomic databases
HOGENOM	HBG697135.
OMA	KPWLGGQ.
ProtClustDB	PRK00035.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0144-MONOMER. CPNE115713:CPN0603-MONOMER. CPNE138677:CPJ0603-MONOMER. CPNE182082:CPB0627-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_CHLPN

Accession

Primary (citable) accession number: Q9Z7V1
Secondary accession number(s): Q9JSD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program