Reviewed, UniProtKB/Swiss-Prot Q9Z7U3 (COAE_CHLPN)

Names and origin

Protein names

Recommended name:
    Dephospho-CoA kinase
    EC=2.7.1.24
Alternative name(s):
    Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	CPn_0611, CP_0136, CpB0635

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity.
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the coaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000172926
Regions
	Domain	6 – 202	197	DPCK
	Nucleotide binding	11 – 18	8	ATP Potential
Experimental info
	Sequence conflict	39	1	H → N in BAA98818. Ref.3
	Sequence conflict	66	1	F → Y in BAA98818. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7U3-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: EE49EE624A68F020	FASTA	202	22,913
	10 20 30 40 50 60 MLKLLKVSIT GDLSSGKTEA CQVFQELGAY VVSADEISHS FLIPHTRIGR RVIDLLGSDV 70 80 90 100 110 120 VVDGAFDAQA IAAKVFYNSV LLQGLEAILH PEVCRIIEEQ YHQSIQDGNY PLFVAEVPLL 130 140 150 160 170 180 YEIHYAKWFD SVILVMANED IRRERFMKKT GRSSEDFDQR CSRFLNVEEK LAQADVVVEN 190 200 NGTKKELHQK IEEYFYALKG AL

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD18750.1. AE002161 Genomic DNA. Translation: AAF38019.1. BA000008 Genomic DNA. Translation: BAA98818.1. AE017159 Genomic DNA. Translation: AAP98564.1. Different initiation.
PIR	E72058. H86566.
RefSeq	NP_224807.1. NP_300667.1. NP_444688.1. NP_876907.1.
3D structure databases
ModBase	Search...
2-D gel databases
PHCI-2DPAGE	Q9Z7U3.
Genome annotation databases
GeneID	1467314. 895469. 919373. 963837.
GenomeReviews	Gene locus CPn_0611 in contig AE001363_GR. Gene locus CP_0136 in contig AE002161_GR. Gene locus CpB0635 in contig AE009440_GR. Gene locus coaE in contig BA000008_GR.
KEGG	cpa:CP0136. cpn:CPn0611. cpt:CpB0635.
TIGR	CP_0136.
Phylogenomic databases
HOGENOM	Q9Z7U3.
OMA	Q9Z7U3. RIIEEQY.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0136-MON. CPNE115713:CPN0611-MON. CPNE138677:CPJ0611-MON. CPNE182082:CPB0635-MON.
BRENDA	2.7.1.24. 264832.
Family and domain databases
HAMAP	MF_00376. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
PANTHER	PTHR10695. Depp_CoAkinase. 1 hit.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
ProDom	PD003329. Depp_CoAkinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00152. Depp_CoAkinase. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_CHLPN

Accession

Primary (citable) accession number: Q9Z7U3
Secondary accession number(s): Q9JSC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)