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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91ATPBy similarity
Binding sitei57 – 571ATPBy similarity
Binding sitei85 – 851ATPBy similarity
Binding sitei91 – 911ATPBy similarity
Binding sitei102 – 1021ATPBy similarity
Binding sitei112 – 1121ATPBy similarity
Active sitei115 – 1151Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-135-MONOMER.
CPNE115713:GHEY-644-MONOMER.
CPNE138677:GH8N-635-MONOMER.
CPNE182082:GH4N-661-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase (EC:2.7.4.6)
Short name:
NDK
Short name:
NDP kinase
Alternative name(s):
Nucleoside-2-P kinase
Gene namesi
Name:ndk
Ordered Locus Names:CPn_0619, CP_0128, CpB0645
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Nucleoside diphosphate kinasePRO_0000136966Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0619.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7T5.
SMRiQ9Z7T5. Positions 1-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224565.
KOiK00940.
OMAiAEHSERP.
OrthoDBiEOG67DPRV.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTLSIIKP DSVSKAHIGE ILSIFEQSGL RIAAMKMMHL SQTEAEGFYF
60 70 80 90 100
VHRERPFFQE LVDFMVSGPV VVLVLEGANA VSRNRELMGA TNPAEAASGT
110 120 130 140
IRAKFGESIG VNAVHGSDTL ENAAVEIAYF FSKIEVVNAS KPLV
Length:144
Mass (Da):15,642
Last modified:May 1, 1999 - v1
Checksum:i6811A3A1FD4C8BBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18758.1.
AE002161 Genomic DNA. Translation: AAF38011.1.
BA000008 Genomic DNA. Translation: BAA98826.1.
AE009440 Genomic DNA. Translation: AAP98574.1.
PIRiG72056.
H86567.
RefSeqiNP_224815.1. NC_000922.1.
WP_010883257.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18758; AAD18758; CPn_0619.
AAF38011; AAF38011; CP_0128.
AAP98574; AAP98574; CpB0645.
BAA98826; BAA98826; BAA98826.
GeneIDi895417.
KEGGicpa:CP_0128.
cpj:ndk.
cpn:CPn0619.
cpt:CpB0645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18758.1.
AE002161 Genomic DNA. Translation: AAF38011.1.
BA000008 Genomic DNA. Translation: BAA98826.1.
AE009440 Genomic DNA. Translation: AAP98574.1.
PIRiG72056.
H86567.
RefSeqiNP_224815.1. NC_000922.1.
WP_010883257.1. NZ_LN847257.1.

3D structure databases

ProteinModelPortaliQ9Z7T5.
SMRiQ9Z7T5. Positions 1-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18758; AAD18758; CPn_0619.
AAF38011; AAF38011; CP_0128.
AAP98574; AAP98574; CpB0645.
BAA98826; BAA98826; BAA98826.
GeneIDi895417.
KEGGicpa:CP_0128.
cpj:ndk.
cpn:CPn0619.
cpt:CpB0645.

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224565.
KOiK00940.
OMAiAEHSERP.
OrthoDBiEOG67DPRV.

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-135-MONOMER.
CPNE115713:GHEY-644-MONOMER.
CPNE138677:GH8N-635-MONOMER.
CPNE182082:GH4N-661-MONOMER.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiNDK_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.