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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPBy similarity1
Binding sitei57ATPBy similarity1
Binding sitei85ATPBy similarity1
Binding sitei91ATPBy similarity1
Binding sitei102ATPBy similarity1
Binding sitei112ATPBy similarity1
Active sitei115Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase (EC:2.7.4.6)
Short name:
NDK
Short name:
NDP kinase
Alternative name(s):
Nucleoside-2-P kinase
Gene namesi
Name:ndk
Ordered Locus Names:CPn_0619, CP_0128, CpB0645
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001369661 – 144Nucleoside diphosphate kinaseAdd BLAST144

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi182082.CpB0645.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7T5.
SMRiQ9Z7T5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224565.
KOiK00940.
OrthoDBiPOG091H040S.

Family and domain databases

Gene3Di3.30.70.141. 2 hits.
HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiView protein in InterPro
IPR034907. NDK-like_dom.
IPR001564. Nucleoside_diP_kinase.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
SUPFAMiSSF54919. SSF54919. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z7T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTLSIIKP DSVSKAHIGE ILSIFEQSGL RIAAMKMMHL SQTEAEGFYF
60 70 80 90 100
VHRERPFFQE LVDFMVSGPV VVLVLEGANA VSRNRELMGA TNPAEAASGT
110 120 130 140
IRAKFGESIG VNAVHGSDTL ENAAVEIAYF FSKIEVVNAS KPLV
Length:144
Mass (Da):15,642
Last modified:May 1, 1999 - v1
Checksum:i6811A3A1FD4C8BBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18758.1.
AE002161 Genomic DNA. Translation: AAF38011.1.
BA000008 Genomic DNA. Translation: BAA98826.1.
AE009440 Genomic DNA. Translation: AAP98574.1.
PIRiG72056.
H86567.
RefSeqiNP_224815.1. NC_000922.1.
WP_010883257.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18758; AAD18758; CPn_0619.
AAF38011; AAF38011; CP_0128.
AAP98574; AAP98574; CpB0645.
BAA98826; BAA98826; BAA98826.
GeneIDi895417.
KEGGicpa:CP_0128.
cpj:ndk.
cpn:CPn0619.
cpt:CpB0645.
PATRICifig|115713.3.peg.689.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNDK_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families