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Q9Z7T3

- RUVC_CHLPN

UniProt

Q9Z7T3 - RUVC_CHLPN

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91MagnesiumBy similarity
    Metal bindingi70 – 701MagnesiumBy similarity
    Metal bindingi145 – 1451MagnesiumBy similarity
    Metal bindingi148 – 1481MagnesiumBy similarity

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-133-MONOMER.
    CPNE115713:GHEY-646-MONOMER.
    CPNE138677:GH8N-637-MONOMER.
    CPNE182082:GH4N-663-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
    Alternative name(s):
    Holliday junction nuclease RuvC
    Holliday junction resolvase RuvC
    Gene namesi
    Name:ruvC
    Ordered Locus Names:CPn_0621, CP_0126, CpB0647
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Crossover junction endodeoxyribonuclease RuvCPRO_0000183088Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0621.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z7T3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.Curated

    Phylogenomic databases

    eggNOGiCOG0817.
    HOGENOMiHOG000012181.
    KOiK01159.
    OMAiRQVQEMV.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.
    TIGRFAMsiTIGR00228. ruvC. 1 hit.
    PROSITEiPS01321. RUVC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z7T3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELIIGVDP GTIVAGYAII AVEQRYQLRP YSYGAIRLSS DMPLPMRYKT    50
    LFEQLSGVLD DTQPNAMVLE TQFVNKNPQS TMKLAMARGI VLLAAAQRDI 100
    LIFEYAPNVA KKAVVGKGHA SKRQVQVMVS KILNVPEVLH PSNEDIADAF 150
    ALAICHTHVA RSPLCGVR 168
    Length:168
    Mass (Da):18,404
    Last modified:May 1, 1999 - v1
    Checksum:i3845FAC6DC0AFD1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18760.1.
    AE002161 Genomic DNA. Translation: AAF38009.1.
    BA000008 Genomic DNA. Translation: BAA98828.1.
    AE009440 Genomic DNA. Translation: AAP98576.1.
    PIRiA72057.
    B86568.
    RefSeqiNP_224817.1. NC_000922.1.
    NP_300677.1. NC_002491.1.
    NP_444678.1. NC_002179.2.
    NP_876919.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18760; AAD18760; CPn_0621.
    AAF38009; AAF38009; CP_0126.
    AAP98576; AAP98576; CpB0647.
    BAA98828; BAA98828; BAA98828.
    GeneIDi1467326.
    895409.
    919385.
    963017.
    KEGGicpa:CP0126.
    cpj:CPj0621.
    cpn:CPn0621.
    cpt:CpB0647.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18760.1 .
    AE002161 Genomic DNA. Translation: AAF38009.1 .
    BA000008 Genomic DNA. Translation: BAA98828.1 .
    AE009440 Genomic DNA. Translation: AAP98576.1 .
    PIRi A72057.
    B86568.
    RefSeqi NP_224817.1. NC_000922.1.
    NP_300677.1. NC_002491.1.
    NP_444678.1. NC_002179.2.
    NP_876919.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z7T3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18760 ; AAD18760 ; CPn_0621 .
    AAF38009 ; AAF38009 ; CP_0126 .
    AAP98576 ; AAP98576 ; CpB0647 .
    BAA98828 ; BAA98828 ; BAA98828 .
    GeneIDi 1467326.
    895409.
    919385.
    963017.
    KEGGi cpa:CP0126.
    cpj:CPj0621.
    cpn:CPn0621.
    cpt:CpB0647.

    Phylogenomic databases

    eggNOGi COG0817.
    HOGENOMi HOG000012181.
    KOi K01159.
    OMAi RQVQEMV.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-133-MONOMER.
    CPNE115713:GHEY-646-MONOMER.
    CPNE138677:GH8N-637-MONOMER.
    CPNE182082:GH4N-663-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    TIGRFAMsi TIGR00228. ruvC. 1 hit.
    PROSITEi PS01321. RUVC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiRUVC_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z7T3
    Secondary accession number(s): Q9JQH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3