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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:CPn_0629, CP_0118, CpB0655
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei162 – 182HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei287 – 307HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Transmembranei386 – 406HelicalUniRule annotationAdd BLAST21
Transmembranei412 – 432HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317181 – 457Protein translocase subunit SecYAdd BLAST457

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0655

Structurei

3D structure databases

ProteinModelPortaliQ9Z7S5
SMRiQ9Z7S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG Bacteria
COG0201 LUCA
HOGENOMiHOG000080585
KOiK03076
OMAiQTYVISQ
OrthoDBiPOG091H024M

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z7S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLRQFFLI TELRQKLFYT FALLTACRVG VFIPVPGING ELAVAYFKQL
60 70 80 90 100
LGSGQNLFQL ADIFSGGAFA QMTVIALGVV PYISASIIVQ LFLVFMPALQ
110 120 130 140 150
REMRESSDQG KRRIGRLTRL FTVALAVIQS LLFAKFALRM NLTIPGIVLP
160 170 180 190 200
TLLSSKLFGV PWIFYITTVV VMTTGTLLLM WIGEQISDKG IGNGISLIIA
210 220 230 240 250
LGILSSFPSV LGSIVNKLNL GSQDSSDLGL ISILILALVF VFVLITTILI
260 270 280 290 300
IEGVRKIPVQ YARRVIGRRE VPGGGSYLPL KVNYAGVIPV IFASSLLMFP
310 320 330 340 350
ATIGQFIASE SSWMKRIAAL LAPGSLVYSI CYVLLIIFFT YFWTATQFHP
360 370 380 390 400
EQIASEMKKN NAFIPGIRQG KPTQHYLEYT MNRVTLLGAL FLAAIAILPS
410 420 430 440 450
LLGCLLRVDS NVSYFLGGTA MLIVVGVVLD TMKQVDAFLL MRRYDSVLKT

DRTKGRH
Length:457
Mass (Da):50,286
Last modified:May 1, 1999 - v1
Checksum:iA3B044E8163EC4C9
GO

Sequence cautioni

The sequence AAF38001 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18768.1
AE002161 Genomic DNA Translation: AAF38001.1 Different initiation.
BA000008 Genomic DNA Translation: BAA98836.1
AE009440 Genomic DNA Translation: AAP98584.1
PIRiB81613
B86569
G72053
RefSeqiNP_224825.1, NC_000922.1
WP_010883267.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18768; AAD18768; CPn_0629
AAF38001; AAF38001; CP_0118
AAP98584; AAP98584; CpB0655
BAA98836; BAA98836; BAA98836
GeneIDi895464
KEGGicpa:CP_0118
cpj:secY
cpn:CPn0629
cpt:CpB0655
PATRICifig|115713.3.peg.699

Similar proteinsi

Entry informationi

Entry nameiSECY_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7S5
Secondary accession number(s): Q9JQH3, Q9K2D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health