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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:CPn_0629, CP_0118, CpB0655
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei162 – 182HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei287 – 307HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Transmembranei386 – 406HelicalUniRule annotationAdd BLAST21
Transmembranei412 – 432HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317181 – 457Protein translocase subunit SecYAdd BLAST457

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0629.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLRQFFLI TELRQKLFYT FALLTACRVG VFIPVPGING ELAVAYFKQL
60 70 80 90 100
LGSGQNLFQL ADIFSGGAFA QMTVIALGVV PYISASIIVQ LFLVFMPALQ
110 120 130 140 150
REMRESSDQG KRRIGRLTRL FTVALAVIQS LLFAKFALRM NLTIPGIVLP
160 170 180 190 200
TLLSSKLFGV PWIFYITTVV VMTTGTLLLM WIGEQISDKG IGNGISLIIA
210 220 230 240 250
LGILSSFPSV LGSIVNKLNL GSQDSSDLGL ISILILALVF VFVLITTILI
260 270 280 290 300
IEGVRKIPVQ YARRVIGRRE VPGGGSYLPL KVNYAGVIPV IFASSLLMFP
310 320 330 340 350
ATIGQFIASE SSWMKRIAAL LAPGSLVYSI CYVLLIIFFT YFWTATQFHP
360 370 380 390 400
EQIASEMKKN NAFIPGIRQG KPTQHYLEYT MNRVTLLGAL FLAAIAILPS
410 420 430 440 450
LLGCLLRVDS NVSYFLGGTA MLIVVGVVLD TMKQVDAFLL MRRYDSVLKT

DRTKGRH
Length:457
Mass (Da):50,286
Last modified:May 1, 1999 - v1
Checksum:iA3B044E8163EC4C9
GO

Sequence cautioni

The sequence AAF38001 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18768.1.
AE002161 Genomic DNA. Translation: AAF38001.1. Different initiation.
BA000008 Genomic DNA. Translation: BAA98836.1.
AE009440 Genomic DNA. Translation: AAP98584.1.
PIRiB81613.
B86569.
G72053.
RefSeqiNP_224825.1. NC_000922.1.
WP_010883267.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18768; AAD18768; CPn_0629.
AAF38001; AAF38001; CP_0118.
AAP98584; AAP98584; CpB0655.
BAA98836; BAA98836; BAA98836.
GeneIDi895464.
KEGGicpa:CP_0118.
cpj:secY.
cpn:CPn0629.
cpt:CpB0655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18768.1.
AE002161 Genomic DNA. Translation: AAF38001.1. Different initiation.
BA000008 Genomic DNA. Translation: BAA98836.1.
AE009440 Genomic DNA. Translation: AAP98584.1.
PIRiB81613.
B86569.
G72053.
RefSeqiNP_224825.1. NC_000922.1.
WP_010883267.1. NZ_LN847257.1.

3D structure databases

ProteinModelPortaliQ9Z7S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18768; AAD18768; CPn_0629.
AAF38001; AAF38001; CP_0118.
AAP98584; AAP98584; CpB0655.
BAA98836; BAA98836; BAA98836.
GeneIDi895464.
KEGGicpa:CP_0118.
cpj:secY.
cpn:CPn0629.
cpt:CpB0655.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7S5
Secondary accession number(s): Q9JQH3, Q9K2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.