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Q9Z7Q4

- LPXA_CHLPN

UniProt

Q9Z7Q4 - LPXA_CHLPN

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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene
lpxA, CPn_0650, CP_0097, CpB0676
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-103-MONOMER.
CPNE115713:GHEY-676-MONOMER.
CPNE138677:GH8N-667-MONOMER.
CPNE182082:GH4N-693-MONOMER.
UniPathwayiUPA00359; UER00477.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (EC:2.3.1.129)
Short name:
UDP-N-acetylglucosamine acyltransferase
Gene namesi
Name:lpxA
Ordered Locus Names:CPn_0650, CP_0097, CpB0676
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotationPRO_0000188042Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0650.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7Q4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1043.
HOGENOMiHOG000294326.
KOiK00677.
OMAiIMTSAHI.
OrthoDBiEOG6F81P1.

Family and domain databases

Gene3Di1.20.1180.10. 1 hit.
HAMAPiMF_00387. LpxA.
InterProiIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 4 hits.
[Graphical view]
PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7Q4-1 [UniParc]FASTAAdd to Basket

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MASIHPTAII EPGAKIGKDV VIEPYVVIKA TVTLCDNVVV KSYAYIDGNT    50
TIGKGTTIWP SAMIGNKPQD LKYQGEKTYV TIGENCEIRE FAIITSSTFE 100
GTTVSIGNNC LIMPWAHVAH NCTIGNNVVL SNHAQLAGHV QVGDYAILGG 150
MVGVHQFVRI GAHAMVGALS GIRRDVPPYT IGSGNPYQLA GINKVGLQRR 200
QVPFATRLAL IKAFKKIYRA DGCFFESLEE TLEEYGDIPE VKNFIEFCQS 250
PSKRGIERSI DKQALEEESA DKEGVLIES 279
Length:279
Mass (Da):30,345
Last modified:May 1, 1999 - v1
Checksum:i58A0EBB8BE9F488A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18789.1.
AE002161 Genomic DNA. Translation: AAF37981.1.
BA000008 Genomic DNA. Translation: BAA98857.1.
AE009440 Genomic DNA. Translation: AAP98605.1.
PIRiC72051.
G86571.
RefSeqiNP_224846.1. NC_000922.1.
NP_300706.1. NC_002491.1.
NP_444649.1. NC_002179.2.
NP_876948.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18789; AAD18789; CPn_0650.
AAF37981; AAF37981; CP_0097.
AAP98605; AAP98605; CpB0676.
BAA98857; BAA98857; BAA98857.
GeneIDi1467355.
895282.
919411.
963035.
KEGGicpa:CP0097.
cpj:CPj0650.
cpn:CPn0650.
cpt:CpB0676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18789.1 .
AE002161 Genomic DNA. Translation: AAF37981.1 .
BA000008 Genomic DNA. Translation: BAA98857.1 .
AE009440 Genomic DNA. Translation: AAP98605.1 .
PIRi C72051.
G86571.
RefSeqi NP_224846.1. NC_000922.1.
NP_300706.1. NC_002491.1.
NP_444649.1. NC_002179.2.
NP_876948.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z7Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18789 ; AAD18789 ; CPn_0650 .
AAF37981 ; AAF37981 ; CP_0097 .
AAP98605 ; AAP98605 ; CpB0676 .
BAA98857 ; BAA98857 ; BAA98857 .
GeneIDi 1467355.
895282.
919411.
963035.
KEGGi cpa:CP0097.
cpj:CPj0650.
cpn:CPn0650.
cpt:CpB0676.

Phylogenomic databases

eggNOGi COG1043.
HOGENOMi HOG000294326.
KOi K00677.
OMAi IMTSAHI.
OrthoDBi EOG6F81P1.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00477 .
BioCyci CPNE115711:GI7B-103-MONOMER.
CPNE115713:GHEY-676-MONOMER.
CPNE138677:GH8N-667-MONOMER.
CPNE182082:GH4N-693-MONOMER.

Family and domain databases

Gene3Di 1.20.1180.10. 1 hit.
HAMAPi MF_00387. LpxA.
InterProi IPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 4 hits.
[Graphical view ]
PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiLPXA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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