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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC), UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC), UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK), Tetraacyldisaccharide 4'-kinase (lpxK), Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00477

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotation
Ordered Locus Names:CPn_0650, CP_0097, CpB0676
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001880421 – 279Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseAdd BLAST279

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0676

Structurei

3D structure databases

ProteinModelPortaliQ9Z7Q4
SMRiQ9Z7Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DAF Bacteria
COG1043 LUCA
HOGENOMiHOG000294326
KOiK00677
OMAiRECVTIN
OrthoDBiPOG091H022E

Family and domain databases

CDDicd03351 LbH_UDP-GlcNAc_AT, 1 hit
Gene3Di1.20.1180.10, 1 hit
HAMAPiMF_00387 LpxA, 1 hit
InterProiView protein in InterPro
IPR029098 Acetyltransf_C
IPR037157 Acetyltransf_C_sf
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR010137 Lipid_A_LpxA
IPR011004 Trimer_LpxA-like_sf
PANTHERiPTHR43480 PTHR43480, 1 hit
PfamiView protein in Pfam
PF13720 Acetyltransf_11, 1 hit
PF00132 Hexapep, 3 hits
PIRSFiPIRSF000456 UDP-GlcNAc_acltr, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01852 lipid_A_lpxA, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 2 hits

Sequencei

Sequence statusi: Complete.

Q9Z7Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIHPTAII EPGAKIGKDV VIEPYVVIKA TVTLCDNVVV KSYAYIDGNT
60 70 80 90 100
TIGKGTTIWP SAMIGNKPQD LKYQGEKTYV TIGENCEIRE FAIITSSTFE
110 120 130 140 150
GTTVSIGNNC LIMPWAHVAH NCTIGNNVVL SNHAQLAGHV QVGDYAILGG
160 170 180 190 200
MVGVHQFVRI GAHAMVGALS GIRRDVPPYT IGSGNPYQLA GINKVGLQRR
210 220 230 240 250
QVPFATRLAL IKAFKKIYRA DGCFFESLEE TLEEYGDIPE VKNFIEFCQS
260 270
PSKRGIERSI DKQALEEESA DKEGVLIES
Length:279
Mass (Da):30,345
Last modified:May 1, 1999 - v1
Checksum:i58A0EBB8BE9F488A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18789.1
AE002161 Genomic DNA Translation: AAF37981.1
BA000008 Genomic DNA Translation: BAA98857.1
AE009440 Genomic DNA Translation: AAP98605.1
PIRiC72051
G86571
RefSeqiNP_224846.1, NC_000922.1
WP_010883288.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18789; AAD18789; CPn_0650
AAF37981; AAF37981; CP_0097
AAP98605; AAP98605; CpB0676
BAA98857; BAA98857; BAA98857
GeneIDi895282
KEGGicpa:CP_0097
cpj:lpxA
cpn:CPn0650
cpt:CpB0676
PATRICifig|115713.3.peg.720

Similar proteinsi

Entry informationi

Entry nameiLPXA_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health