Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei154 – 1541SubstrateBy similarity
Binding sitei207 – 2071ATPBy similarity
Binding sitei298 – 2981ATP; via carbonyl oxygenBy similarity
Binding sitei329 – 3291ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi356 – 3594ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-73-MONOMER.
CPNE115713:GHEY-706-MONOMER.
CPNE138677:GH8N-697-MONOMER.
CPNE182082:GH4N-724-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:CPn_0679, CP_0068, CpB0706
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000583 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Phosphoglycerate kinasePRO_0000145927Add
BLAST

Proteomic databases

PRIDEiQ9Z7M5.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0679.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni59 – 624Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLTVQDLS PEEKKVLVRV DFNVPMQDGK ILDDIRIRSA MPTINYLLKK
60 70 80 90 100
HAAVILMSHL GRPKGQGFQE EYSLQPVVDV LEGYLGHHVP LAPDCVGEVA
110 120 130 140 150
RQAVAQLSPG RVLLLENLRF HIGEEHPEKD PTFAAELSSY GDFYVNDAFG
160 170 180 190 200
TSHRKHASVY VVPQAFPGRA AAGLLMEKEL EFLGRHLLTS PKRPFTAILG
210 220 230 240 250
GAKISSKIGV IEALLNQVDY LLLAGGMGFT FLQALGKSLG NSLVEKSALD
260 270 280 290 300
LARNVLKIAK SRNVTIVLPS DVKAAENLQS KEYSVISIDQ GIPPHLQGFD
310 320 330 340 350
IGPRTTEEFI RIINQSATVF WNGPVGVYEV PPFDSGSIAI ANALGNHPSA
360 370 380 390 400
VTVVGGGDAA AVVALAGCST KVSHVSTGGG ASLEFLEQGF LPGTEVLSPS

KS
Length:402
Mass (Da):43,046
Last modified:May 1, 1999 - v1
Checksum:i14720238499ECF28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18818.1.
AE002161 Genomic DNA. Translation: AAF37956.1.
BA000008 Genomic DNA. Translation: BAA98886.1.
AE009440 Genomic DNA. Translation: AAP98635.1.
PIRiC72049.
D86575.
RefSeqiNP_224875.1. NC_000922.1.

Genome annotation databases

EnsemblBacteriaiAAD18818; AAD18818; CPn_0679.
AAF37956; AAF37956; CP_0068.
AAP98635; AAP98635; CpB0706.
BAA98886; BAA98886; BAA98886.
GeneIDi895421.
KEGGicpa:CP0068.
cpj:CPj0679.
cpn:CPn0679.
cpt:CpB0706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18818.1.
AE002161 Genomic DNA. Translation: AAF37956.1.
BA000008 Genomic DNA. Translation: BAA98886.1.
AE009440 Genomic DNA. Translation: AAP98635.1.
PIRiC72049.
D86575.
RefSeqiNP_224875.1. NC_000922.1.

3D structure databases

ProteinModelPortaliQ9Z7M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0679.

Proteomic databases

PRIDEiQ9Z7M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18818; AAD18818; CPn_0679.
AAF37956; AAF37956; CP_0068.
AAP98635; AAP98635; CpB0706.
BAA98886; BAA98886; BAA98886.
GeneIDi895421.
KEGGicpa:CP0068.
cpj:CPj0679.
cpn:CPn0679.
cpt:CpB0706.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciCPNE115711:GI7B-73-MONOMER.
CPNE115713:GHEY-706-MONOMER.
CPNE138677:GH8N-697-MONOMER.
CPNE182082:GH4N-724-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiPGK_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7M5
Secondary accession number(s): Q9JQF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.