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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno)
  5. Pyruvate kinase (pyk), Pyruvate kinase (pyk), Pyruvate kinase (pyk), Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei207ATPBy similarity1
Binding sitei298ATP; via carbonyl oxygenBy similarity1
Binding sitei329ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 359ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:CPn_0679, CP_0068, CpB0706
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459271 – 402Phosphoglycerate kinaseAdd BLAST402

Proteomic databases

PRIDEiQ9Z7M5

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi182082.CpB0706

Structurei

3D structure databases

ProteinModelPortaliQ9Z7M5
SMRiQ9Z7M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingBy similarity3
Regioni59 – 62Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z7M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLTVQDLS PEEKKVLVRV DFNVPMQDGK ILDDIRIRSA MPTINYLLKK
60 70 80 90 100
HAAVILMSHL GRPKGQGFQE EYSLQPVVDV LEGYLGHHVP LAPDCVGEVA
110 120 130 140 150
RQAVAQLSPG RVLLLENLRF HIGEEHPEKD PTFAAELSSY GDFYVNDAFG
160 170 180 190 200
TSHRKHASVY VVPQAFPGRA AAGLLMEKEL EFLGRHLLTS PKRPFTAILG
210 220 230 240 250
GAKISSKIGV IEALLNQVDY LLLAGGMGFT FLQALGKSLG NSLVEKSALD
260 270 280 290 300
LARNVLKIAK SRNVTIVLPS DVKAAENLQS KEYSVISIDQ GIPPHLQGFD
310 320 330 340 350
IGPRTTEEFI RIINQSATVF WNGPVGVYEV PPFDSGSIAI ANALGNHPSA
360 370 380 390 400
VTVVGGGDAA AVVALAGCST KVSHVSTGGG ASLEFLEQGF LPGTEVLSPS

KS
Length:402
Mass (Da):43,046
Last modified:May 1, 1999 - v1
Checksum:i14720238499ECF28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18818.1
AE002161 Genomic DNA Translation: AAF37956.1
BA000008 Genomic DNA Translation: BAA98886.1
AE009440 Genomic DNA Translation: AAP98635.1
PIRiC72049
D86575
RefSeqiNP_224875.1, NC_000922.1
WP_010883317.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18818; AAD18818; CPn_0679
AAF37956; AAF37956; CP_0068
AAP98635; AAP98635; CpB0706
BAA98886; BAA98886; BAA98886
GeneIDi895421
KEGGicpa:CP_0068
cpj:pgk
cpn:CPn0679
cpt:CpB0706
PATRICifig|115713.3.peg.750

Similar proteinsi

Entry informationi

Entry nameiPGK_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7M5
Secondary accession number(s): Q9JQF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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