Reviewed, UniProtKB/Swiss-Prot Q9Z7H0 (URK_CHLPN)

Names and origin

Protein names

Recommended name:
    Uridine kinase
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase
    Cytidine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	CPn_0735, CP_0011, CPj0735, CpB0763

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine salvage Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Uridine kinase HAMAP MF_00551		PRO_0000164466
Regions
	Nucleotide binding	13 – 20	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7H0-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B13012BDCC8A2708	FASTA	222	25,758
	10 20 30 40 50 60 MLMMLMMIIG ITGGSGAGKT TLTQNIKEIF GEDVSVICQD NYYKDRSHYT PEERANLIWD 70 80 90 100 110 120 HPDAFDNDLL ISDIKRLKNN EIVQAPVFDF VLGNRSKTEI ETIYPSKVIL VEGILVFENQ 130 140 150 160 170 180 ELRDLMDIRI FVDTDADERI LRRMVRDVQE QGDSVDCIMS RYLSMVKPMH EKFIEPTRKY 190 200 210 220 ADIIVHGNYR QNVVTNILSQ KIKNHLENAL ESDETYYMVN SK

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD18874.1. AE002161 Genomic DNA. Translation: AAF37907.1. BA000008 Genomic DNA. Translation: BAA98942.1. AE017159 Genomic DNA. Translation: AAP98692.1.
PIR	D86582. E72041.
RefSeq	NP_224931.1. NP_300791.1. NP_444563.1. NP_877035.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1467442. 894758. 919506. 963633.
GenomeReviews	Gene locus CPn_0735 in contig AE001363_GR. Gene locus CP_0011 in contig AE002161_GR. Gene locus CpB0763 in contig AE009440_GR. Gene locus CPj0735 in contig BA000008_GR.
KEGG	cpa:CP0011. cpj:CPj0735. cpn:CPn0735. cpt:CpB0763.
TIGR	CP_0011.
Phylogenomic databases
HOGENOM	Q9Z7H0.
OMA	Q9Z7H0. NQFIEPT.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0011-MON. CPNE115713:CPN0735-MON. CPNE138677:CPJ0735-MON. CPNE182082:CPB0763-MON.
BRENDA	2.7.1.48. 264832.
Family and domain databases
HAMAP	MF_00551. [Tree]
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_CHLPN

Accession

Primary (citable) accession number: Q9Z7H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)