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Q9Z7G1

- HEM2_CHLPN

UniProt

Q9Z7G1 - HEM2_CHLPN

Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.By similarity

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei199 – 1991Schiff-base intermediate with substrateBy similarity
    Binding sitei209 – 2091Substrate 1By similarity
    Binding sitei221 – 2211Substrate 1By similarity
    Metal bindingi237 – 2371MagnesiumBy similarity
    Active sitei252 – 2521Schiff-base intermediate with substrateBy similarity
    Binding sitei278 – 2781Substrate 2By similarity
    Binding sitei317 – 3171Substrate 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-1-MONOMER.
    CPNE115713:GHEY-777-MONOMER.
    CPNE138677:GH8N-768-MONOMER.
    CPNE182082:GH4N-796-MONOMER.
    UniPathwayiUPA00251; UER00318.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
    Short name:
    ALAD
    Short name:
    ALADH
    Alternative name(s):
    Porphobilinogen synthase
    Gene namesi
    Name:hemB
    Ordered Locus Names:CPn_0744, CP_0001, CpB0772
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Delta-aminolevulinic acid dehydratasePRO_0000140496Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi115713.CPn0744.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z7G1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.Curated

    Phylogenomic databases

    eggNOGiCOG0113.
    HOGENOMiHOG000020323.
    KOiK01698.
    OMAiMTILTHR.
    OrthoDBiEOG6VXFCB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z7G1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLTLSRRP RRNRKTAAIR DLLAETHLSP KDLIAPFFVK YGNNIKEEIP    50
    SLPGVFRWSL DLLLKEIERL CTYGLRAVML FPIIPDDLKD AYGSYSSNPK 100
    NILCHSIHEI KNAFPHLCLI SDIALDPYTT HGHDGIFLNG EVLNDESVRI 150
    FGNIATLHAE MGADIVAPSD MMDGRIGYIR SKLDQSGYSK TSIMSYSVKY 200
    ASCLYSPFRD ALSSHVTSGD KKQYQMNPKN VLEALLESSL DEEEGADILM 250
    VKPAGLYLDV IYRIRQNTCL PLAAYQVSGE YAMILSAFQQ GWLDKETLFH 300
    ESLIAIKRAG ADMIISYSAP FILELLHQGF EF 332
    Length:332
    Mass (Da):37,280
    Last modified:May 1, 1999 - v1
    Checksum:iC29BABFE31114F6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18883.1.
    AE002161 Genomic DNA. Translation: AAF37898.1.
    BA000008 Genomic DNA. Translation: BAA98951.1.
    AE009440 Genomic DNA. Translation: AAP98701.1.
    PIRiE86583.
    F72040.
    RefSeqiNP_224940.1. NC_000922.1.
    NP_300800.1. NC_002491.1.
    NP_444554.1. NC_002179.2.
    NP_877044.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18883; AAD18883; CPn_0744.
    AAF37898; AAF37898; CP_0001.
    AAP98701; AAP98701; CpB0772.
    BAA98951; BAA98951; BAA98951.
    GeneIDi1467451.
    895528.
    919514.
    963624.
    KEGGicpa:CP0001.
    cpj:CPj0744.
    cpn:CPn0744.
    cpt:CpB0772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18883.1 .
    AE002161 Genomic DNA. Translation: AAF37898.1 .
    BA000008 Genomic DNA. Translation: BAA98951.1 .
    AE009440 Genomic DNA. Translation: AAP98701.1 .
    PIRi E86583.
    F72040.
    RefSeqi NP_224940.1. NC_000922.1.
    NP_300800.1. NC_002491.1.
    NP_444554.1. NC_002179.2.
    NP_877044.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z7G1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0744.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18883 ; AAD18883 ; CPn_0744 .
    AAF37898 ; AAF37898 ; CP_0001 .
    AAP98701 ; AAP98701 ; CpB0772 .
    BAA98951 ; BAA98951 ; BAA98951 .
    GeneIDi 1467451.
    895528.
    919514.
    963624.
    KEGGi cpa:CP0001.
    cpj:CPj0744.
    cpn:CPn0744.
    cpt:CpB0772.

    Phylogenomic databases

    eggNOGi COG0113.
    HOGENOMi HOG000020323.
    KOi K01698.
    OMAi MTILTHR.
    OrthoDBi EOG6VXFCB.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00318 .
    BioCyci CPNE115711:GI7B-1-MONOMER.
    CPNE115713:GHEY-777-MONOMER.
    CPNE138677:GH8N-768-MONOMER.
    CPNE182082:GH4N-796-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiHEM2_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z7G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3