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Q9Z7G1

- HEM2_CHLPN

UniProt

Q9Z7G1 - HEM2_CHLPN

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Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).By similarity

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Schiff-base intermediate with substrateBy similarity
Binding sitei209 – 2091Substrate 1By similarity
Binding sitei221 – 2211Substrate 1By similarity
Metal bindingi237 – 2371MagnesiumBy similarity
Active sitei252 – 2521Schiff-base intermediate with substrateBy similarity
Binding sitei278 – 2781Substrate 2By similarity
Binding sitei317 – 3171Substrate 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-1-MONOMER.
CPNE115713:GHEY-777-MONOMER.
CPNE138677:GH8N-768-MONOMER.
CPNE182082:GH4N-796-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:CPn_0744, CP_0001, CpB0772
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Delta-aminolevulinic acid dehydratasePRO_0000140496Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0744.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.Curated

Phylogenomic databases

eggNOGiCOG0113.
HOGENOMiHOG000020323.
KOiK01698.
OMAiMTILTHR.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLTLSRRP RRNRKTAAIR DLLAETHLSP KDLIAPFFVK YGNNIKEEIP
60 70 80 90 100
SLPGVFRWSL DLLLKEIERL CTYGLRAVML FPIIPDDLKD AYGSYSSNPK
110 120 130 140 150
NILCHSIHEI KNAFPHLCLI SDIALDPYTT HGHDGIFLNG EVLNDESVRI
160 170 180 190 200
FGNIATLHAE MGADIVAPSD MMDGRIGYIR SKLDQSGYSK TSIMSYSVKY
210 220 230 240 250
ASCLYSPFRD ALSSHVTSGD KKQYQMNPKN VLEALLESSL DEEEGADILM
260 270 280 290 300
VKPAGLYLDV IYRIRQNTCL PLAAYQVSGE YAMILSAFQQ GWLDKETLFH
310 320 330
ESLIAIKRAG ADMIISYSAP FILELLHQGF EF
Length:332
Mass (Da):37,280
Last modified:May 1, 1999 - v1
Checksum:iC29BABFE31114F6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18883.1.
AE002161 Genomic DNA. Translation: AAF37898.1.
BA000008 Genomic DNA. Translation: BAA98951.1.
AE009440 Genomic DNA. Translation: AAP98701.1.
PIRiE86583.
F72040.
RefSeqiNP_224940.1. NC_000922.1.
NP_300800.1. NC_002491.1.
NP_444554.1. NC_002179.2.
NP_877044.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18883; AAD18883; CPn_0744.
AAF37898; AAF37898; CP_0001.
AAP98701; AAP98701; CpB0772.
BAA98951; BAA98951; BAA98951.
GeneIDi1467451.
895528.
919514.
963624.
KEGGicpa:CP0001.
cpj:CPj0744.
cpn:CPn0744.
cpt:CpB0772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18883.1 .
AE002161 Genomic DNA. Translation: AAF37898.1 .
BA000008 Genomic DNA. Translation: BAA98951.1 .
AE009440 Genomic DNA. Translation: AAP98701.1 .
PIRi E86583.
F72040.
RefSeqi NP_224940.1. NC_000922.1.
NP_300800.1. NC_002491.1.
NP_444554.1. NC_002179.2.
NP_877044.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z7G1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18883 ; AAD18883 ; CPn_0744 .
AAF37898 ; AAF37898 ; CP_0001 .
AAP98701 ; AAP98701 ; CpB0772 .
BAA98951 ; BAA98951 ; BAA98951 .
GeneIDi 1467451.
895528.
919514.
963624.
KEGGi cpa:CP0001.
cpj:CPj0744.
cpn:CPn0744.
cpt:CpB0772.

Phylogenomic databases

eggNOGi COG0113.
HOGENOMi HOG000020323.
KOi K01698.
OMAi MTILTHR.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci CPNE115711:GI7B-1-MONOMER.
CPNE115713:GHEY-777-MONOMER.
CPNE138677:GH8N-768-MONOMER.
CPNE182082:GH4N-796-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiHEM2_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3