Reviewed, UniProtKB/Swiss-Prot Q9Z7G1 (HEM2_CHLPN)

Names and origin

Protein names

Recommended name:
    Delta-aminolevulinic acid dehydratase
      Short name=ALADH
      Short name=ALAD
    EC=4.2.1.24
Alternative name(s):
    Porphobilinogen synthase

Gene names

Name:	hemB
Ordered Locus Names:	CPn_0744, CP_0001, CpB0772

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the ALADH family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Delta-aminolevulinic acid dehydratase		PRO_0000140496
Sites
	Active site	252	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7G1-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C29BABFE31114F6E	FASTA	332	37,280
	10 20 30 40 50 60 MSSLTLSRRP RRNRKTAAIR DLLAETHLSP KDLIAPFFVK YGNNIKEEIP SLPGVFRWSL 70 80 90 100 110 120 DLLLKEIERL CTYGLRAVML FPIIPDDLKD AYGSYSSNPK NILCHSIHEI KNAFPHLCLI 130 140 150 160 170 180 SDIALDPYTT HGHDGIFLNG EVLNDESVRI FGNIATLHAE MGADIVAPSD MMDGRIGYIR 190 200 210 220 230 240 SKLDQSGYSK TSIMSYSVKY ASCLYSPFRD ALSSHVTSGD KKQYQMNPKN VLEALLESSL 250 260 270 280 290 300 DEEEGADILM VKPAGLYLDV IYRIRQNTCL PLAAYQVSGE YAMILSAFQQ GWLDKETLFH 310 320 330 ESLIAIKRAG ADMIISYSAP FILELLHQGF EF

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD18883.1. AE002161 Genomic DNA. Translation: AAF37898.1. BA000008 Genomic DNA. Translation: BAA98951.1. AE009440 Genomic DNA. Translation: AAP98701.1.
PIR	E86583. F72040.
RefSeq	NP_224940.1. NP_300800.1. NP_444554.1. NP_877044.1.
3D structure databases
HSSP	HSSP built from PDB template 1B4K based on UniProtKB Q59643.
ModBase	Search...
Genome annotation databases
GeneID	1467451. 895528. 919514. 963624.
GenomeReviews	Gene locus CPn_0744 in contig AE001363_GR. Gene locus CP_0001 in contig AE002161_GR. Gene locus CpB0772 in contig AE009440_GR. Gene locus hemB in contig BA000008_GR.
KEGG	cpa:CP0001. cpn:CPn0744. cpt:CpB0772.
TIGR	CP_0001.
Phylogenomic databases
HOGENOM	Q9Z7G1.
OMA	KFILFGV.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0001-MON. CPNE115713:CPN0744-MON. CPNE138677:CPJ0744-MON. CPNE182082:CPB0772-MON.
BRENDA	4.2.1.24. 264832.
Family and domain databases
InterPro	IPR001731. 4pyrrol_synth_porphobiln_synth. IPR013785. Aldolase_TIM. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
ProDom	PD002304. AlaD_dehydratase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM2_CHLPN

Accession

Primary (citable) accession number: Q9Z7G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)