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Q9Z7E8

- FOLKP_CHLPN

UniProt

Q9Z7E8 - FOLKP_CHLPN

Protein

Folate synthesis bifunctional protein

Gene

folKP

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Cofactori

    Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi188 – 1881MagnesiumBy similarity
    Binding sitei196 – 1961SubstrateBy similarity
    Binding sitei268 – 2681SubstrateBy similarity
    Binding sitei288 – 2881SubstrateBy similarity
    Binding sitei358 – 3581SubstrateBy similarity
    Binding sitei394 – 3941SubstrateBy similarity
    Binding sitei428 – 4281SubstrateBy similarity
    Binding sitei430 – 4301SubstrateBy similarity

    GO - Molecular functioni

    1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. dihydropteroate synthase activity Source: UniProtKB-EC
    4. kinase activity Source: UniProtKB-KW
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-1151-MONOMER.
    CPNE115713:GHEY-792-MONOMER.
    CPNE138677:GH8N-784-MONOMER.
    CPNE182082:GH4N-811-MONOMER.
    UniPathwayiUPA00077; UER00155.
    UPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folate synthesis bifunctional protein
    Including the following 2 domains:
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name:
    PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name:
    HPPK
    Dihydropteroate synthase (EC:2.5.1.15)
    Short name:
    DHPS
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
    Gene namesi
    Name:folKP
    Synonyms:folP
    Ordered Locus Names:CPn_0758, CP_1114, CpB0786
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Folate synthesis bifunctional proteinPRO_0000168240Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0758.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z7E8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini181 – 440260Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 166166HPPKAdd
    BLAST
    Regioni228 – 2292Substrate bindingBy similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the HPPK family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0294.
    HOGENOMiHOG000063856.
    KOiK13941.
    OMAiKYVITHN.
    OrthoDBiEOG67T5P5.

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    3.30.70.560. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000550. Hppk.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF01288. HPPK. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    SSF55083. SSF55083. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    TIGR01498. folK. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z7E8-1 [UniParc]FASTAAdd to Basket

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    MSEPRFVCLS LGSNLGNRFK NLQIARTLLG EQAVLGLRSS VILETEALLL    50
    PGSPPEWDLP YFNSVLVGET TLSLRELLVT IKQIEKVVGR AEESPPWSPR 100
    TIDVDILLYG DESFCCDHTE ITIPLSNLLS RPFLIALIAS LCPYRRFCTQ 150
    GSPYHNFTFG ELAHHLPSPP GMIRRSLSPD TMLMGVVNVT NDSMSDGGMF 200
    LDPEKAVAQA EKLFTEGAAV IDFGAQATNP KVKQFLSVDQ EWERLEPVLR 250
    LLKETWSNRK QYPIISLDTF YPEIILRAMD IYPIQWINDV SGGSQSMAEV 300
    ARDCELSLVM NHSSSLPVDP KNILSFSVPI GEQLLSWGEK QLKMFSDVGL 350
    NANQVIFDPG IGFGKGAAQS LATLYEIAKF KRLGCPILIG HSRKSFLSLF 400
    GNHDPKDRDW ETVGLSILLQ QQGVDYLRVH NVAAHQKALS VAACEACAPI 450
    Length:450
    Mass (Da):49,815
    Last modified:May 1, 1999 - v1
    Checksum:iD644AB80EF4C9A8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18896.1.
    AE002161 Genomic DNA. Translation: AAF38881.1.
    BA000008 Genomic DNA. Translation: BAA98966.1.
    AE009440 Genomic DNA. Translation: AAP98715.1.
    PIRiD86585.
    G72039.
    RefSeqiNP_224953.1. NC_000922.1.
    NP_300815.1. NC_002491.1.
    NP_445651.1. NC_002179.2.
    NP_877058.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18896; AAD18896; CPn_0758.
    AAF38881; AAF38881; CP_1114.
    AAP98715; AAP98715; CpB0786.
    BAA98966; BAA98966; BAA98966.
    GeneIDi1467465.
    894959.
    919529.
    963111.
    KEGGicpa:CP1114.
    cpj:CPj0758.
    cpn:CPn0758.
    cpt:CpB0786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18896.1 .
    AE002161 Genomic DNA. Translation: AAF38881.1 .
    BA000008 Genomic DNA. Translation: BAA98966.1 .
    AE009440 Genomic DNA. Translation: AAP98715.1 .
    PIRi D86585.
    G72039.
    RefSeqi NP_224953.1. NC_000922.1.
    NP_300815.1. NC_002491.1.
    NP_445651.1. NC_002179.2.
    NP_877058.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z7E8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0758.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18896 ; AAD18896 ; CPn_0758 .
    AAF38881 ; AAF38881 ; CP_1114 .
    AAP98715 ; AAP98715 ; CpB0786 .
    BAA98966 ; BAA98966 ; BAA98966 .
    GeneIDi 1467465.
    894959.
    919529.
    963111.
    KEGGi cpa:CP1114.
    cpj:CPj0758.
    cpn:CPn0758.
    cpt:CpB0786.

    Phylogenomic databases

    eggNOGi COG0294.
    HOGENOMi HOG000063856.
    KOi K13941.
    OMAi KYVITHN.
    OrthoDBi EOG67T5P5.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00155 .
    UPA00077 ; UER00156 .
    BioCyci CPNE115711:GI7B-1151-MONOMER.
    CPNE115713:GHEY-792-MONOMER.
    CPNE138677:GH8N-784-MONOMER.
    CPNE182082:GH4N-811-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    3.30.70.560. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000550. Hppk.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF01288. HPPK. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    SSF55083. SSF55083. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    TIGR01498. folK. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiFOLKP_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z7E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3