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Q9Z7E8

- FOLKP_CHLPN

UniProt

Q9Z7E8 - FOLKP_CHLPN

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Protein

Folate synthesis bifunctional protein

Gene
folKP, folP, CPn_0758, CP_1114, CpB0786
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi188 – 1881Magnesium By similarity
Binding sitei196 – 1961Substrate By similarity
Binding sitei268 – 2681Substrate By similarity
Binding sitei288 – 2881Substrate By similarity
Binding sitei358 – 3581Substrate By similarity
Binding sitei394 – 3941Substrate By similarity
Binding sitei428 – 4281Substrate By similarity
Binding sitei430 – 4301Substrate By similarity

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. dihydropteroate synthase activity Source: UniProtKB-EC
  4. kinase activity Source: UniProtKB-KW
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-1151-MONOMER.
CPNE115713:GHEY-792-MONOMER.
CPNE138677:GH8N-784-MONOMER.
CPNE182082:GH4N-811-MONOMER.
UniPathwayiUPA00077; UER00155.
UPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Folate synthesis bifunctional protein
Including the following 2 domains:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folKP
Synonyms:folP
Ordered Locus Names:CPn_0758, CP_1114, CpB0786
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Folate synthesis bifunctional proteinPRO_0000168240Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0758.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7E8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 440260Pterin-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 166166HPPKAdd
BLAST
Regioni228 – 2292Substrate binding By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the HPPK family.

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000063856.
KOiK13941.
OMAiKYVITHN.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z7E8-1 [UniParc]FASTAAdd to Basket

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MSEPRFVCLS LGSNLGNRFK NLQIARTLLG EQAVLGLRSS VILETEALLL    50
PGSPPEWDLP YFNSVLVGET TLSLRELLVT IKQIEKVVGR AEESPPWSPR 100
TIDVDILLYG DESFCCDHTE ITIPLSNLLS RPFLIALIAS LCPYRRFCTQ 150
GSPYHNFTFG ELAHHLPSPP GMIRRSLSPD TMLMGVVNVT NDSMSDGGMF 200
LDPEKAVAQA EKLFTEGAAV IDFGAQATNP KVKQFLSVDQ EWERLEPVLR 250
LLKETWSNRK QYPIISLDTF YPEIILRAMD IYPIQWINDV SGGSQSMAEV 300
ARDCELSLVM NHSSSLPVDP KNILSFSVPI GEQLLSWGEK QLKMFSDVGL 350
NANQVIFDPG IGFGKGAAQS LATLYEIAKF KRLGCPILIG HSRKSFLSLF 400
GNHDPKDRDW ETVGLSILLQ QQGVDYLRVH NVAAHQKALS VAACEACAPI 450
Length:450
Mass (Da):49,815
Last modified:May 1, 1999 - v1
Checksum:iD644AB80EF4C9A8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18896.1.
AE002161 Genomic DNA. Translation: AAF38881.1.
BA000008 Genomic DNA. Translation: BAA98966.1.
AE009440 Genomic DNA. Translation: AAP98715.1.
PIRiD86585.
G72039.
RefSeqiNP_224953.1. NC_000922.1.
NP_300815.1. NC_002491.1.
NP_445651.1. NC_002179.2.
NP_877058.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18896; AAD18896; CPn_0758.
AAF38881; AAF38881; CP_1114.
AAP98715; AAP98715; CpB0786.
BAA98966; BAA98966; BAA98966.
GeneIDi1467465.
894959.
919529.
963111.
KEGGicpa:CP1114.
cpj:CPj0758.
cpn:CPn0758.
cpt:CpB0786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18896.1 .
AE002161 Genomic DNA. Translation: AAF38881.1 .
BA000008 Genomic DNA. Translation: BAA98966.1 .
AE009440 Genomic DNA. Translation: AAP98715.1 .
PIRi D86585.
G72039.
RefSeqi NP_224953.1. NC_000922.1.
NP_300815.1. NC_002491.1.
NP_445651.1. NC_002179.2.
NP_877058.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z7E8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18896 ; AAD18896 ; CPn_0758 .
AAF38881 ; AAF38881 ; CP_1114 .
AAP98715 ; AAP98715 ; CpB0786 .
BAA98966 ; BAA98966 ; BAA98966 .
GeneIDi 1467465.
894959.
919529.
963111.
KEGGi cpa:CP1114.
cpj:CPj0758.
cpn:CPn0758.
cpt:CpB0786.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000063856.
KOi K13941.
OMAi KYVITHN.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00155 .
UPA00077 ; UER00156 .
BioCyci CPNE115711:GI7B-1151-MONOMER.
CPNE115713:GHEY-792-MONOMER.
CPNE138677:GH8N-784-MONOMER.
CPNE182082:GH4N-811-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiFOLKP_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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