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Q9Z7E8 (FOLKP_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Folate synthesis bifunctional protein

Including the following 2 domains:

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    EC=2.7.6.3
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name=PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name=HPPK
  2. Dihydropteroate synthase
    Short name=DHPS
    EC=2.5.1.15
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
Gene names
Name:folKP
Synonyms:folP
Ordered Locus Names:CPn_0758, CP_1114, CpB0786
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Sequence similarities

In the N-terminal section; belongs to the HPPK family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Folate synthesis bifunctional protein
PRO_0000168240

Regions

Domain181 – 440260Pterin-binding
Region1 – 166166HPPK
Region228 – 2292Substrate binding By similarity

Sites

Metal binding1881Magnesium By similarity
Binding site1961Substrate By similarity
Binding site2681Substrate By similarity
Binding site2881Substrate By similarity
Binding site3581Substrate By similarity
Binding site3941Substrate By similarity
Binding site4281Substrate By similarity
Binding site4301Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z7E8 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D644AB80EF4C9A8C

FASTA45049,815
        10         20         30         40         50         60 
MSEPRFVCLS LGSNLGNRFK NLQIARTLLG EQAVLGLRSS VILETEALLL PGSPPEWDLP 

        70         80         90        100        110        120 
YFNSVLVGET TLSLRELLVT IKQIEKVVGR AEESPPWSPR TIDVDILLYG DESFCCDHTE 

       130        140        150        160        170        180 
ITIPLSNLLS RPFLIALIAS LCPYRRFCTQ GSPYHNFTFG ELAHHLPSPP GMIRRSLSPD 

       190        200        210        220        230        240 
TMLMGVVNVT NDSMSDGGMF LDPEKAVAQA EKLFTEGAAV IDFGAQATNP KVKQFLSVDQ 

       250        260        270        280        290        300 
EWERLEPVLR LLKETWSNRK QYPIISLDTF YPEIILRAMD IYPIQWINDV SGGSQSMAEV 

       310        320        330        340        350        360 
ARDCELSLVM NHSSSLPVDP KNILSFSVPI GEQLLSWGEK QLKMFSDVGL NANQVIFDPG 

       370        380        390        400        410        420 
IGFGKGAAQS LATLYEIAKF KRLGCPILIG HSRKSFLSLF GNHDPKDRDW ETVGLSILLQ 

       430        440        450 
QQGVDYLRVH NVAAHQKALS VAACEACAPI 

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001363 Genomic DNA. Translation: AAD18896.1.
AE002161 Genomic DNA. Translation: AAF38881.1.
BA000008 Genomic DNA. Translation: BAA98966.1.
AE009440 Genomic DNA. Translation: AAP98715.1.
PIRD86585.
G72039.
RefSeqNP_224953.1. NC_000922.1.
NP_300815.1. NC_002491.1.
NP_445651.1. NC_002179.2.
NP_877058.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z7E8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING115713.CPn0758.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD18896; AAD18896; CPn_0758.
AAF38881; AAF38881; CP_1114.
AAP98715; AAP98715; CpB0786.
BAA98966; BAA98966; BAA98966.
GeneID1467465.
894959.
919529.
963111.
KEGGcpa:CP1114.
cpj:CPj0758.
cpn:CPn0758.
cpt:CpB0786.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0294.
HOGENOMHOG000063856.
KOK13941.
OMAMYVLDQD.
OrthoDBEOG67T5P5.
ProtClustDBCLSK871487.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-1151-MONOMER.
CPNE115713:GHEY-792-MONOMER.
CPNE138677:GH8N-784-MONOMER.
CPNE182082:GH4N-811-MONOMER.
UniPathwayUPA00077; UER00155.
UPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLKP_CHLPN
AccessionPrimary (citable) accession number: Q9Z7E8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways