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Protein

Folate synthesis bifunctional protein

Gene

folKP

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 7,8-dihydroneopterin aldolase (folB), 7,8-dihydroneopterin aldolase (folB), Probable dihydroneopterin aldolase (folB)
  4. Folate synthesis bifunctional protein (folKP)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Folate synthesis bifunctional protein (folKP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188MagnesiumBy similarity1
Binding sitei2286-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2686-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2886-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei3586-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei3946-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Multifunctional enzyme, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155
UPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Folate synthesis bifunctional protein
Including the following 2 domains:
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC:2.7.6.3)
Short name:
HPPK
Alternative name(s):
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
PPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folKP
Synonyms:folP
Ordered Locus Names:CPn_0758, CP_1114, CpB0786
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682401 – 450Folate synthesis bifunctional proteinAdd BLAST450

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0786

Structurei

3D structure databases

ProteinModelPortaliQ9Z7E8
SMRiQ9Z7E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 440Pterin-bindingPROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 166HPPKAdd BLAST166
Regioni183 – 450DHPSAdd BLAST268
Regioni428 – 4306-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

In the C-terminal section; belongs to the DHPS family.Curated
In the N-terminal section; belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
COG0801 LUCA
HOGENOMiHOG000063856
KOiK13941
OMAiSLWETEP
OrthoDBiPOG091H00BJ

Family and domain databases

CDDicd00739 DHPS, 1 hit
cd00483 HPPK, 1 hit
Gene3Di3.20.20.20, 1 hit
3.30.70.560, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000550 Hppk
IPR035907 Hppk_sf
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
SSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
TIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPRFVCLS LGSNLGNRFK NLQIARTLLG EQAVLGLRSS VILETEALLL
60 70 80 90 100
PGSPPEWDLP YFNSVLVGET TLSLRELLVT IKQIEKVVGR AEESPPWSPR
110 120 130 140 150
TIDVDILLYG DESFCCDHTE ITIPLSNLLS RPFLIALIAS LCPYRRFCTQ
160 170 180 190 200
GSPYHNFTFG ELAHHLPSPP GMIRRSLSPD TMLMGVVNVT NDSMSDGGMF
210 220 230 240 250
LDPEKAVAQA EKLFTEGAAV IDFGAQATNP KVKQFLSVDQ EWERLEPVLR
260 270 280 290 300
LLKETWSNRK QYPIISLDTF YPEIILRAMD IYPIQWINDV SGGSQSMAEV
310 320 330 340 350
ARDCELSLVM NHSSSLPVDP KNILSFSVPI GEQLLSWGEK QLKMFSDVGL
360 370 380 390 400
NANQVIFDPG IGFGKGAAQS LATLYEIAKF KRLGCPILIG HSRKSFLSLF
410 420 430 440 450
GNHDPKDRDW ETVGLSILLQ QQGVDYLRVH NVAAHQKALS VAACEACAPI
Length:450
Mass (Da):49,815
Last modified:May 1, 1999 - v1
Checksum:iD644AB80EF4C9A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18896.1
AE002161 Genomic DNA Translation: AAF38881.1
BA000008 Genomic DNA Translation: BAA98966.1
AE009440 Genomic DNA Translation: AAP98715.1
PIRiD86585
G72039
RefSeqiNP_224953.1, NC_000922.1
WP_010883395.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18896; AAD18896; CPn_0758
AAF38881; AAF38881; CP_1114
AAP98715; AAP98715; CpB0786
BAA98966; BAA98966; BAA98966
GeneIDi894959
KEGGicpa:CP_1114
cpj:folP
cpn:CPn0758
cpt:CpB0786
PATRICifig|115713.3.peg.835

Similar proteinsi

Entry informationi

Entry nameiFOLKP_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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