Reviewed, UniProtKB/Swiss-Prot Q9Z7D1 (NTPA_CHLPN)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CPn_0775, CP_1097, CPj0775, CpB0802

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Nucleoside-triphosphatase		PRO_0000178150
Experimental info
	Sequence conflict	44	1	E → G in AAD18913. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Z7D1-1 [UniParc]. Last modified August 30, 2002. Version 2. Checksum: 3B19BBFAA02062C3	FASTA	206	23,135
	10 20 30 40 50 60 MKIVIASSHG YKIRETKTFL KRLGDFDIFS LSDFPDYKLP QEQEDSITAN ALTKGIHAAN 70 80 90 100 110 120 HLGCWVIADD TMLRVPALNG LPGPLSANFA GVGAYDKDHR KKLLDLMSSL ESLVDRSAYF 130 140 150 160 170 180 ECCVVLVSPN QEIFKTYGIC EGYISHQEKG SSGFGYDPIF VKYDYKQTFA ELSEDVKNQV 190 200 SHRAKALQKL APHLQSLFEK HLLTRD

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD18913.1. AE002161 Genomic DNA. Translation: AAF73731.1. BA000008 Genomic DNA. Translation: BAA98983.1. AE017159 Genomic DNA. Translation: AAP98732.1.
PIR	B72036. E86587.
RefSeq	NP_224970.1. NP_300832.1. NP_445634.1. NP_877075.1.
3D structure databases
HSSP	HSSP built from PDB template 1B78 based on UniProtKB Q57679.
ModBase	Search...
Genome annotation databases
GeneID	1467482. 895062. 919544. 963585.
GenomeReviews	Gene locus CP_1097 in contig AE002161_GR. Gene locus CpB0802 in contig AE009440_GR. Gene locus CPj0775 in contig BA000008_GR. Gene locus CPn_0775 in contig AE001363_GR.
KEGG	cpa:CP1097. cpj:CPj0775. cpn:CPn0775. cpt:CpB0802.
TIGR	CP_1097.
Phylogenomic databases
HOGENOM	Q9Z7D1.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_1097-MON. CPNE115713:CPN0775-MON. CPNE138677:CPJ0775-MON. CPNE182082:CPB0802-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

NTPA_CHLPN

Accession

Primary (citable) accession number: Q9Z7D1
Secondary accession number(s): Q9JS41

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	August 30, 2002
Last modified:	July 22, 2008
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)