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Q9Z7A4

- SYW_CHLPN

UniProt

Q9Z7A4 - SYW_CHLPN

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei205 – 2051ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-1105-MONOMER.
    CPNE115713:GHEY-837-MONOMER.
    CPNE138677:GH8N-829-MONOMER.
    CPNE182082:GH4N-857-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase (EC:6.1.1.2)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:trpS
    Ordered Locus Names:CPn_0802, CP_1069, CpB0831
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Tryptophan--tRNA ligasePRO_0000136619Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi115713.CPn0802.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z7A4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi13 – 219"HIGH" region
    Motifi202 – 2065"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059941.
    KOiK01867.
    OMAiKGCETAR.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z7A4-1 [UniParc]FASTAAdd to Basket

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    MNKKKRVLTG DRPTGKLHLG HWVGSIKNRL ELQNSPEYDC FFIIADLHTL    50
    TTKIRKEEVL DVDNHIYEVL ADWLSVGIDP TKSIIYLQSA IPEIYELHLL 100
    FSMLISINRV MGIPSLKDMA RNASIEEGSL SYGLIGYPIL QSADILLAKA 150
    QFVPVGKDNE AHVELTRDIA RNFNRLYGQV FPEPEVLQGE LTSLVGIDGQ 200
    GKMSKSANNA IYLSDSDATI TEKVRKMYTD PNRIRATTPG RVEGNPLFIY 250
    HDIFNPHKDE VEEFKARYRQ GCIKDIEVKA RLAEELIHFL KPIKERRSEF 300
    LSKPLALQNV LEDGTHKMRE VAKVTMEEVH DKFGFSHKWR SLLK 344
    Length:344
    Mass (Da):39,283
    Last modified:May 1, 1999 - v1
    Checksum:i6204B07F34385169
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18940.1.
    AE002161 Genomic DNA. Translation: AAF38841.1.
    BA000008 Genomic DNA. Translation: BAA99010.1.
    AE009440 Genomic DNA. Translation: AAP98760.1.
    PIRiC72034.
    H86590.
    RefSeqiNP_224997.1. NC_000922.1.
    NP_300859.1. NC_002491.1.
    NP_445606.1. NC_002179.2.
    NP_877103.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18940; AAD18940; CPn_0802.
    AAF38841; AAF38841; CP_1069.
    AAP98760; AAP98760; CpB0831.
    BAA99010; BAA99010; BAA99010.
    GeneIDi1467510.
    895541.
    919559.
    963553.
    KEGGicpa:CP1069.
    cpj:CPj0802.
    cpn:CPn0802.
    cpt:CpB0831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18940.1 .
    AE002161 Genomic DNA. Translation: AAF38841.1 .
    BA000008 Genomic DNA. Translation: BAA99010.1 .
    AE009440 Genomic DNA. Translation: AAP98760.1 .
    PIRi C72034.
    H86590.
    RefSeqi NP_224997.1. NC_000922.1.
    NP_300859.1. NC_002491.1.
    NP_445606.1. NC_002179.2.
    NP_877103.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z7A4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0802.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18940 ; AAD18940 ; CPn_0802 .
    AAF38841 ; AAF38841 ; CP_1069 .
    AAP98760 ; AAP98760 ; CpB0831 .
    BAA99010 ; BAA99010 ; BAA99010 .
    GeneIDi 1467510.
    895541.
    919559.
    963553.
    KEGGi cpa:CP1069.
    cpj:CPj0802.
    cpn:CPn0802.
    cpt:CpB0831.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059941.
    KOi K01867.
    OMAi KGCETAR.
    OrthoDBi EOG686NJQ.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-1105-MONOMER.
    CPNE115713:GHEY-837-MONOMER.
    CPNE138677:GH8N-829-MONOMER.
    CPNE182082:GH4N-857-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiSYW_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z7A4
    Secondary accession number(s): Q9JQ80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3