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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144L-tryptophanUniRule annotation1
Binding sitei194ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATPUniRule annotation3
Nucleotide bindingi20 – 21ATPUniRule annotation2
Nucleotide bindingi156 – 158ATPUniRule annotation3
Nucleotide bindingi202 – 206ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:CPn_0802, CP_1069, CpB0831
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366191 – 344Tryptophan--tRNA ligaseAdd BLAST344

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0831

Structurei

3D structure databases

ProteinModelPortaliQ9Z7A4
SMRiQ9Z7A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 21"HIGH" regionUniRule annotation9
Motifi202 – 206"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059941
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z7A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKKRVLTG DRPTGKLHLG HWVGSIKNRL ELQNSPEYDC FFIIADLHTL
60 70 80 90 100
TTKIRKEEVL DVDNHIYEVL ADWLSVGIDP TKSIIYLQSA IPEIYELHLL
110 120 130 140 150
FSMLISINRV MGIPSLKDMA RNASIEEGSL SYGLIGYPIL QSADILLAKA
160 170 180 190 200
QFVPVGKDNE AHVELTRDIA RNFNRLYGQV FPEPEVLQGE LTSLVGIDGQ
210 220 230 240 250
GKMSKSANNA IYLSDSDATI TEKVRKMYTD PNRIRATTPG RVEGNPLFIY
260 270 280 290 300
HDIFNPHKDE VEEFKARYRQ GCIKDIEVKA RLAEELIHFL KPIKERRSEF
310 320 330 340
LSKPLALQNV LEDGTHKMRE VAKVTMEEVH DKFGFSHKWR SLLK
Length:344
Mass (Da):39,283
Last modified:May 1, 1999 - v1
Checksum:i6204B07F34385169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18940.1
AE002161 Genomic DNA Translation: AAF38841.1
BA000008 Genomic DNA Translation: BAA99010.1
AE009440 Genomic DNA Translation: AAP98760.1
PIRiC72034
H86590
RefSeqiNP_224997.1, NC_000922.1
WP_010883439.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18940; AAD18940; CPn_0802
AAF38841; AAF38841; CP_1069
AAP98760; AAP98760; CpB0831
BAA99010; BAA99010; BAA99010
GeneIDi895541
KEGGicpa:CP_1069
cpj:trpS
cpn:CPn0802
cpt:CpB0831
PATRICifig|115713.3.peg.881

Similar proteinsi

Entry informationi

Entry nameiSYW_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7A4
Secondary accession number(s): Q9JQ80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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