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Q9Z7A4

- SYW_CHLPN

UniProt

Q9Z7A4 - SYW_CHLPN

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei205 – 2051ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-1105-MONOMER.
CPNE115713:GHEY-837-MONOMER.
CPNE138677:GH8N-829-MONOMER.
CPNE182082:GH4N-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:CPn_0802, CP_1069, CpB0831
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Tryptophan--tRNA ligasePRO_0000136619Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0802.

Structurei

3D structure databases

ProteinModelPortaliQ9Z7A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi13 – 219"HIGH" region
Motifi202 – 2065"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059941.
KOiK01867.
OMAiKGCETAR.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z7A4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKKKRVLTG DRPTGKLHLG HWVGSIKNRL ELQNSPEYDC FFIIADLHTL
60 70 80 90 100
TTKIRKEEVL DVDNHIYEVL ADWLSVGIDP TKSIIYLQSA IPEIYELHLL
110 120 130 140 150
FSMLISINRV MGIPSLKDMA RNASIEEGSL SYGLIGYPIL QSADILLAKA
160 170 180 190 200
QFVPVGKDNE AHVELTRDIA RNFNRLYGQV FPEPEVLQGE LTSLVGIDGQ
210 220 230 240 250
GKMSKSANNA IYLSDSDATI TEKVRKMYTD PNRIRATTPG RVEGNPLFIY
260 270 280 290 300
HDIFNPHKDE VEEFKARYRQ GCIKDIEVKA RLAEELIHFL KPIKERRSEF
310 320 330 340
LSKPLALQNV LEDGTHKMRE VAKVTMEEVH DKFGFSHKWR SLLK
Length:344
Mass (Da):39,283
Last modified:May 1, 1999 - v1
Checksum:i6204B07F34385169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18940.1.
AE002161 Genomic DNA. Translation: AAF38841.1.
BA000008 Genomic DNA. Translation: BAA99010.1.
AE009440 Genomic DNA. Translation: AAP98760.1.
PIRiC72034.
H86590.
RefSeqiNP_224997.1. NC_000922.1.
NP_300859.1. NC_002491.1.
NP_445606.1. NC_002179.2.
NP_877103.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18940; AAD18940; CPn_0802.
AAF38841; AAF38841; CP_1069.
AAP98760; AAP98760; CpB0831.
BAA99010; BAA99010; BAA99010.
GeneIDi1467510.
895541.
919559.
963553.
KEGGicpa:CP1069.
cpj:CPj0802.
cpn:CPn0802.
cpt:CpB0831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18940.1 .
AE002161 Genomic DNA. Translation: AAF38841.1 .
BA000008 Genomic DNA. Translation: BAA99010.1 .
AE009440 Genomic DNA. Translation: AAP98760.1 .
PIRi C72034.
H86590.
RefSeqi NP_224997.1. NC_000922.1.
NP_300859.1. NC_002491.1.
NP_445606.1. NC_002179.2.
NP_877103.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z7A4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0802.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18940 ; AAD18940 ; CPn_0802 .
AAF38841 ; AAF38841 ; CP_1069 .
AAP98760 ; AAP98760 ; CpB0831 .
BAA99010 ; BAA99010 ; BAA99010 .
GeneIDi 1467510.
895541.
919559.
963553.
KEGGi cpa:CP1069.
cpj:CPj0802.
cpn:CPn0802.
cpt:CpB0831.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059941.
KOi K01867.
OMAi KGCETAR.
OrthoDBi EOG686NJQ.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-1105-MONOMER.
CPNE115713:GHEY-837-MONOMER.
CPNE138677:GH8N-829-MONOMER.
CPNE182082:GH4N-857-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiSYW_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7A4
Secondary accession number(s): Q9JQ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3