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Q9Z7A4 (SYW_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:CPn_0802, CP_1069, CpB0831
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140_B

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Tryptophan--tRNA ligase HAMAP-Rule MF_00140_B
PRO_0000136619

Regions

Motif13 – 219"HIGH" region HAMAP-Rule MF_00140_B
Motif202 – 2065"KMSKS" region HAMAP-Rule MF_00140_B

Sites

Binding site2051ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z7A4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6204B07F34385169

FASTA34439,283
        10         20         30         40         50         60 
MNKKKRVLTG DRPTGKLHLG HWVGSIKNRL ELQNSPEYDC FFIIADLHTL TTKIRKEEVL 

        70         80         90        100        110        120 
DVDNHIYEVL ADWLSVGIDP TKSIIYLQSA IPEIYELHLL FSMLISINRV MGIPSLKDMA 

       130        140        150        160        170        180 
RNASIEEGSL SYGLIGYPIL QSADILLAKA QFVPVGKDNE AHVELTRDIA RNFNRLYGQV 

       190        200        210        220        230        240 
FPEPEVLQGE LTSLVGIDGQ GKMSKSANNA IYLSDSDATI TEKVRKMYTD PNRIRATTPG 

       250        260        270        280        290        300 
RVEGNPLFIY HDIFNPHKDE VEEFKARYRQ GCIKDIEVKA RLAEELIHFL KPIKERRSEF 

       310        320        330        340 
LSKPLALQNV LEDGTHKMRE VAKVTMEEVH DKFGFSHKWR SLLK 

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001363 Genomic DNA. Translation: AAD18940.1.
AE002161 Genomic DNA. Translation: AAF38841.1.
BA000008 Genomic DNA. Translation: BAA99010.1.
AE009440 Genomic DNA. Translation: AAP98760.1.
PIRC72034.
H86590.
RefSeqNP_224997.1. NC_000922.1.
NP_300859.1. NC_002491.1.
NP_445606.1. NC_002179.2.
NP_877103.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z7A4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING115713.CPn0802.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD18940; AAD18940; CPn_0802.
AAF38841; AAF38841; CP_1069.
AAP98760; AAP98760; CpB0831.
BAA99010; BAA99010; BAA99010.
GeneID1467510.
895541.
919559.
963553.
KEGGcpa:CP1069.
cpj:CPj0802.
cpn:CPn0802.
cpt:CpB0831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059941.
KOK01867.
OMAKQPVIEG.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-1105-MONOMER.
CPNE115713:GHEY-837-MONOMER.
CPNE138677:GH8N-829-MONOMER.
CPNE182082:GH4N-857-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_CHLPN
AccessionPrimary (citable) accession number: Q9Z7A4
Secondary accession number(s): Q9JQ80
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries