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Q9Z774

- LIPA_CHLPN

UniProt

Q9Z774 - LIPA_CHLPN

Protein

Lipoyl synthase

Gene

lipA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.UniRule annotation

    Catalytic activityi

    Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi52 – 521Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi57 – 571Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi63 – 631Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi78 – 781Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi82 – 821Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi85 – 851Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. lipoate synthase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein lipoylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-1074-MONOMER.
    CPNE115713:GHEY-867-MONOMER.
    CPNE138677:GH8N-859-MONOMER.
    CPNE182082:GH4N-887-MONOMER.
    UniPathwayiUPA00538; UER00593.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoyl synthaseUniRule annotation (EC:2.8.1.8UniRule annotation)
    Alternative name(s):
    Lip-synUniRule annotation
    Short name:
    LSUniRule annotation
    Lipoate synthaseUniRule annotation
    Lipoic acid synthaseUniRule annotation
    Sulfur insertion protein LipAUniRule annotation
    Gene namesi
    Name:lipAUniRule annotation
    Ordered Locus Names:CPn_0832, CP_1038, CpB0861
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Lipoyl synthasePRO_0000102304Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0832.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z774.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. Lipoyl synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0320.
    HOGENOMiHOG000235997.
    KOiK03644.
    OMAiHTICQEA.
    OrthoDBiEOG6038ZS.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00206. Lipoyl_synth.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view]
    PANTHERiPTHR10949. PTHR10949. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00510. lipA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z774-1 [UniParc]FASTAAdd to Basket

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    MKCRPTLNTD QPRVRKKLPE RFPKWLQRPL PQGSAFHATD ATIKRSGMPT    50
    VCEEALCPNR AECWSRKTAT YLALGDVCTR SCGFCNIGHS KTPPALDPTE 100
    PERIALSAKE LGLKHVVITM VARDDLEDGG AQGLVDIIQK LREELPQATT 150
    EVLASDFQGN VSALHTLLDS GITIYNHNVE TVARLSPLVR HKATYARSMF 200
    MLEQAANYLP DLKIKSGIMV GLGEMEGEVK QTLQDLASIG VRIVTIGQYL 250
    RPSRKHLQVK SYVTPETFDY YRRVGEAMGL FVYAGPFVRS SFNADMILAS 300
    VQDKASA 307
    Length:307
    Mass (Da):33,993
    Last modified:May 1, 1999 - v1
    Checksum:iF893D50F7BC90062
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18969.1.
    AE002161 Genomic DNA. Translation: AAF38813.1.
    BA000008 Genomic DNA. Translation: BAA99040.1.
    AB035942 Genomic DNA. Translation: BAA88650.1.
    AE009440 Genomic DNA. Translation: AAP98790.1.
    PIRiB72031.
    F86594.
    RefSeqiNP_225027.1. NC_000922.1.
    NP_300889.1. NC_002491.1.
    NP_445575.1. NC_002179.2.
    NP_877133.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18969; AAD18969; CPn_0832.
    AAF38813; AAF38813; CP_1038.
    AAP98790; AAP98790; CpB0861.
    BAA99040; BAA99040; BAA99040.
    GeneIDi1467540.
    894731.
    919598.
    963516.
    KEGGicpa:CP1038.
    cpj:CPj0832.
    cpn:CPn0832.
    cpt:CpB0861.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18969.1 .
    AE002161 Genomic DNA. Translation: AAF38813.1 .
    BA000008 Genomic DNA. Translation: BAA99040.1 .
    AB035942 Genomic DNA. Translation: BAA88650.1 .
    AE009440 Genomic DNA. Translation: AAP98790.1 .
    PIRi B72031.
    F86594.
    RefSeqi NP_225027.1. NC_000922.1.
    NP_300889.1. NC_002491.1.
    NP_445575.1. NC_002179.2.
    NP_877133.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z774.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18969 ; AAD18969 ; CPn_0832 .
    AAF38813 ; AAF38813 ; CP_1038 .
    AAP98790 ; AAP98790 ; CpB0861 .
    BAA99040 ; BAA99040 ; BAA99040 .
    GeneIDi 1467540.
    894731.
    919598.
    963516.
    KEGGi cpa:CP1038.
    cpj:CPj0832.
    cpn:CPn0832.
    cpt:CpB0861.

    Phylogenomic databases

    eggNOGi COG0320.
    HOGENOMi HOG000235997.
    KOi K03644.
    OMAi HTICQEA.
    OrthoDBi EOG6038ZS.

    Enzyme and pathway databases

    UniPathwayi UPA00538 ; UER00593 .
    BioCyci CPNE115711:GI7B-1074-MONOMER.
    CPNE115713:GHEY-867-MONOMER.
    CPNE138677:GH8N-859-MONOMER.
    CPNE182082:GH4N-887-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00206. Lipoyl_synth.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view ]
    PANTHERi PTHR10949. PTHR10949. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00510. lipA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "Genomic sequence comparison of two unrelated isolates of Chlamydia pneumoniae from Japan and U.S."
      Hirakawa H., Shirai M., Kuhara S.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: J138.
    5. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiLIPA_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z774
    Secondary accession number(s): Q9JQ18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3