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Q9Z755

- PCKG_CHLPN

UniProt

Q9Z755 - PCKG_CHLPN

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, CPn_0851, CP_1018, CpB0880
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741Substrate By similarity
Binding sitei216 – 2161Substrate; via amide nitrogen By similarity
Metal bindingi223 – 2231Manganese By similarity
Binding sitei223 – 2231Substrate By similarity
Metal bindingi243 – 2431Manganese; via tele nitrogen By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei267 – 2671 By similarity
Metal bindingi290 – 2901Manganese By similarity
Binding sitei381 – 3811GTP By similarity
Binding sitei412 – 4121GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi266 – 2716GTP By similarity
Nucleotide bindingi506 – 5094GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-1053-MONOMER.
CPNE115713:GHEY-887-MONOMER.
CPNE138677:GH8N-879-MONOMER.
CPNE182082:GH4N-907-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:CPn_0851, CP_1018, CpB0880
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_0000103598Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0851.

Structurei

3D structure databases

ProteinModelPortaliQ9Z755.
SMRiQ9Z755. Positions 8-599.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 3813Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiQAVDERF.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z755-1 [UniParc]FASTAAdd to Basket

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MVWSTNIKHE GLKSWIDEVA KLTTPKDIRL CDGSDTEYDE LCTLMESTGT    50
MIRLNPEFHP NCFLVRSSAD DVARVEQFTF ICTSTEAEAG PTNNWRDPQE 100
MRRELHQLFR GCMQGRTLYI VPFCMGPLDS PFSIVGVELT DSPYVVCSMK 150
IMTRMGDDVL RSLGTSGKFL KCLHSVGKPL SPGEADVSWP CNPKSMRIVH 200
FQDDSSVMSF GSGYGGNALL GKKCVALRLA SYMAKSQGWL AEHMLIIGIT 250
NPEGKKKYFS ASFPSACGKT NLAMLMPKLP GWKIECIGDD IAWIRPGRDG 300
RLYAVNPEYG FFGVAPGTSE RTNPNALATC RSNSIFTNVA LTADGDVWWE 350
GLTEQPPEPL TDWLGKPWKP GGSPAAHPNS RFTAPLRQCP SLDPEWNSPQ 400
GVPLDAIIFG GRRSETIPLV YEALSWEHGV TIGAGMSSTT TAAIVGQLGK 450
LRHDPFAMLP FCGYNMAYYF QHWLSFAENR SLKLPKIFGV NWFRKNNQGE 500
FLWPGFSENL RVLEWIFQRT DGLEDIAERT PIGYLPNIQK FNLNGLNLDL 550
QTVQELFSVD AEGWLAEVEN IGEYLKIFGS DCPQQITDEL LRIKSELKEK 600
Length:600
Mass (Da):66,992
Last modified:May 1, 1999 - v1
Checksum:i79590DC1A0A9932A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18989.1.
AE002161 Genomic DNA. Translation: AAF73723.1.
BA000008 Genomic DNA. Translation: BAA99059.1.
AE009440 Genomic DNA. Translation: AAP98809.1.
PIRiA86597.
E72027.
RefSeqiNP_225046.1. NC_000922.1.
NP_300908.1. NC_002491.1.
NP_445555.1. NC_002179.2.
NP_877152.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18989; AAD18989; CPn_0851.
AAF73723; AAF73723; CP_1018.
AAP98809; AAP98809; CpB0880.
BAA99059; BAA99059; BAA99059.
GeneIDi1467559.
895150.
919614.
963494.
KEGGicpa:CP1018.
cpj:CPj0851.
cpn:CPn0851.
cpt:CpB0880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD18989.1 .
AE002161 Genomic DNA. Translation: AAF73723.1 .
BA000008 Genomic DNA. Translation: BAA99059.1 .
AE009440 Genomic DNA. Translation: AAP98809.1 .
PIRi A86597.
E72027.
RefSeqi NP_225046.1. NC_000922.1.
NP_300908.1. NC_002491.1.
NP_445555.1. NC_002179.2.
NP_877152.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z755.
SMRi Q9Z755. Positions 8-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0851.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18989 ; AAD18989 ; CPn_0851 .
AAF73723 ; AAF73723 ; CP_1018 .
AAP98809 ; AAP98809 ; CpB0880 .
BAA99059 ; BAA99059 ; BAA99059 .
GeneIDi 1467559.
895150.
919614.
963494.
KEGGi cpa:CP1018.
cpj:CPj0851.
cpn:CPn0851.
cpt:CpB0880.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi QAVDERF.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci CPNE115711:GI7B-1053-MONOMER.
CPNE115713:GHEY-887-MONOMER.
CPNE138677:GH8N-879-MONOMER.
CPNE182082:GH4N-907-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiPCKG_CHLPN
AccessioniPrimary (citable) accession number: Q9Z755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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