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Q9Z755

- PCKG_CHLPN

UniProt

Q9Z755 - PCKG_CHLPN

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn(2+) ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741SubstrateUniRule annotation
Binding sitei216 – 2161Substrate; via amide nitrogenUniRule annotation
Metal bindingi223 – 2231ManganeseUniRule annotation
Binding sitei223 – 2231SubstrateUniRule annotation
Metal bindingi243 – 2431Manganese; via tele nitrogenUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Active sitei267 – 2671UniRule annotation
Metal bindingi290 – 2901ManganeseUniRule annotation
Binding sitei381 – 3811GTPUniRule annotation
Binding sitei412 – 4121GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi266 – 2716GTPUniRule annotation
Nucleotide bindingi506 – 5094GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-1053-MONOMER.
CPNE115713:GHEY-887-MONOMER.
CPNE138677:GH8N-879-MONOMER.
CPNE182082:GH4N-907-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:CPn_0851, CP_1018, CpB0880
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103598Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0851.

Structurei

3D structure databases

ProteinModelPortaliQ9Z755.
SMRiQ9Z755. Positions 8-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 3813Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiQAVDERF.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z755-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVWSTNIKHE GLKSWIDEVA KLTTPKDIRL CDGSDTEYDE LCTLMESTGT
60 70 80 90 100
MIRLNPEFHP NCFLVRSSAD DVARVEQFTF ICTSTEAEAG PTNNWRDPQE
110 120 130 140 150
MRRELHQLFR GCMQGRTLYI VPFCMGPLDS PFSIVGVELT DSPYVVCSMK
160 170 180 190 200
IMTRMGDDVL RSLGTSGKFL KCLHSVGKPL SPGEADVSWP CNPKSMRIVH
210 220 230 240 250
FQDDSSVMSF GSGYGGNALL GKKCVALRLA SYMAKSQGWL AEHMLIIGIT
260 270 280 290 300
NPEGKKKYFS ASFPSACGKT NLAMLMPKLP GWKIECIGDD IAWIRPGRDG
310 320 330 340 350
RLYAVNPEYG FFGVAPGTSE RTNPNALATC RSNSIFTNVA LTADGDVWWE
360 370 380 390 400
GLTEQPPEPL TDWLGKPWKP GGSPAAHPNS RFTAPLRQCP SLDPEWNSPQ
410 420 430 440 450
GVPLDAIIFG GRRSETIPLV YEALSWEHGV TIGAGMSSTT TAAIVGQLGK
460 470 480 490 500
LRHDPFAMLP FCGYNMAYYF QHWLSFAENR SLKLPKIFGV NWFRKNNQGE
510 520 530 540 550
FLWPGFSENL RVLEWIFQRT DGLEDIAERT PIGYLPNIQK FNLNGLNLDL
560 570 580 590 600
QTVQELFSVD AEGWLAEVEN IGEYLKIFGS DCPQQITDEL LRIKSELKEK
Length:600
Mass (Da):66,992
Last modified:May 1, 1999 - v1
Checksum:i79590DC1A0A9932A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18989.1.
AE002161 Genomic DNA. Translation: AAF73723.1.
BA000008 Genomic DNA. Translation: BAA99059.1.
AE009440 Genomic DNA. Translation: AAP98809.1.
PIRiA86597.
E72027.
RefSeqiNP_225046.1. NC_000922.1.
NP_300908.1. NC_002491.1.
NP_445555.1. NC_002179.2.
NP_877152.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18989; AAD18989; CPn_0851.
AAF73723; AAF73723; CP_1018.
AAP98809; AAP98809; CpB0880.
BAA99059; BAA99059; BAA99059.
GeneIDi1467559.
895150.
919614.
963494.
KEGGicpa:CP1018.
cpj:CPj0851.
cpn:CPn0851.
cpt:CpB0880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18989.1 .
AE002161 Genomic DNA. Translation: AAF73723.1 .
BA000008 Genomic DNA. Translation: BAA99059.1 .
AE009440 Genomic DNA. Translation: AAP98809.1 .
PIRi A86597.
E72027.
RefSeqi NP_225046.1. NC_000922.1.
NP_300908.1. NC_002491.1.
NP_445555.1. NC_002179.2.
NP_877152.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z755.
SMRi Q9Z755. Positions 8-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0851.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18989 ; AAD18989 ; CPn_0851 .
AAF73723 ; AAF73723 ; CP_1018 .
AAP98809 ; AAP98809 ; CpB0880 .
BAA99059 ; BAA99059 ; BAA99059 .
GeneIDi 1467559.
895150.
919614.
963494.
KEGGi cpa:CP1018.
cpj:CPj0851.
cpn:CPn0851.
cpt:CpB0880.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi QAVDERF.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci CPNE115711:GI7B-1053-MONOMER.
CPNE115713:GHEY-887-MONOMER.
CPNE138677:GH8N-879-MONOMER.
CPNE182082:GH4N-907-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiPCKG_CHLPN
AccessioniPrimary (citable) accession number: Q9Z755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3