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Q9Z755

- PCKG_CHLPN

UniProt

Q9Z755 - PCKG_CHLPN

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741SubstrateUniRule annotation
    Binding sitei216 – 2161Substrate; via amide nitrogenUniRule annotation
    Metal bindingi223 – 2231ManganeseUniRule annotation
    Binding sitei223 – 2231SubstrateUniRule annotation
    Metal bindingi243 – 2431Manganese; via tele nitrogenUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Active sitei267 – 2671UniRule annotation
    Metal bindingi290 – 2901ManganeseUniRule annotation
    Binding sitei381 – 3811GTPUniRule annotation
    Binding sitei412 – 4121GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi266 – 2716GTPUniRule annotation
    Nucleotide bindingi506 – 5094GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-1053-MONOMER.
    CPNE115713:GHEY-887-MONOMER.
    CPNE138677:GH8N-879-MONOMER.
    CPNE182082:GH4N-907-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:CPn_0851, CP_1018, CpB0880
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103598Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn0851.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z755.
    SMRiQ9Z755. Positions 8-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni379 – 3813Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiQAVDERF.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z755-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVWSTNIKHE GLKSWIDEVA KLTTPKDIRL CDGSDTEYDE LCTLMESTGT    50
    MIRLNPEFHP NCFLVRSSAD DVARVEQFTF ICTSTEAEAG PTNNWRDPQE 100
    MRRELHQLFR GCMQGRTLYI VPFCMGPLDS PFSIVGVELT DSPYVVCSMK 150
    IMTRMGDDVL RSLGTSGKFL KCLHSVGKPL SPGEADVSWP CNPKSMRIVH 200
    FQDDSSVMSF GSGYGGNALL GKKCVALRLA SYMAKSQGWL AEHMLIIGIT 250
    NPEGKKKYFS ASFPSACGKT NLAMLMPKLP GWKIECIGDD IAWIRPGRDG 300
    RLYAVNPEYG FFGVAPGTSE RTNPNALATC RSNSIFTNVA LTADGDVWWE 350
    GLTEQPPEPL TDWLGKPWKP GGSPAAHPNS RFTAPLRQCP SLDPEWNSPQ 400
    GVPLDAIIFG GRRSETIPLV YEALSWEHGV TIGAGMSSTT TAAIVGQLGK 450
    LRHDPFAMLP FCGYNMAYYF QHWLSFAENR SLKLPKIFGV NWFRKNNQGE 500
    FLWPGFSENL RVLEWIFQRT DGLEDIAERT PIGYLPNIQK FNLNGLNLDL 550
    QTVQELFSVD AEGWLAEVEN IGEYLKIFGS DCPQQITDEL LRIKSELKEK 600
    Length:600
    Mass (Da):66,992
    Last modified:May 1, 1999 - v1
    Checksum:i79590DC1A0A9932A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18989.1.
    AE002161 Genomic DNA. Translation: AAF73723.1.
    BA000008 Genomic DNA. Translation: BAA99059.1.
    AE009440 Genomic DNA. Translation: AAP98809.1.
    PIRiA86597.
    E72027.
    RefSeqiNP_225046.1. NC_000922.1.
    NP_300908.1. NC_002491.1.
    NP_445555.1. NC_002179.2.
    NP_877152.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18989; AAD18989; CPn_0851.
    AAF73723; AAF73723; CP_1018.
    AAP98809; AAP98809; CpB0880.
    BAA99059; BAA99059; BAA99059.
    GeneIDi1467559.
    895150.
    919614.
    963494.
    KEGGicpa:CP1018.
    cpj:CPj0851.
    cpn:CPn0851.
    cpt:CpB0880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18989.1 .
    AE002161 Genomic DNA. Translation: AAF73723.1 .
    BA000008 Genomic DNA. Translation: BAA99059.1 .
    AE009440 Genomic DNA. Translation: AAP98809.1 .
    PIRi A86597.
    E72027.
    RefSeqi NP_225046.1. NC_000922.1.
    NP_300908.1. NC_002491.1.
    NP_445555.1. NC_002179.2.
    NP_877152.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z755.
    SMRi Q9Z755. Positions 8-599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0851.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18989 ; AAD18989 ; CPn_0851 .
    AAF73723 ; AAF73723 ; CP_1018 .
    AAP98809 ; AAP98809 ; CpB0880 .
    BAA99059 ; BAA99059 ; BAA99059 .
    GeneIDi 1467559.
    895150.
    919614.
    963494.
    KEGGi cpa:CP1018.
    cpj:CPj0851.
    cpn:CPn0851.
    cpt:CpB0880.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi QAVDERF.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci CPNE115711:GI7B-1053-MONOMER.
    CPNE115713:GHEY-887-MONOMER.
    CPNE138677:GH8N-879-MONOMER.
    CPNE182082:GH4N-907-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiPCKG_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z755
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3