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Q9Z735 (RIBD_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Riboflavin biosynthesis protein RibD

Including the following 2 domains:

  1. Diaminohydroxyphosphoribosylaminopyrimidine deaminase
    Short name=DRAP deaminase
    EC=3.5.4.26
    Alternative name(s):
    Riboflavin-specific deaminase
  2. 5-amino-6-(5-phosphoribosylamino)uracil reductase
    EC=1.1.1.193
    Alternative name(s):
    HTP reductase
Gene names
Name:ribD
Synonyms:ribG
Ordered Locus Names:CPn_0871, CP_0998, CpB0900
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.

Catalytic activity

2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3.

5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH.

Cofactor

Binds 1 zinc ion By similarity.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.

Sequence similarities

In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

In the C-terminal section; belongs to the HTP reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Riboflavin biosynthesis protein RibD
PRO_0000171718

Regions

Nucleotide binding302 – 3087NADP By similarity
Region1 – 150150Deaminase
Region151 – 376226Reductase

Sites

Active site571Proton donor By similarity
Metal binding551Zinc; catalytic By similarity
Metal binding801Zinc; catalytic By similarity
Metal binding891Zinc; catalytic By similarity
Binding site1591NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site1731Substrate By similarity
Binding site1751NADP By similarity
Binding site1891Substrate By similarity
Binding site2011NADP By similarity
Binding site2051NADP By similarity
Binding site2091Substrate; via amide nitrogen By similarity
Binding site2121Substrate By similarity
Binding site2301NADP By similarity
Binding site3001Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z735 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A05F069E0F127B07

FASTA37641,209
        10         20         30         40         50         60 
MEDFSEQQLF FMRRAIEIGE KGRITAPPNP WVGCVVVQEN RIIGEGFHAY AGGPHAEELA 

        70         80         90        100        110        120 
IQNASMPISG SDVYVSLEPC SHFGSCPPCA NLLIKHKVSR VFVALVDPDP KVAGQGIAML 

       130        140        150        160        170        180 
RQAGIQVYVG IGESEAQASL QPYLYQRTHN FPWTILKSAA SVDGQVADSQ GKSQWITCPE 

       190        200        210        220        230        240 
ARHDVGKLRA ESQAILVGSR TVLSDDPWLT ARQPQGMLYP KQPLRVVLDS RGSVPPTSKV 

       250        260        270        280        290        300 
FDKTSPTLYV TTERCPENYI KVLDSLDVPV LLTESTPSGV DLHKVYEYLA QKKILQVLVE 

       310        320        330        340        350        360 
GGTTLHTSLL KERFVNSLVL YSGPMILGDQ KRPLVGVLGN LLESASPLTL KSSQILGNSL 

       370 
KVVWEISPQV FEPIRN

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001363 Genomic DNA. Translation: AAD19009.1.
AE002161 Genomic DNA. Translation: AAF38776.1.
BA000008 Genomic DNA. Translation: BAA99079.1.
AE009440 Genomic DNA. Translation: AAP98829.1.
PIRE86599.
G72026.
RefSeqNP_225066.1. NC_000922.1.
NP_300928.1. NC_002491.1.
NP_445535.1. NC_002179.2.
NP_877172.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z735.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1467579.
895231.
919634.
963471.
GenomeReviewsGene locus CPn_0871 in contig AE001363_GR.
Gene locus CP_0998 in contig AE002161_GR.
Gene locus CpB0900 in contig AE009440_GR.
Gene locus ribD in contig BA000008_GR.
KEGGcpa:CP0998.
cpn:CPn0871.
cpt:CpB0900.
TIGRCP_0998.

Phylogenomic databases

HOGENOMHBG668075.
OMAGWHERAG.
ProtClustDBCLSK871565.

Enzyme and pathway databases

BioCycCPNE115711:CP_0998-MONOMER.
CPNE115713:CPN0871-MONOMER.
CPNE138677:CPJ0871-MONOMER.
CPNE182082:CPB0900-MONOMER.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR024072. DHFR-like_dom.
IPR004794. Eubact_RibD.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
Gene3DG3DSA:3.40.430.10. G3DSA:3.40.430.10. 1 hit.
KOK11752.
PANTHERPTHR11079:SF10. Eubact_ribD. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF01872. RibD_C. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF53597. SSF53597. 1 hit.
TIGRFAMsTIGR00326. Eubact_ribD. 1 hit.
TIGR00227. RibD_Cterm. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIBD_CHLPN
AccessionPrimary (citable) accession number: Q9Z735
Secondary accession number(s): Q9JQ54
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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