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Protein

Na(+)-translocating NADH-quinone reductase subunit F

Gene

nqrF

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.UniRule annotation

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi82Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi85Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi117Iron-sulfur (2Fe-2S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIon transport, Sodium transport, Transport
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD, Sodium, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit FUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit FUniRule annotation
Short name:
Na(+)-translocating NQR subunit FUniRule annotation
Alternative name(s):
NQR complex subunit FUniRule annotation
NQR-1 subunit FUniRule annotation
Gene namesi
Name:nqrFUniRule annotation
Synonyms:nqr6
Ordered Locus Names:CPn_0883, CP_0983, CpB0912
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000744911 – 431Na(+)-translocating NADH-quinone reductase subunit FAdd BLAST431

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0912

Structurei

3D structure databases

ProteinModelPortaliQ9Z723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 1332Fe-2S ferredoxin-typeUniRule annotationAdd BLAST95
Domaini136 – 286FAD-binding FR-typeUniRule annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni289 – 413CatalyticAdd BLAST125

Sequence similaritiesi

Belongs to the NqrF family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RKJ Bacteria
COG2871 LUCA
HOGENOMiHOG000263661
KOiK00351
OMAiYWYGGRS
OrthoDBiPOG091H05VQ

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
HAMAPiMF_00430 NqrF, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR012675 Beta-grasp_dom_sf
IPR017927 Fd_Rdtase_FAD-bd
IPR010205 NqrF
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000044 Cis_Diol_DH_RD, 1 hit
SUPFAMiSSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 2 hits
TIGRFAMsiTIGR01941 nqrF, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWLSGLYFI CIASLIFCAI GVILAGVILL SRKLFIKVHP CKLKINDNEE
60 70 80 90 100
LTKTVESGQT LLVSLLSSGI PIPSPCGGKA TCKQCKVRVV KNADEPLETD
110 120 130 140 150
RSTFSKRQLE EGWRLSCQCK VQHDMSLEIE ERYLNASSWE GTVISNDNVA
160 170 180 190 200
TFIKELVVAV DPNKPIPFKP GGYLQITVPS YKTNSSDWKQ TMAPEYYSDW
210 220 230 240 250
EHFHLFDQVI DNSQLPADSA NKAYSLASYP AELPTIKFNI RIATPPFING
260 270 280 290 300
KPNSEIPWGV CSSYVFSLKP GDKITVSGPY GESFMKDDDR PLIFLIGGAG
310 320 330 340 350
SSFGRSHILD LLLNKHSKRE IDLWYGARSL KENIYQEEYE NLERQFPNFH
360 370 380 390 400
YHLVLSEPLP EDIAAGWDKD DPTKTNFLFR AFNLGQLSRL DNPEDYLYYV
410 420 430
CGPPLHNSSI LKLLGDYGVE RSSIILDDFG S
Length:431
Mass (Da):48,500
Last modified:May 1, 1999 - v1
Checksum:iD6D9A7A474C62708
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → P in BAA99091 (PubMed:10871362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19021.1
AE002161 Genomic DNA Translation: AAF38762.1
BA000008 Genomic DNA Translation: BAA99091.1
AE009440 Genomic DNA Translation: AAP98841.1
PIRiA86601
G72022
RefSeqiNP_225078.1, NC_000922.1
WP_010883518.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19021; AAD19021; CPn_0883
AAF38762; AAF38762; CP_0983
AAP98841; AAP98841; CpB0912
BAA99091; BAA99091; BAA99091
GeneIDi895388
KEGGicpa:CP_0983
cpj:nqr6
cpn:CPn0883
cpt:CpB0912
PATRICifig|115713.3.peg.964

Similar proteinsi

Entry informationi

Entry nameiNQRF_CHLPN
AccessioniPrimary (citable) accession number: Q9Z723
Secondary accession number(s): Q9JS95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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