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Q9Z701

- MUDD_CHLPN

UniProt

Q9Z701 - MUDD_CHLPN

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Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi738 – 7381Magnesium or manganese 1By similarity
Metal bindingi751 – 7511Magnesium or manganese 1By similarity
Metal bindingi751 – 7511Magnesium or manganese 2By similarity
Metal bindingi753 – 7531Magnesium or manganese 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1177ATPSequence Analysis
Nucleotide bindingi606 – 66156ATPBy similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-991-MONOMER.
CPNE115713:GHEY-946-MONOMER.
CPNE138677:GH8N-938-MONOMER.
CPNE182082:GH4N-969-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme MurC/Ddl
Including the following 2 domains:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:murC/ddl
Ordered Locus Names:CPn_0905, CP_0961, CpB0937
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Bifunctional enzyme MurC/DdlPRO_0000177915Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0905.

Structurei

3D structure databases

ProteinModelPortaliQ9Z701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini573 – 784212ATP-graspAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 450450UDP-N-acetylmuramate--alanine ligaseAdd
BLAST
Regioni451 – 809359D-alanine--D-alanine ligaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the MurCDEF family.Curated
In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated
Contains 1 ATP-grasp domain.Curated

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000034913.
KOiK01921.
K01924.
OMAiRIDFFLD.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z701-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGTPQYHFI GIGGIGMSAL AHILLDRGYE VSGSDLYESY TIESLKAKGA
60 70 80 90 100
RCFSGHDSSH VPHDAVVVYS SSIAPDNVEY LTAIQRSSRL LHRAELLSQL
110 120 130 140 150
MEGYESILVS GSHGKTGTSS LIRAIFQEAQ KDPSYAIGGL AANCLNGYSG
160 170 180 190 200
SSKIFVAEAD ESDGSLKHYT PRAVVITNID NEHLNNYAGN LDNLVQVIQD
210 220 230 240 250
FSRKVTDLNK VFYNGDCPIL KGNVQGISYG YSPECQLHIV SYNQKAWQSH
260 270 280 290 300
FSFTFLGQEY QDIELNLPGQ HNAANAAAAC GVALTFGIDI NIIRKALKKF
310 320 330 340 350
SGVHRRLERK NISESFLFLE DYAHHPVEVA HTLRSVRDAV GLRRVIAIFQ
360 370 380 390 400
PHRFSRLEEC LQTFPKAFQE ADEVILTDVY SAGESPRESI ILSDLAEQIR
410 420 430 440 450
KSSYVHCCYV PHGDIVDYLR NYIRIHDVCV SLGAGNIYTI GEALKDFNPK
460 470 480 490 500
KLSIGLVCGG KSCEHDISLL SAQHVSKYIS PEFYDVSYFI INRQGLWRTG
510 520 530 540 550
KDFPHLIEET QGDSPLSSEI ASALAKVDCL FPVLHGPFGE DGTIQGFFEI
560 570 580 590 600
LGKPYAGPSL SLAATAMDKL LTKRIASAVG VPVVPYQPLN LCFWKRNPEL
610 620 630 640 650
CIQNLIETFS FPMIVKTAHL GSSIGIFLVR DKEELQEKIS EAFLYDTDVF
660 670 680 690 700
VEESRLGSRE IEVSCIGHSS SWYCMAGPNE RCGASGFIDY QEKYGFDGID
710 720 730 740 750
CAKISFDLQL SQESLDCVRE LAERVYRAMQ GKGSARIDFF LDEEGNYWLS
760 770 780 790 800
EVNPIPGMTA ASPFLQAFVH AGWTQEQIVD HFIIDALHKF DKQQTIEQAF

TKEQDLVKR
Length:809
Mass (Da):89,964
Last modified:May 1, 1999 - v1
Checksum:i1A204C6B20E03B47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti560 – 5601L → P in AAP98866. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19043.1.
AE002161 Genomic DNA. Translation: AAF38741.1.
BA000008 Genomic DNA. Translation: BAA99113.1.
AE009440 Genomic DNA. Translation: AAP98866.1.
PIRiD72022.
G86603.
RefSeqiNP_225100.1. NC_000922.1.
NP_300962.1. NC_002491.1.
NP_445498.1. NC_002179.2.
NP_877209.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19043; AAD19043; CPn_0905.
AAF38741; AAF38741; CP_0961.
AAP98866; AAP98866; CpB0937.
BAA99113; BAA99113; BAA99113.
GeneIDi1467616.
895305.
919670.
963426.
KEGGicpa:CP0961.
cpj:CPj0905.
cpn:CPn0905.
cpt:CpB0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19043.1 .
AE002161 Genomic DNA. Translation: AAF38741.1 .
BA000008 Genomic DNA. Translation: BAA99113.1 .
AE009440 Genomic DNA. Translation: AAP98866.1 .
PIRi D72022.
G86603.
RefSeqi NP_225100.1. NC_000922.1.
NP_300962.1. NC_002491.1.
NP_445498.1. NC_002179.2.
NP_877209.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z701.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19043 ; AAD19043 ; CPn_0905 .
AAF38741 ; AAF38741 ; CP_0961 .
AAP98866 ; AAP98866 ; CpB0937 .
BAA99113 ; BAA99113 ; BAA99113 .
GeneIDi 1467616.
895305.
919670.
963426.
KEGGi cpa:CP0961.
cpj:CPj0905.
cpn:CPn0905.
cpt:CpB0937.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000034913.
KOi K01921.
K01924.
OMAi RIDFFLD.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CPNE115711:GI7B-991-MONOMER.
CPNE115713:GHEY-946-MONOMER.
CPNE138677:GH8N-938-MONOMER.
CPNE182082:GH4N-969-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiMUDD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z701
Secondary accession number(s): Q9JQB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3