Reviewed,
UniProtKB/Swiss-Prot Q9Z701 (MUDD_CHLPN)
Last modified
February 9, 2010.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional enzyme murC/ddl Including the following 2 domains: 1- Recommended name: UDP-N-acetylmuramate--L-alanine ligase EC=6.3.2.8 Alternative name(s): UDP-N-acetylmuramoyl-L-alanine synthetase 2- Recommended name: D-alanine--D-alanine ligase EC=6.3.2.4 Alternative name(s): D-alanylalanine synthetase D-Ala-D-Ala ligase | ||||
| Gene names |
| ||||
| Organism | Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83558 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila |
Protein attributes
| Sequence length | 809 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation. HAMAP MF_00046 |
| Catalytic activity | ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046 ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00046 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP MF_00046 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00046. |
| Sequence similarities | In the N-terminal section; belongs to the murCDEF family. In the C-terminal section; belongs to the D-alanine--D-alanine ligase family. Contains 1 ATP-grasp domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 809 | 809 | Bifunctional enzyme murC/ddl HAMAP MF_00046 | PRO_0000177915 | |||||
Regions | |||||||||
| Domain | 573 – 784 | 212 | ATP-grasp | ||||||
| Nucleotide binding | 111 – 117 | 7 | ATP Potential | ||||||
| Nucleotide binding | 606 – 661 | 56 | ATP By similarity | ||||||
| Region | 1 – 450 | 450 | UDP-N-acetylmuramate--alanine ligase HAMAP MF_00046 | ||||||
| Region | 451 – 809 | 359 | D-alanine--D-alanine ligase HAMAP MF_00046 | ||||||
Sites | |||||||||
| Metal binding | 738 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 751 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 751 | 1 | Magnesium or manganese 2 By similarity | ||||||
| Metal binding | 753 | 1 | Magnesium or manganese 2 By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 560 | 1 | L → P in AAP98866. Ref.4 | ||||||
Sequences
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References
| [1] | "Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029. |
| [2] | "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. Fraser C.M.Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39. |
| [3] | "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138. |
| [4] | "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001363 Genomic DNA. Translation: AAD19043.1. AE002161 Genomic DNA. Translation: AAF38741.1. BA000008 Genomic DNA. Translation: BAA99113.1. AE009440 Genomic DNA. Translation: AAP98866.1. |
| PIR | D72022. G86603. |
| RefSeq | NP_225100.1. NP_300962.1. NP_445498.1. NP_877209.1. |
3D structure databases | |
| SMR | Q9Z701. Positions 6-446, 451-796. |
| ModBase | Search... |
2-D gel databases | |
| PHCI-2DPAGE | Q9Z701. |
Genome annotation databases | |
| GeneID | 1467616. 895305. 919670. 963426. |
| GenomeReviews | Gene locus CPn_0905 in contig AE001363_GR. Gene locus CP_0961 in contig AE002161_GR. Gene locus CpB0937 in contig AE009440_GR. Gene locus murC/ddl in contig BA000008_GR. |
| KEGG | cpa:CP0961. cpn:CPn0905. cpt:CpB0937. |
| TIGR | CP_0961. |
Phylogenomic databases | |
| HOGENOM | HBG413852. |
| OMA | RRMERKN. |
| PhylomeDB | Q9Z701. |
Enzyme and pathway databases | |
| BioCyc | CPNE115711:CP_0961-MONOMER. CPNE115713:CPN0905-MONOMER. CPNE138677:CPJ0905-MONOMER. CPNE182082:CPB0937-MONOMER. |
| BRENDA | 6.3.2.4. 264832. 6.3.2.8. 264832. |
Family and domain databases | |
| HAMAP | MF_00046. MurC. Fused. [Tree] MF_00047. Dala_Dala_lig. Fused. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 1 hit. PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01205. D_ala_D_alaTIGR. 1 hit. TIGR01082. murC. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MUDD_CHLPN | ||||||||
| Accession | Primary (citable) accession number: Q9Z701 Secondary accession number(s): Q9JQB5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


