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Q9Z701

- MUDD_CHLPN

UniProt

Q9Z701 - MUDD_CHLPN

Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cell wall formation.By similarity

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi738 – 7381Magnesium or manganese 1By similarity
    Metal bindingi751 – 7511Magnesium or manganese 1By similarity
    Metal bindingi751 – 7511Magnesium or manganese 2By similarity
    Metal bindingi753 – 7531Magnesium or manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi111 – 1177ATPSequence Analysis
    Nucleotide bindingi606 – 66156ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-991-MONOMER.
    CPNE115713:GHEY-946-MONOMER.
    CPNE138677:GH8N-938-MONOMER.
    CPNE182082:GH4N-969-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional enzyme MurC/Ddl
    Including the following 2 domains:
    UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
    D-alanine--D-alanine ligase (EC:6.3.2.4)
    Alternative name(s):
    D-Ala-D-Ala ligase
    D-alanylalanine synthetase
    Gene namesi
    Name:murC/ddl
    Ordered Locus Names:CPn_0905, CP_0961, CpB0937
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 809809Bifunctional enzyme MurC/DdlPRO_0000177915Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0905.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z701.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini573 – 784212ATP-graspAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 450450UDP-N-acetylmuramate--alanine ligaseAdd
    BLAST
    Regioni451 – 809359D-alanine--D-alanine ligaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the MurCDEF family.Curated
    In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated
    Contains 1 ATP-grasp domain.Curated

    Phylogenomic databases

    eggNOGiCOG1181.
    HOGENOMiHOG000034913.
    KOiK01921.
    K01924.
    OMAiRIDFFLD.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z701-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGTPQYHFI GIGGIGMSAL AHILLDRGYE VSGSDLYESY TIESLKAKGA    50
    RCFSGHDSSH VPHDAVVVYS SSIAPDNVEY LTAIQRSSRL LHRAELLSQL 100
    MEGYESILVS GSHGKTGTSS LIRAIFQEAQ KDPSYAIGGL AANCLNGYSG 150
    SSKIFVAEAD ESDGSLKHYT PRAVVITNID NEHLNNYAGN LDNLVQVIQD 200
    FSRKVTDLNK VFYNGDCPIL KGNVQGISYG YSPECQLHIV SYNQKAWQSH 250
    FSFTFLGQEY QDIELNLPGQ HNAANAAAAC GVALTFGIDI NIIRKALKKF 300
    SGVHRRLERK NISESFLFLE DYAHHPVEVA HTLRSVRDAV GLRRVIAIFQ 350
    PHRFSRLEEC LQTFPKAFQE ADEVILTDVY SAGESPRESI ILSDLAEQIR 400
    KSSYVHCCYV PHGDIVDYLR NYIRIHDVCV SLGAGNIYTI GEALKDFNPK 450
    KLSIGLVCGG KSCEHDISLL SAQHVSKYIS PEFYDVSYFI INRQGLWRTG 500
    KDFPHLIEET QGDSPLSSEI ASALAKVDCL FPVLHGPFGE DGTIQGFFEI 550
    LGKPYAGPSL SLAATAMDKL LTKRIASAVG VPVVPYQPLN LCFWKRNPEL 600
    CIQNLIETFS FPMIVKTAHL GSSIGIFLVR DKEELQEKIS EAFLYDTDVF 650
    VEESRLGSRE IEVSCIGHSS SWYCMAGPNE RCGASGFIDY QEKYGFDGID 700
    CAKISFDLQL SQESLDCVRE LAERVYRAMQ GKGSARIDFF LDEEGNYWLS 750
    EVNPIPGMTA ASPFLQAFVH AGWTQEQIVD HFIIDALHKF DKQQTIEQAF 800
    TKEQDLVKR 809
    Length:809
    Mass (Da):89,964
    Last modified:May 1, 1999 - v1
    Checksum:i1A204C6B20E03B47
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti560 – 5601L → P in AAP98866. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19043.1.
    AE002161 Genomic DNA. Translation: AAF38741.1.
    BA000008 Genomic DNA. Translation: BAA99113.1.
    AE009440 Genomic DNA. Translation: AAP98866.1.
    PIRiD72022.
    G86603.
    RefSeqiNP_225100.1. NC_000922.1.
    NP_300962.1. NC_002491.1.
    NP_445498.1. NC_002179.2.
    NP_877209.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19043; AAD19043; CPn_0905.
    AAF38741; AAF38741; CP_0961.
    AAP98866; AAP98866; CpB0937.
    BAA99113; BAA99113; BAA99113.
    GeneIDi1467616.
    895305.
    919670.
    963426.
    KEGGicpa:CP0961.
    cpj:CPj0905.
    cpn:CPn0905.
    cpt:CpB0937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19043.1 .
    AE002161 Genomic DNA. Translation: AAF38741.1 .
    BA000008 Genomic DNA. Translation: BAA99113.1 .
    AE009440 Genomic DNA. Translation: AAP98866.1 .
    PIRi D72022.
    G86603.
    RefSeqi NP_225100.1. NC_000922.1.
    NP_300962.1. NC_002491.1.
    NP_445498.1. NC_002179.2.
    NP_877209.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z701.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0905.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19043 ; AAD19043 ; CPn_0905 .
    AAF38741 ; AAF38741 ; CP_0961 .
    AAP98866 ; AAP98866 ; CpB0937 .
    BAA99113 ; BAA99113 ; BAA99113 .
    GeneIDi 1467616.
    895305.
    919670.
    963426.
    KEGGi cpa:CP0961.
    cpj:CPj0905.
    cpn:CPn0905.
    cpt:CpB0937.

    Phylogenomic databases

    eggNOGi COG1181.
    HOGENOMi HOG000034913.
    KOi K01921.
    K01924.
    OMAi RIDFFLD.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CPNE115711:GI7B-991-MONOMER.
    CPNE115713:GHEY-946-MONOMER.
    CPNE138677:GH8N-938-MONOMER.
    CPNE182082:GH4N-969-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiMUDD_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z701
    Secondary accession number(s): Q9JQB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3