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Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine.
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi738Magnesium or manganese 1By similarity1
Metal bindingi751Magnesium or manganese 1By similarity1
Metal bindingi751Magnesium or manganese 2By similarity1
Metal bindingi753Magnesium or manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 117ATPSequence analysis7
Nucleotide bindingi606 – 661ATPBy similarityAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme MurC/Ddl
Including the following 2 domains:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:murC/ddl
Ordered Locus Names:CPn_0905, CP_0961, CpB0937
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779151 – 809Bifunctional enzyme MurC/DdlAdd BLAST809

Proteomic databases

PRIDEiQ9Z701

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0937

Structurei

3D structure databases

ProteinModelPortaliQ9Z701
SMRiQ9Z701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini573 – 784ATP-graspAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 450UDP-N-acetylmuramate--alanine ligaseAdd BLAST450
Regioni451 – 809D-alanine--D-alanine ligaseAdd BLAST359

Sequence similaritiesi

In the N-terminal section; belongs to the MurCDEF family.Curated
In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated

Phylogenomic databases

eggNOGiENOG4105DFU Bacteria
COG0773 LUCA
COG1181 LUCA
HOGENOMiHOG000034913
KOiK01921
K01924
OMAiINRQGLW
OrthoDBiPOG091H02MF

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
MF_00046 MurC, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
IPR016185 PreATP-grasp_dom_sf
IPR005758 UDP-N-AcMur_Ala_ligase_murC
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
SSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
TIGR01082 murC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGTPQYHFI GIGGIGMSAL AHILLDRGYE VSGSDLYESY TIESLKAKGA
60 70 80 90 100
RCFSGHDSSH VPHDAVVVYS SSIAPDNVEY LTAIQRSSRL LHRAELLSQL
110 120 130 140 150
MEGYESILVS GSHGKTGTSS LIRAIFQEAQ KDPSYAIGGL AANCLNGYSG
160 170 180 190 200
SSKIFVAEAD ESDGSLKHYT PRAVVITNID NEHLNNYAGN LDNLVQVIQD
210 220 230 240 250
FSRKVTDLNK VFYNGDCPIL KGNVQGISYG YSPECQLHIV SYNQKAWQSH
260 270 280 290 300
FSFTFLGQEY QDIELNLPGQ HNAANAAAAC GVALTFGIDI NIIRKALKKF
310 320 330 340 350
SGVHRRLERK NISESFLFLE DYAHHPVEVA HTLRSVRDAV GLRRVIAIFQ
360 370 380 390 400
PHRFSRLEEC LQTFPKAFQE ADEVILTDVY SAGESPRESI ILSDLAEQIR
410 420 430 440 450
KSSYVHCCYV PHGDIVDYLR NYIRIHDVCV SLGAGNIYTI GEALKDFNPK
460 470 480 490 500
KLSIGLVCGG KSCEHDISLL SAQHVSKYIS PEFYDVSYFI INRQGLWRTG
510 520 530 540 550
KDFPHLIEET QGDSPLSSEI ASALAKVDCL FPVLHGPFGE DGTIQGFFEI
560 570 580 590 600
LGKPYAGPSL SLAATAMDKL LTKRIASAVG VPVVPYQPLN LCFWKRNPEL
610 620 630 640 650
CIQNLIETFS FPMIVKTAHL GSSIGIFLVR DKEELQEKIS EAFLYDTDVF
660 670 680 690 700
VEESRLGSRE IEVSCIGHSS SWYCMAGPNE RCGASGFIDY QEKYGFDGID
710 720 730 740 750
CAKISFDLQL SQESLDCVRE LAERVYRAMQ GKGSARIDFF LDEEGNYWLS
760 770 780 790 800
EVNPIPGMTA ASPFLQAFVH AGWTQEQIVD HFIIDALHKF DKQQTIEQAF

TKEQDLVKR
Length:809
Mass (Da):89,964
Last modified:May 1, 1999 - v1
Checksum:i1A204C6B20E03B47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti560L → P in AAP98866 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19043.1
AE002161 Genomic DNA Translation: AAF38741.1
BA000008 Genomic DNA Translation: BAA99113.1
AE009440 Genomic DNA Translation: AAP98866.1
PIRiD72022
G86603
RefSeqiNP_225100.1, NC_000922.1
WP_010883540.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19043; AAD19043; CPn_0905
AAF38741; AAF38741; CP_0961
AAP98866; AAP98866; CpB0937
BAA99113; BAA99113; BAA99113
GeneIDi895305
KEGGicpa:CP_0961
cpj:murC_ddlA
cpn:CPn0905
cpt:CpB0937
PATRICifig|115713.3.peg.986

Similar proteinsi

Entry informationi

Entry nameiMUDD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z701
Secondary accession number(s): Q9JQB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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