ID   LPXB_CHLPN              Reviewed;         604 AA.
AC   Q9Z6U3;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=Lipid-A-disaccharide synthase;
DE            EC=2.4.1.182;
GN   Name=lpxB; OrderedLocusNames=CPn_0965, CP_0895, CpB1002;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC       diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor
CC       of lipid A, a phosphorylated glycolipid that anchors the
CC       lipopolysaccharide to the outer membrane of the cell. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-
CC         glucosamine = a lipid A disaccharide + H(+) + UDP;
CC         Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343;
CC         EC=2.4.1.182;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the LpxB family.
CC       {ECO:0000305}.
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DR   EMBL; AE001363; AAD19101.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38682.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA99173.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98931.1; -; Genomic_DNA.
DR   PIR; B72014; B72014.
DR   PIR; C86611; C86611.
DR   RefSeq; NP_225158.1; NC_000922.1.
DR   RefSeq; WP_010883598.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z6U3; -.
DR   SMR; Q9Z6U3; -.
DR   STRING; 406984.CPK_ORF00380; -.
DR   GeneID; 45051022; -.
DR   KEGG; cpa:CP_0895; -.
DR   KEGG; cpj:lpxB; -.
DR   KEGG; cpn:CPn_0965; -.
DR   KEGG; cpt:CpB1002; -.
DR   PATRIC; fig|115713.3.peg.1056; -.
DR   eggNOG; COG0763; Bacteria.
DR   eggNOG; COG3952; Bacteria.
DR   HOGENOM; CLU_430672_0_0_0; -.
DR   OrthoDB; 9801642at2; -.
DR   UniPathway; UPA00973; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1280.290; -; 1.
DR   HAMAP; MF_00392; LpxB; 1.
DR   InterPro; IPR003835; Glyco_trans_19.
DR   InterPro; IPR011499; Lipid_A_biosynth_N.
DR   NCBIfam; TIGR00215; lpxB; 1.
DR   PANTHER; PTHR30372; LIPID-A-DISACCHARIDE SYNTHASE; 1.
DR   PANTHER; PTHR30372:SF7; LIPID-A-DISACCHARIDE SYNTHASE; 1.
DR   Pfam; PF07578; LAB_N; 2.
DR   Pfam; PF02684; LpxB; 1.
DR   SMART; SM01259; LAB_N; 2.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis;
KW   Lipid metabolism; Transferase.
FT   CHAIN           1..604
FT                   /note="Lipid-A-disaccharide synthase"
FT                   /id="PRO_0000190160"
FT   REGION          1..220
FT                   /note="Unknown"
FT   REGION          221..604
FT                   /note="Lipid-A-disaccharide synthase"
SQ   SEQUENCE   604 AA;  69014 MW;  094BF1B7013E07C8 CRC64;
     MIPSGLVYLL YPLGFLASLF FGSAFSIQWW LSKKRKEVYA PRSFWILSSI GATLMIVHGT
     IQSQFPVTVL HVINLIIYLR NLNITSSRPI SFRATLVLMA LSVVFVTLPF LYVNMEWMAS
     PNIFHLPLPP AQLSWHLIGC LGLAIFSGRF LIQWFYIESN NTKDFPLLFW KIGLLGGLLA
     LVYFIRIGDP INILCYGCGL FPSIANLRLF YKEQRSTPYL DTHCFLSAGE ASGDILGGKL
     IQSIKSLYPN IRFWGVGGPA MRQEGLQPIL NMEEFQVSGF AEVLGSLFRL YRNYRKILKT
     ILKHKPATLI FIDFPDFHLL LIKKLRKHGY RGKIIHYVCP SIWAWRPKRK RILEQHLDML
     LLILPFEEGL FKNTSLETVY LGHPLVEEIS DYKEQASWKE KFLNSDRPIV AAFPGSRRGD
     ISRNLRIQVQ AFLNSSLSQT HQFVVSSSSA KYDEIIEDTL KAEGCQHSQI IPMNFRYELM
     RSCDCALAKC GTIVLETALN QTPTIVMCRL RPFDTFLAKY IFKILLPAYS LPNIIMNSVI
     FPEFIGGKKD FHPEEIATAL DLLNQHGSKE KQKEDCRKLC KVMTTGQIAS EEFLKRIFDT
     LPAV
//