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Q9Z6U3

- LPXB_CHLPN

UniProt

Q9Z6U3 - LPXB_CHLPN

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, CPn_0965, CP_0895, CpB1002
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-924-MONOMER.
CPNE115713:GHEY-1007-MONOMER.
CPNE138677:GH8N-999-MONOMER.
CPNE182082:GH4N-1035-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CPn_0965, CP_0895, CpB1002
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Lipid-A-disaccharide synthaseUniRule annotationPRO_0000190160Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0965.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6U3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 220220UnknownUniRule annotationAdd
BLAST
Regioni221 – 604384Lipid-A-disaccharide synthaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6U3-1 [UniParc]FASTAAdd to Basket

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MIPSGLVYLL YPLGFLASLF FGSAFSIQWW LSKKRKEVYA PRSFWILSSI    50
GATLMIVHGT IQSQFPVTVL HVINLIIYLR NLNITSSRPI SFRATLVLMA 100
LSVVFVTLPF LYVNMEWMAS PNIFHLPLPP AQLSWHLIGC LGLAIFSGRF 150
LIQWFYIESN NTKDFPLLFW KIGLLGGLLA LVYFIRIGDP INILCYGCGL 200
FPSIANLRLF YKEQRSTPYL DTHCFLSAGE ASGDILGGKL IQSIKSLYPN 250
IRFWGVGGPA MRQEGLQPIL NMEEFQVSGF AEVLGSLFRL YRNYRKILKT 300
ILKHKPATLI FIDFPDFHLL LIKKLRKHGY RGKIIHYVCP SIWAWRPKRK 350
RILEQHLDML LLILPFEEGL FKNTSLETVY LGHPLVEEIS DYKEQASWKE 400
KFLNSDRPIV AAFPGSRRGD ISRNLRIQVQ AFLNSSLSQT HQFVVSSSSA 450
KYDEIIEDTL KAEGCQHSQI IPMNFRYELM RSCDCALAKC GTIVLETALN 500
QTPTIVMCRL RPFDTFLAKY IFKILLPAYS LPNIIMNSVI FPEFIGGKKD 550
FHPEEIATAL DLLNQHGSKE KQKEDCRKLC KVMTTGQIAS EEFLKRIFDT 600
LPAV 604
Length:604
Mass (Da):69,014
Last modified:May 1, 1999 - v1
Checksum:i094BF1B7013E07C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19101.1.
AE002161 Genomic DNA. Translation: AAF38682.1.
BA000008 Genomic DNA. Translation: BAA99173.1.
AE009440 Genomic DNA. Translation: AAP98931.1.
PIRiB72014.
C86611.
RefSeqiNP_225158.1. NC_000922.1.
NP_301022.1. NC_002491.1.
NP_445433.1. NC_002179.2.
NP_877274.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19101; AAD19101; CPn_0965.
AAF38682; AAF38682; CP_0895.
AAP98931; AAP98931; CpB1002.
BAA99173; BAA99173; BAA99173.
GeneIDi1467681.
895627.
919726.
963352.
KEGGicpa:CP0895.
cpj:CPj0965.
cpn:CPn0965.
cpt:CpB1002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19101.1 .
AE002161 Genomic DNA. Translation: AAF38682.1 .
BA000008 Genomic DNA. Translation: BAA99173.1 .
AE009440 Genomic DNA. Translation: AAP98931.1 .
PIRi B72014.
C86611.
RefSeqi NP_225158.1. NC_000922.1.
NP_301022.1. NC_002491.1.
NP_445433.1. NC_002179.2.
NP_877274.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6U3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0965.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19101 ; AAD19101 ; CPn_0965 .
AAF38682 ; AAF38682 ; CP_0895 .
AAP98931 ; AAP98931 ; CpB1002 .
BAA99173 ; BAA99173 ; BAA99173 .
GeneIDi 1467681.
895627.
919726.
963352.
KEGGi cpa:CP0895.
cpj:CPj0965.
cpn:CPn0965.
cpt:CpB1002.

Phylogenomic databases

eggNOGi COG3952.
HOGENOMi HOG000034725.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CPNE115711:GI7B-924-MONOMER.
CPNE115713:GHEY-1007-MONOMER.
CPNE138677:GH8N-999-MONOMER.
CPNE182082:GH4N-1035-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiLPXB_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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