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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC), UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC), UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK), Tetraacyldisaccharide 4'-kinase (lpxK), Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CPn_0965, CP_0895, CpB1002
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001901601 – 604Lipid-A-disaccharide synthaseAdd BLAST604

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB1002

Structurei

3D structure databases

ProteinModelPortaliQ9Z6U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 220UnknownAdd BLAST220
Regioni221 – 604Lipid-A-disaccharide synthaseAdd BLAST384

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
COG3952 LUCA
HOGENOMiHOG000034725
KOiK00748
OMAiKIIHYVC
OrthoDBiPOG091H01NW

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
IPR011499 Lipid_A_biosynth_N
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF07578 LAB_N, 2 hits
PF02684 LpxB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD339292 LAB_N, 2 hits
SMARTiView protein in SMART
SM01259 LAB_N, 2 hits
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z6U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPSGLVYLL YPLGFLASLF FGSAFSIQWW LSKKRKEVYA PRSFWILSSI
60 70 80 90 100
GATLMIVHGT IQSQFPVTVL HVINLIIYLR NLNITSSRPI SFRATLVLMA
110 120 130 140 150
LSVVFVTLPF LYVNMEWMAS PNIFHLPLPP AQLSWHLIGC LGLAIFSGRF
160 170 180 190 200
LIQWFYIESN NTKDFPLLFW KIGLLGGLLA LVYFIRIGDP INILCYGCGL
210 220 230 240 250
FPSIANLRLF YKEQRSTPYL DTHCFLSAGE ASGDILGGKL IQSIKSLYPN
260 270 280 290 300
IRFWGVGGPA MRQEGLQPIL NMEEFQVSGF AEVLGSLFRL YRNYRKILKT
310 320 330 340 350
ILKHKPATLI FIDFPDFHLL LIKKLRKHGY RGKIIHYVCP SIWAWRPKRK
360 370 380 390 400
RILEQHLDML LLILPFEEGL FKNTSLETVY LGHPLVEEIS DYKEQASWKE
410 420 430 440 450
KFLNSDRPIV AAFPGSRRGD ISRNLRIQVQ AFLNSSLSQT HQFVVSSSSA
460 470 480 490 500
KYDEIIEDTL KAEGCQHSQI IPMNFRYELM RSCDCALAKC GTIVLETALN
510 520 530 540 550
QTPTIVMCRL RPFDTFLAKY IFKILLPAYS LPNIIMNSVI FPEFIGGKKD
560 570 580 590 600
FHPEEIATAL DLLNQHGSKE KQKEDCRKLC KVMTTGQIAS EEFLKRIFDT

LPAV
Length:604
Mass (Da):69,014
Last modified:May 1, 1999 - v1
Checksum:i094BF1B7013E07C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19101.1
AE002161 Genomic DNA Translation: AAF38682.1
BA000008 Genomic DNA Translation: BAA99173.1
AE009440 Genomic DNA Translation: AAP98931.1
PIRiB72014
C86611
RefSeqiNP_225158.1, NC_000922.1
WP_010883598.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19101; AAD19101; CPn_0965
AAF38682; AAF38682; CP_0895
AAP98931; AAP98931; CpB1002
BAA99173; BAA99173; BAA99173
GeneIDi895627
KEGGicpa:CP_0895
cpj:lpxB
cpn:CPn0965
cpt:CpB1002
PATRICifig|115713.3.peg.1056

Similar proteinsi

Entry informationi

Entry nameiLPXB_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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