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Q9Z6U3

- LPXB_CHLPN

UniProt

Q9Z6U3 - LPXB_CHLPN

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-924-MONOMER.
    CPNE115713:GHEY-1007-MONOMER.
    CPNE138677:GH8N-999-MONOMER.
    CPNE182082:GH4N-1035-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:CPn_0965, CP_0895, CpB1002
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 604604Lipid-A-disaccharide synthasePRO_0000190160Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0965.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z6U3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 220220UnknownAdd
    BLAST
    Regioni221 – 604384Lipid-A-disaccharide synthaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG3952.
    HOGENOMiHOG000034725.
    KOiK00748.
    OMAiKIIHYVC.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view]
    PfamiPF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view]
    ProDomiPD339292. LAB_N. 2 hits.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z6U3-1 [UniParc]FASTAAdd to Basket

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    MIPSGLVYLL YPLGFLASLF FGSAFSIQWW LSKKRKEVYA PRSFWILSSI    50
    GATLMIVHGT IQSQFPVTVL HVINLIIYLR NLNITSSRPI SFRATLVLMA 100
    LSVVFVTLPF LYVNMEWMAS PNIFHLPLPP AQLSWHLIGC LGLAIFSGRF 150
    LIQWFYIESN NTKDFPLLFW KIGLLGGLLA LVYFIRIGDP INILCYGCGL 200
    FPSIANLRLF YKEQRSTPYL DTHCFLSAGE ASGDILGGKL IQSIKSLYPN 250
    IRFWGVGGPA MRQEGLQPIL NMEEFQVSGF AEVLGSLFRL YRNYRKILKT 300
    ILKHKPATLI FIDFPDFHLL LIKKLRKHGY RGKIIHYVCP SIWAWRPKRK 350
    RILEQHLDML LLILPFEEGL FKNTSLETVY LGHPLVEEIS DYKEQASWKE 400
    KFLNSDRPIV AAFPGSRRGD ISRNLRIQVQ AFLNSSLSQT HQFVVSSSSA 450
    KYDEIIEDTL KAEGCQHSQI IPMNFRYELM RSCDCALAKC GTIVLETALN 500
    QTPTIVMCRL RPFDTFLAKY IFKILLPAYS LPNIIMNSVI FPEFIGGKKD 550
    FHPEEIATAL DLLNQHGSKE KQKEDCRKLC KVMTTGQIAS EEFLKRIFDT 600
    LPAV 604
    Length:604
    Mass (Da):69,014
    Last modified:May 1, 1999 - v1
    Checksum:i094BF1B7013E07C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19101.1.
    AE002161 Genomic DNA. Translation: AAF38682.1.
    BA000008 Genomic DNA. Translation: BAA99173.1.
    AE009440 Genomic DNA. Translation: AAP98931.1.
    PIRiB72014.
    C86611.
    RefSeqiNP_225158.1. NC_000922.1.
    NP_301022.1. NC_002491.1.
    NP_445433.1. NC_002179.2.
    NP_877274.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19101; AAD19101; CPn_0965.
    AAF38682; AAF38682; CP_0895.
    AAP98931; AAP98931; CpB1002.
    BAA99173; BAA99173; BAA99173.
    GeneIDi1467681.
    895627.
    919726.
    963352.
    KEGGicpa:CP0895.
    cpj:CPj0965.
    cpn:CPn0965.
    cpt:CpB1002.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19101.1 .
    AE002161 Genomic DNA. Translation: AAF38682.1 .
    BA000008 Genomic DNA. Translation: BAA99173.1 .
    AE009440 Genomic DNA. Translation: AAP98931.1 .
    PIRi B72014.
    C86611.
    RefSeqi NP_225158.1. NC_000922.1.
    NP_301022.1. NC_002491.1.
    NP_445433.1. NC_002179.2.
    NP_877274.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z6U3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0965.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19101 ; AAD19101 ; CPn_0965 .
    AAF38682 ; AAF38682 ; CP_0895 .
    AAP98931 ; AAP98931 ; CpB1002 .
    BAA99173 ; BAA99173 ; BAA99173 .
    GeneIDi 1467681.
    895627.
    919726.
    963352.
    KEGGi cpa:CP0895.
    cpj:CPj0965.
    cpn:CPn0965.
    cpt:CpB1002.

    Phylogenomic databases

    eggNOGi COG3952.
    HOGENOMi HOG000034725.
    KOi K00748.
    OMAi KIIHYVC.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CPNE115711:GI7B-924-MONOMER.
    CPNE115713:GHEY-1007-MONOMER.
    CPNE138677:GH8N-999-MONOMER.
    CPNE182082:GH4N-1035-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view ]
    Pfami PF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view ]
    ProDomi PD339292. LAB_N. 2 hits.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiLPXB_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z6U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3