Q9Z6U3 (LPXB_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	CPn_0965, CP_0895, CpB1002

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	604 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	In the C-terminal section; belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 604	604	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000190160
Regions
	Region	1 – 220	220	Unknown HAMAP-Rule MF_00392
	Region	221 – 604	384	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

	Sequence		Length	Mass (Da)
	Q9Z6U3 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 094BF1B7013E07C8	FASTA	604	69,014
	10 20 30 40 50 60 MIPSGLVYLL YPLGFLASLF FGSAFSIQWW LSKKRKEVYA PRSFWILSSI GATLMIVHGT 70 80 90 100 110 120 IQSQFPVTVL HVINLIIYLR NLNITSSRPI SFRATLVLMA LSVVFVTLPF LYVNMEWMAS 130 140 150 160 170 180 PNIFHLPLPP AQLSWHLIGC LGLAIFSGRF LIQWFYIESN NTKDFPLLFW KIGLLGGLLA 190 200 210 220 230 240 LVYFIRIGDP INILCYGCGL FPSIANLRLF YKEQRSTPYL DTHCFLSAGE ASGDILGGKL 250 260 270 280 290 300 IQSIKSLYPN IRFWGVGGPA MRQEGLQPIL NMEEFQVSGF AEVLGSLFRL YRNYRKILKT 310 320 330 340 350 360 ILKHKPATLI FIDFPDFHLL LIKKLRKHGY RGKIIHYVCP SIWAWRPKRK RILEQHLDML 370 380 390 400 410 420 LLILPFEEGL FKNTSLETVY LGHPLVEEIS DYKEQASWKE KFLNSDRPIV AAFPGSRRGD 430 440 450 460 470 480 ISRNLRIQVQ AFLNSSLSQT HQFVVSSSSA KYDEIIEDTL KAEGCQHSQI IPMNFRYELM 490 500 510 520 530 540 RSCDCALAKC GTIVLETALN QTPTIVMCRL RPFDTFLAKY IFKILLPAYS LPNIIMNSVI 550 560 570 580 590 600 FPEFIGGKKD FHPEEIATAL DLLNQHGSKE KQKEDCRKLC KVMTTGQIAS EEFLKRIFDT LPAV

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD19101.1. AE002161 Genomic DNA. Translation: AAF38682.1. BA000008 Genomic DNA. Translation: BAA99173.1. AE009440 Genomic DNA. Translation: AAP98931.1.
PIR	B72014. C86611.
RefSeq	NP_225158.1. NC_000922.1. NP_301022.1. NC_002491.1. NP_445433.1. NC_002179.2. NP_877274.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z6U3.
ModBase	Search...
Protein-protein interaction databases
STRING	115713.CPn0965.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD19101; AAD19101; CPn_0965. AAF38682; AAF38682; CP_0895. AAP98931; AAP98931; CpB1002. BAA99173; BAA99173; BAA99173.
GeneID	1467681. 895627. 919726. 963352.
KEGG	cpa:CP0895. cpj:CPj0965. cpn:CPn0965. cpt:CpB1002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3952.
HOGENOM	HOG000034725.
KO	K00748.
OMA	CALAKCG.
ProtClustDB	PRK01021.
Enzyme and pathway databases
BioCyc	CPNE115711:GI7B-893-MONOMER. CPNE115713:GHEY-966-MONOMER. CPNE138677:GH8N-955-MONOMER. CPNE182082:GH4N-999-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB. Fused.
InterPro	IPR003835. Glyco_trans_19. IPR011499. Lipid_A_biosynth. [Graphical view]
Pfam	PF07578. LAB_N. 2 hits. PF02684. LpxB. 1 hit. [Graphical view]
ProDom	PD339292. LAB_N. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_CHLPN

Accession

Primary (citable) accession number: Q9Z6U3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program