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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei604 – 6041For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-921-MONOMER.
CPNE115713:GHEY-1010-MONOMER.
CPNE138677:GH8N-1002-MONOMER.
CPNE182082:GH4N-1038-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CPn_0968, CP_0892, CpB1005
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000583 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135319Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0968.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini285 – 426142SIS 1UniRule annotationAdd
BLAST
Domaini458 – 599142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z6U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIFGYLGN QDGVSIVLEG LAKLEYRGYD SAGLAAVVEQ ELFIRKTVGR
60 70 80 90 100
VQELSNLFQE REIPTASVIG HTRWATHGVP TEINAHPHVD EGRSCAVVHN
110 120 130 140 150
GIIENFKELR RELTAQGISF ASDTDSEIIV QLFSLYYQES QDLVFSFCQT
160 170 180 190 200
LAQLRGSVAC ALIHKDHPHT ILCASQESPL ILGLGKEETF IASDSRAFFK
210 220 230 240 250
YTRHSQALAS GEFAIVSQGK EPEVYNLELK KIHKDVRQIT CSEDASDKSG
260 270 280 290 300
YGYYMLKEIY DQPEVLEGLI QKHMDEEGHI LSEFLSDVPI KSFKEITIVA
310 320 330 340 350
CGSSYHAGYL AKYIIESLVS IPVHIEVASE FRYRRPYIGK DTLGILISQS
360 370 380 390 400
GETADTLAAL KELRRRNIAY LLGICNVPES AIALGVDHCL FLEAGVEIGV
410 420 430 440 450
ATTKAFTSQL LLLVFLGLKL ANVHGALTHA EQCSFGQGLQ SLPDLCQKLL
460 470 480 490 500
ANESLHSWAQ PYSYEDKFLF LGRRLMYPVV MEAALKLKEI AYIEANAYPG
510 520 530 540 550
GEMKHGPIAL ISKGTPVIAF CGDDIVYEKM IGNMMEVKAR HAHVIAIAPE
560 570 580 590 600
SREDIAAVSD QQIFVPDCHF LAAPVLYTIV GQVMAYAMAL AKGMEIDCPR

NLAKSVTVE
Length:609
Mass (Da):67,202
Last modified:January 23, 2007 - v4
Checksum:iDA213EADEFDC1344
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti321 – 3211I → T in AAD19104 (PubMed:10192388).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19104.1.
AE002161 Genomic DNA. Translation: AAF38679.1.
BA000008 Genomic DNA. Translation: BAA99176.1.
AE009440 Genomic DNA. Translation: AAP98934.1.
PIRiB81528.
E72012.
F86611.
RefSeqiNP_225161.1. NC_000922.1.

Genome annotation databases

EnsemblBacteriaiAAD19104; AAD19104; CPn_0968.
AAF38679; AAF38679; CP_0892.
AAP98934; AAP98934; CpB1005.
BAA99176; BAA99176; BAA99176.
GeneIDi895622.
KEGGicpa:CP0892.
cpj:CPj0968.
cpn:CPn0968.
cpt:CpB1005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19104.1.
AE002161 Genomic DNA. Translation: AAF38679.1.
BA000008 Genomic DNA. Translation: BAA99176.1.
AE009440 Genomic DNA. Translation: AAP98934.1.
PIRiB81528.
E72012.
F86611.
RefSeqiNP_225161.1. NC_000922.1.

3D structure databases

ProteinModelPortaliQ9Z6U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0968.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD19104; AAD19104; CPn_0968.
AAF38679; AAF38679; CP_0892.
AAP98934; AAP98934; CpB1005.
BAA99176; BAA99176; BAA99176.
GeneIDi895622.
KEGGicpa:CP0892.
cpj:CPj0968.
cpn:CPn0968.
cpt:CpB1005.

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-921-MONOMER.
CPNE115713:GHEY-1010-MONOMER.
CPNE138677:GH8N-1002-MONOMER.
CPNE182082:GH4N-1038-MONOMER.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiGLMS_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6U0
Secondary accession number(s): Q9JRV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.