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Q9Z6U0

- GLMS_CHLPN

UniProt

Q9Z6U0 - GLMS_CHLPN

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei604 – 6041For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-921-MONOMER.
    CPNE115713:GHEY-1010-MONOMER.
    CPNE138677:GH8N-1002-MONOMER.
    CPNE182082:GH4N-1038-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:CPn_0968, CP_0892, CpB1005
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135319Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn0968.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z6U0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini285 – 426142SIS 1UniRule annotationAdd
    BLAST
    Domaini458 – 599142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiGHKHTLA.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z6U0-1 [UniParc]FASTAAdd to Basket

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    MCGIFGYLGN QDGVSIVLEG LAKLEYRGYD SAGLAAVVEQ ELFIRKTVGR    50
    VQELSNLFQE REIPTASVIG HTRWATHGVP TEINAHPHVD EGRSCAVVHN 100
    GIIENFKELR RELTAQGISF ASDTDSEIIV QLFSLYYQES QDLVFSFCQT 150
    LAQLRGSVAC ALIHKDHPHT ILCASQESPL ILGLGKEETF IASDSRAFFK 200
    YTRHSQALAS GEFAIVSQGK EPEVYNLELK KIHKDVRQIT CSEDASDKSG 250
    YGYYMLKEIY DQPEVLEGLI QKHMDEEGHI LSEFLSDVPI KSFKEITIVA 300
    CGSSYHAGYL AKYIIESLVS IPVHIEVASE FRYRRPYIGK DTLGILISQS 350
    GETADTLAAL KELRRRNIAY LLGICNVPES AIALGVDHCL FLEAGVEIGV 400
    ATTKAFTSQL LLLVFLGLKL ANVHGALTHA EQCSFGQGLQ SLPDLCQKLL 450
    ANESLHSWAQ PYSYEDKFLF LGRRLMYPVV MEAALKLKEI AYIEANAYPG 500
    GEMKHGPIAL ISKGTPVIAF CGDDIVYEKM IGNMMEVKAR HAHVIAIAPE 550
    SREDIAAVSD QQIFVPDCHF LAAPVLYTIV GQVMAYAMAL AKGMEIDCPR 600
    NLAKSVTVE 609
    Length:609
    Mass (Da):67,202
    Last modified:January 23, 2007 - v4
    Checksum:iDA213EADEFDC1344
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti321 – 3211I → T in AAD19104. (PubMed:10192388)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19104.1.
    AE002161 Genomic DNA. Translation: AAF38679.1.
    BA000008 Genomic DNA. Translation: BAA99176.1.
    AE009440 Genomic DNA. Translation: AAP98934.1.
    PIRiB81528.
    E72012.
    F86611.
    RefSeqiNP_225161.1. NC_000922.1.
    NP_301025.1. NC_002491.1.
    NP_445430.1. NC_002179.2.
    NP_877277.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19104; AAD19104; CPn_0968.
    AAF38679; AAF38679; CP_0892.
    AAP98934; AAP98934; CpB1005.
    BAA99176; BAA99176; BAA99176.
    GeneIDi1467684.
    895622.
    919731.
    963348.
    KEGGicpa:CP0892.
    cpj:CPj0968.
    cpn:CPn0968.
    cpt:CpB1005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19104.1 .
    AE002161 Genomic DNA. Translation: AAF38679.1 .
    BA000008 Genomic DNA. Translation: BAA99176.1 .
    AE009440 Genomic DNA. Translation: AAP98934.1 .
    PIRi B81528.
    E72012.
    F86611.
    RefSeqi NP_225161.1. NC_000922.1.
    NP_301025.1. NC_002491.1.
    NP_445430.1. NC_002179.2.
    NP_877277.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z6U0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0968.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19104 ; AAD19104 ; CPn_0968 .
    AAF38679 ; AAF38679 ; CP_0892 .
    AAP98934 ; AAP98934 ; CpB1005 .
    BAA99176 ; BAA99176 ; BAA99176 .
    GeneIDi 1467684.
    895622.
    919731.
    963348.
    KEGGi cpa:CP0892.
    cpj:CPj0968.
    cpn:CPn0968.
    cpt:CpB1005.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi GHKHTLA.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-921-MONOMER.
    CPNE115713:GHEY-1010-MONOMER.
    CPNE138677:GH8N-1002-MONOMER.
    CPNE182082:GH4N-1038-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiGLMS_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z6U0
    Secondary accession number(s): Q9JRV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3