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Protein

Ribonucleoside-diphosphate reductase subunit alpha

Gene

nrdA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Enzyme regulationi

Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction (By similarity).By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei440SubstrateBy similarity1
Sitei456Important for hydrogen atom transferBy similarity1
Sitei463Allosteric effector bindingBy similarity1
Binding sitei484Substrate; via amide nitrogenBy similarity1
Sitei493Allosteric effector bindingBy similarity1
Active sitei668Proton acceptorBy similarity1
Active sitei670Cysteine radical intermediateBy similarity1
Active sitei672Proton acceptorBy similarity1
Sitei685Important for hydrogen atom transferBy similarity1
Sitei988Important for electron transferBy similarity1
Sitei989Important for electron transferBy similarity1
Sitei1040Interacts with thioredoxin/glutaredoxinBy similarity1
Sitei1043Interacts with thioredoxin/glutaredoxinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit alpha (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase
Gene namesi
Name:nrdA
Ordered Locus Names:CPn_0984, CP_0872, CpB1021
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872111 – 1044Ribonucleoside-diphosphate reductase subunit alphaAdd BLAST1044

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi456 ↔ 685Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9Z6S5

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi182082.CpB1021

Structurei

3D structure databases

ProteinModelPortaliQ9Z6S5
SMRiQ9Z6S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 111ATP-cone 1PROSITE-ProRule annotationAdd BLAST103
Domaini118 – 217ATP-cone 2PROSITE-ProRule annotationAdd BLAST100
Domaini235 – 325ATP-cone 3PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni455 – 456Substrate bindingBy similarity2
Regioni668 – 672Substrate bindingBy similarity5
Regioni855 – 859Substrate bindingBy similarity5

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105BZH Bacteria
COG0209 LUCA
HOGENOMiHOG000057036
KOiK00525
OMAiFVPFNQD
OrthoDBiPOG091H03NG

Family and domain databases

InterProiView protein in InterPro
IPR005144 ATP-cone_dom
IPR013346 NrdE_NrdA
IPR000788 RNR_lg_C
IPR013509 RNR_lsu_N
IPR008926 RNR_R1-su_N
PfamiView protein in Pfam
PF03477 ATP-cone, 2 hits
PF02867 Ribonuc_red_lgC, 1 hit
PF00317 Ribonuc_red_lgN, 1 hit
PRINTSiPR01183 RIBORDTASEM1
SUPFAMiSSF48168 SSF48168, 1 hit
TIGRFAMsiTIGR02506 NrdE_NrdA, 1 hit
PROSITEiView protein in PROSITE
PS51161 ATP_CONE, 3 hits
PS00089 RIBORED_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z6S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEVEEKHYT IVKRNGMFVP FNQDRIFQAL EAAFRDTRSL ETSSPLPKDL
60 70 80 90 100
EESIAQITHK VVKEVLAKIS EGQVVTVERI QDLVESQLYI SGLQDVARDY
110 120 130 140 150
IVYRDQRKAE RGNSSSIIAI IRRDGGSAKF NPMKISAALE KAFRATLQIN
160 170 180 190 200
GMTPPATLSE INDLTLRIVE DVLSLHGEEA INLEEIQDIV EKQLMVAGYY
210 220 230 240 250
DVAKNYILYR EARARARANK DQDGQEEFVP QEETYVVQKE DGTTYLLRKT
260 270 280 290 300
DLEKRFSWAC KRFPKTTDSQ LLADMAFMNL YSGIKEDEVT TACIMAARAN
310 320 330 340 350
IEREPDYAFI AAELLTSSLY EETLGCSSQD PNLSEIHKKH FKEYILNGEE
360 370 380 390 400
YRLNPQLKDY DLDALSEVLD LSRDQQFSYM GVQNLYDRYF NLHEGRRLET
410 420 430 440 450
AQIFWMRVSM GLALNEGEQK NFWAITFYNL LSTFRYTPAT PTLFNSGMRH
460 470 480 490 500
SQLSSCYLST VKDDLSHIYK VISDNALLSK WAGGIGNDWT DVRATGAVIK
510 520 530 540 550
GTNGKSQGVI PFIKVANDTA IAVNQGGKRK GAMCVYLENW HLDYEDFLEL
560 570 580 590 600
RKNTGDERRR THDINTASWI PDLFFKRLEK KGMWTLFSPD DVPGLHEAYG
610 620 630 640 650
LEFEKLYEEY ERKVESGEIR LYKKVEAEVL WRKMLSMLYE TGHPWITFKD
660 670 680 690 700
PSNIRSNQDH VGVVRCSNLC TEILLNCSES ETAVCNLGSI NLVEHIRNDK
710 720 730 740 750
LDEEKLKETI SIAIRILDNV IDLNFYPTPE AKQANLTHRA VGLGVMGFQD
760 770 780 790 800
VLYELNISYA SQEAVEFSDE CSEIIAYYAI LASSLLAKER GTYASYSGSK
810 820 830 840 850
WDRGYLPLDT IELLKETRGE HNVLVDTSSK KDWTPVRDTI QKYGMRNSQV
860 870 880 890 900
MAIAPTATIS NIIGVTQSIE PMYKHLFVKS NLSGEFTIPN TYLIKKLKEL
910 920 930 940 950
GLWDAEMLDD LKYFDGSLLE IERIPNHLKK LFLTAFEIEP EWIIECTSRR
960 970 980 990 1000
QKWIDMGVSL NLYLAEPDGK KLSNMYLTAW KKGLKTTYYL RSQAATSVEK
1010 1020 1030 1040
SFIDINKRGI QPRWMKNKSA STSIVVERKT TPVCSMEEGC ESCQ
Length:1,044
Mass (Da):119,399
Last modified:May 1, 1999 - v1
Checksum:i0A7379FA01B7372E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19121.1
AE002161 Genomic DNA Translation: AAF38661.1
BA000008 Genomic DNA Translation: BAA99191.1
AE009440 Genomic DNA Translation: AAP98950.1
PIRiA72010
E86613
RefSeqiNP_225178.1, NC_000922.1
WP_010883617.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19121; AAD19121; CPn_0984
AAF38661; AAF38661; CP_0872
AAP98950; AAP98950; CpB1021
BAA99191; BAA99191; BAA99191
GeneIDi895606
KEGGicpa:CP_0872
cpj:nrdA
cpn:CPn0984
cpt:CpB1021
PATRICifig|115713.3.peg.1079

Similar proteinsi

Entry informationi

Entry nameiRIR1_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6S5
Secondary accession number(s): Q9JQC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health