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Q9Z6S4 (RIR2_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:CPn_0985, CP_0871, CpB1022
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence caution

The sequence AAP98951.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190474

Sites

Active site1291 By similarity
Metal binding891Iron 1 By similarity
Metal binding1201Iron 1 By similarity
Metal binding1201Iron 2 By similarity
Metal binding1231Iron 1 By similarity
Metal binding1931Iron 2 By similarity
Metal binding2271Iron 2 By similarity
Metal binding2301Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z6S4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 498D8E4625197D1C

FASTA34640,200
        10         20         30         40         50         60 
MEADILDGKL KRVEVSKKGL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN WLPTEVPMAR 

        70         80         90        100        110        120 
DIELWKSDEL SEDERRVILL NLGFFSTAES LVGNNIVLAI FKHITNPEAR QYLLRQAFEE 

       130        140        150        160        170        180 
AVHTHTFLYI CESLGLDEGE VFNAYNERAS IRAKDDFQMT LTVDVLDPNF SVQSSEGLGQ 

       190        200        210        220        230        240 
FIKNLVGYYI IMEGIFFYSG FVMILSFHRQ NKMTGIGEQY QYILRDETIH LNFGIDLING 

       250        260        270        280        290        300 
IKEENPEVWT TELQEEIVAL IEKAVELEIE YAKDCLPRGI LGLRSSMFID YVRHIADRRL 

       310        320        330        340 
ERIGLKPIYH SRNPFPWMSE TMDLNKEKNF FETRVTEYQT AGNLSW 

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001363 Genomic DNA. Translation: AAD19122.1.
AE002161 Genomic DNA. Translation: AAF38660.1.
BA000008 Genomic DNA. Translation: BAA99192.1.
AE009440 Genomic DNA. Translation: AAP98951.1. Different initiation.
PIRB72010.
F86613.
RefSeqNP_225179.1. NC_000922.1.
NP_301040.1. NC_002491.1.
NP_445409.1. NC_002179.2.
NP_877294.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z6S4.
SMRQ9Z6S4. Positions 2-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING115713.CPn0985.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD19122; AAD19122; CPn_0985.
AAF38660; AAF38660; CP_0871.
AAP98951; AAP98951; CpB1022.
BAA99192; BAA99192; BAA99192.
GeneID1467701.
895607.
919749.
963323.
KEGGcpa:CP0871.
cpj:CPj0985.
cpn:CPn0985.
cpt:CpB1022.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
HOGENOMHOG000255976.
KOK00526.
OMAACANHWM.
OrthoDBEOG6J48J7.
ProtClustDBPRK07209.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-900-MONOMER.
CPNE115713:GHEY-1027-MONOMER.
CPNE138677:GH8N-1017-MONOMER.
CPNE182082:GH4N-1055-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFPIRSF000355. NrdB. 1 hit.
SUPFAMSSF47240. SSF47240. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIR2_CHLPN
AccessionPrimary (citable) accession number: Q9Z6S4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways