Q9Z6S4 (RIR2_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonucleoside-diphosphate reductase subunit beta
EC=1.17.4.1

Alternative name(s):
Ribonucleotide reductase small subunit

Gene names

Name:	nrdB
Ordered Locus Names:	CPn_0985, CP_0871, CpB1022

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.
Catalytic activity	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Genetic information processing; DNA replication.
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase small chain family.
Sequence caution	The sequence AAP98951.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	DNA replication
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-UniPathway deoxyribonucleoside diphosphate metabolic process Inferred from electronic annotation. Source: InterPro deoxyribonucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Ribonucleoside-diphosphate reductase subunit beta		PRO_0000190474
Sites
	Active site	129	1	By similarity
	Metal binding	89	1	Iron 1 By similarity
	Metal binding	120	1	Iron 1 By similarity
	Metal binding	120	1	Iron 2 By similarity
	Metal binding	123	1	Iron 1 By similarity
	Metal binding	193	1	Iron 2 By similarity
	Metal binding	227	1	Iron 2 By similarity
	Metal binding	230	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z6S4 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 498D8E4625197D1C	FASTA	346	40,200
	10 20 30 40 50 60 MEADILDGKL KRVEVSKKGL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN WLPTEVPMAR 70 80 90 100 110 120 DIELWKSDEL SEDERRVILL NLGFFSTAES LVGNNIVLAI FKHITNPEAR QYLLRQAFEE 130 140 150 160 170 180 AVHTHTFLYI CESLGLDEGE VFNAYNERAS IRAKDDFQMT LTVDVLDPNF SVQSSEGLGQ 190 200 210 220 230 240 FIKNLVGYYI IMEGIFFYSG FVMILSFHRQ NKMTGIGEQY QYILRDETIH LNFGIDLING 250 260 270 280 290 300 IKEENPEVWT TELQEEIVAL IEKAVELEIE YAKDCLPRGI LGLRSSMFID YVRHIADRRL 310 320 330 340 ERIGLKPIYH SRNPFPWMSE TMDLNKEKNF FETRVTEYQT AGNLSW

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD19122.1. AE002161 Genomic DNA. Translation: AAF38660.1. BA000008 Genomic DNA. Translation: BAA99192.1. AE009440 Genomic DNA. Translation: AAP98951.1. Different initiation.
PIR	B72010. F86613.
RefSeq	NP_225179.1. NC_000922.1. NP_301040.1. NC_002491.1. NP_445409.1. NC_002179.2. NP_877294.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z6S4.
SMR	Q9Z6S4. Positions 2-318.
ModBase	Search...
Protein-protein interaction databases
STRING	115713.CPn0985.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD19122; AAD19122; CPn_0985. AAF38660; AAF38660; CP_0871. AAP98951; AAP98951; CpB1022. BAA99192; BAA99192; BAA99192.
GeneID	1467701. 895607. 919749. 963323.
KEGG	cpa:CP0871. cpj:CPj0985. cpn:CPn0985. cpt:CpB1022.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0208.
HOGENOM	HOG000255976.
KO	K00526.
OMA	ICNRRCQ.
ProtClustDB	PRK07209.
Enzyme and pathway databases
BioCyc	CPNE115711:GI7B-900-MONOMER. CPNE115713:GHEY-1027-MONOMER. CPNE138677:GH8N-1017-MONOMER. CPNE182082:GH4N-1055-MONOMER.
UniPathway	UPA00326.
Family and domain databases
Gene3D	1.10.620.20. 1 hit.
InterPro	IPR009078. Ferritin-like_SF. IPR012348. RNR-rel. IPR026023. RNR_bsu_prok. IPR000358. RNR_small. [Graphical view]
PANTHER	PTHR23409. PTHR23409. 1 hit.
Pfam	PF00268. Ribonuc_red_sm. 1 hit. [Graphical view]
PIRSF	PIRSF000355. NrdB. 1 hit.
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00368. RIBORED_SMALL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIR2_CHLPN

Accession

Primary (citable) accession number: Q9Z6S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program