Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z6S4

- RIR2_CHLPN

UniProt

Q9Z6S4 - RIR2_CHLPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1By similarity
Metal bindingi120 – 1201Iron 1By similarity
Metal bindingi120 – 1201Iron 2By similarity
Metal bindingi123 – 1231Iron 1By similarity
Active sitei129 – 1291By similarity
Metal bindingi193 – 1931Iron 2By similarity
Metal bindingi227 – 2271Iron 2By similarity
Metal bindingi230 – 2301Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-900-MONOMER.
CPNE115713:GHEY-1027-MONOMER.
CPNE138677:GH8N-1017-MONOMER.
CPNE182082:GH4N-1055-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:CPn_0985, CP_0871, CpB1022
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190474Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi115713.CPn0985.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6S4.
SMRiQ9Z6S4. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000255976.
KOiK00526.
OMAiEAIECEV.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6S4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEADILDGKL KRVEVSKKGL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN
60 70 80 90 100
WLPTEVPMAR DIELWKSDEL SEDERRVILL NLGFFSTAES LVGNNIVLAI
110 120 130 140 150
FKHITNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEGE VFNAYNERAS
160 170 180 190 200
IRAKDDFQMT LTVDVLDPNF SVQSSEGLGQ FIKNLVGYYI IMEGIFFYSG
210 220 230 240 250
FVMILSFHRQ NKMTGIGEQY QYILRDETIH LNFGIDLING IKEENPEVWT
260 270 280 290 300
TELQEEIVAL IEKAVELEIE YAKDCLPRGI LGLRSSMFID YVRHIADRRL
310 320 330 340
ERIGLKPIYH SRNPFPWMSE TMDLNKEKNF FETRVTEYQT AGNLSW
Length:346
Mass (Da):40,200
Last modified:May 1, 1999 - v1
Checksum:i498D8E4625197D1C
GO

Sequence cautioni

The sequence AAP98951.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19122.1.
AE002161 Genomic DNA. Translation: AAF38660.1.
BA000008 Genomic DNA. Translation: BAA99192.1.
AE009440 Genomic DNA. Translation: AAP98951.1. Different initiation.
PIRiB72010.
F86613.
RefSeqiNP_225179.1. NC_000922.1.
NP_301040.1. NC_002491.1.
NP_445409.1. NC_002179.2.
NP_877294.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19122; AAD19122; CPn_0985.
AAF38660; AAF38660; CP_0871.
AAP98951; AAP98951; CpB1022.
BAA99192; BAA99192; BAA99192.
GeneIDi1467701.
895607.
919749.
963323.
KEGGicpa:CP0871.
cpj:CPj0985.
cpn:CPn0985.
cpt:CpB1022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19122.1 .
AE002161 Genomic DNA. Translation: AAF38660.1 .
BA000008 Genomic DNA. Translation: BAA99192.1 .
AE009440 Genomic DNA. Translation: AAP98951.1 . Different initiation.
PIRi B72010.
F86613.
RefSeqi NP_225179.1. NC_000922.1.
NP_301040.1. NC_002491.1.
NP_445409.1. NC_002179.2.
NP_877294.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6S4.
SMRi Q9Z6S4. Positions 2-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0985.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19122 ; AAD19122 ; CPn_0985 .
AAF38660 ; AAF38660 ; CP_0871 .
AAP98951 ; AAP98951 ; CpB1022 .
BAA99192 ; BAA99192 ; BAA99192 .
GeneIDi 1467701.
895607.
919749.
963323.
KEGGi cpa:CP0871.
cpj:CPj0985.
cpn:CPn0985.
cpt:CpB1022.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000255976.
KOi K00526.
OMAi EAIECEV.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci CPNE115711:GI7B-900-MONOMER.
CPNE115713:GHEY-1027-MONOMER.
CPNE138677:GH8N-1017-MONOMER.
CPNE182082:GH4N-1055-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiRIR2_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3