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Q9Z6S4

- RIR2_CHLPN

UniProt

Q9Z6S4 - RIR2_CHLPN

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Protein
Ribonucleoside-diphosphate reductase subunit beta
Gene
nrdB, CPn_0985, CP_0871, CpB1022
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1 By similarity
Metal bindingi120 – 1201Iron 1 By similarity
Metal bindingi120 – 1201Iron 2 By similarity
Metal bindingi123 – 1231Iron 1 By similarity
Active sitei129 – 1291 By similarity
Metal bindingi193 – 1931Iron 2 By similarity
Metal bindingi227 – 2271Iron 2 By similarity
Metal bindingi230 – 2301Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  3. deoxyribonucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-900-MONOMER.
CPNE115713:GHEY-1027-MONOMER.
CPNE138677:GH8N-1017-MONOMER.
CPNE182082:GH4N-1055-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:CPn_0985, CP_0871, CpB1022
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190474Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi115713.CPn0985.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6S4.
SMRiQ9Z6S4. Positions 2-318.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000255976.
KOiK00526.
OMAiEAIECEV.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6S4-1 [UniParc]FASTAAdd to Basket

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MEADILDGKL KRVEVSKKGL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN    50
WLPTEVPMAR DIELWKSDEL SEDERRVILL NLGFFSTAES LVGNNIVLAI 100
FKHITNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEGE VFNAYNERAS 150
IRAKDDFQMT LTVDVLDPNF SVQSSEGLGQ FIKNLVGYYI IMEGIFFYSG 200
FVMILSFHRQ NKMTGIGEQY QYILRDETIH LNFGIDLING IKEENPEVWT 250
TELQEEIVAL IEKAVELEIE YAKDCLPRGI LGLRSSMFID YVRHIADRRL 300
ERIGLKPIYH SRNPFPWMSE TMDLNKEKNF FETRVTEYQT AGNLSW 346
Length:346
Mass (Da):40,200
Last modified:May 1, 1999 - v1
Checksum:i498D8E4625197D1C
GO

Sequence cautioni

The sequence AAP98951.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19122.1.
AE002161 Genomic DNA. Translation: AAF38660.1.
BA000008 Genomic DNA. Translation: BAA99192.1.
AE009440 Genomic DNA. Translation: AAP98951.1. Different initiation.
PIRiB72010.
F86613.
RefSeqiNP_225179.1. NC_000922.1.
NP_301040.1. NC_002491.1.
NP_445409.1. NC_002179.2.
NP_877294.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19122; AAD19122; CPn_0985.
AAF38660; AAF38660; CP_0871.
AAP98951; AAP98951; CpB1022.
BAA99192; BAA99192; BAA99192.
GeneIDi1467701.
895607.
919749.
963323.
KEGGicpa:CP0871.
cpj:CPj0985.
cpn:CPn0985.
cpt:CpB1022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19122.1 .
AE002161 Genomic DNA. Translation: AAF38660.1 .
BA000008 Genomic DNA. Translation: BAA99192.1 .
AE009440 Genomic DNA. Translation: AAP98951.1 . Different initiation.
PIRi B72010.
F86613.
RefSeqi NP_225179.1. NC_000922.1.
NP_301040.1. NC_002491.1.
NP_445409.1. NC_002179.2.
NP_877294.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6S4.
SMRi Q9Z6S4. Positions 2-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0985.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19122 ; AAD19122 ; CPn_0985 .
AAF38660 ; AAF38660 ; CP_0871 .
AAP98951 ; AAP98951 ; CpB1022 .
BAA99192 ; BAA99192 ; BAA99192 .
GeneIDi 1467701.
895607.
919749.
963323.
KEGGi cpa:CP0871.
cpj:CPj0985.
cpn:CPn0985.
cpt:CpB1022.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000255976.
KOi K00526.
OMAi EAIECEV.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci CPNE115711:GI7B-900-MONOMER.
CPNE115713:GHEY-1027-MONOMER.
CPNE138677:GH8N-1017-MONOMER.
CPNE182082:GH4N-1055-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiRIR2_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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