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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54S-adenosyl-L-methionineUniRule annotation1
Binding sitei79S-adenosyl-L-methionineUniRule annotation1
Active sitei129By similarity1
Binding sitei129S-adenosyl-L-methionineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:CPn_0986, CP_0869, CPj0986, CpB1023
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713161 – 224tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST224

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB1023

Structurei

3D structure databases

ProteinModelPortaliQ9Z6S3
SMRiQ9Z6S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SGN Bacteria
COG0220 LUCA
HOGENOMiHOG000034940
KOiK03439
OMAiGHALEYC
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z6S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQDLSPPF LWKERRPCIQ DGVLYVPRHY FEHQNFSTSY HQEFFQNHTS
60 70 80 90 100
IACELCSGNG DWVVAQAQKD PQVLWIAVEQ RFDRVRKIWS KMINHQIQNL
110 120 130 140 150
RIVCGTAETF FQYYVPDQFL QRLVVNFPDP WPKMRHRKHR LLQPSFVQEI
160 170 180 190 200
SRSLQDSAVF ALATDDKTYL LESIEALQTH LAPRMETPYY IKMTDTYGNS
210 220
WFENLWRTKG QEIFYTEFIK KAGI
Length:224
Mass (Da):26,729
Last modified:May 1, 1999 - v1
Checksum:i60C969E22FB7F028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19123.1
AE002161 Genomic DNA Translation: AAF38658.1
BA000008 Genomic DNA Translation: BAA99193.1
AE009440 Genomic DNA Translation: AAP98952.1
PIRiC72010
G86613
RefSeqiNP_225180.1, NC_000922.1
WP_010883619.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19123; AAD19123; CPn_0986
AAF38658; AAF38658; CP_0869
AAP98952; AAP98952; CpB1023
BAA99193; BAA99193; BAA99193
GeneIDi895603
KEGGicpa:CP_0869
cpj:yggH
cpn:CPn0986
cpt:CpB1023
PATRICifig|115713.3.peg.1081

Similar proteinsi

Entry informationi

Entry nameiTRMB_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health