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Q9Z6S3

- TRMB_CHLPN

UniProt

Q9Z6S3 - TRMB_CHLPN

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541S-adenosyl-L-methionineUniRule annotation
    Binding sitei79 – 791S-adenosyl-L-methionineUniRule annotation
    Active sitei129 – 1291By similarity
    Binding sitei129 – 1291S-adenosyl-L-methionineUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-898-MONOMER.
    CPNE115713:GHEY-1028-MONOMER.
    CPNE138677:GH8N-1018-MONOMER.
    CPNE182082:GH4N-1056-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:CPn_0986, CP_0869, CPj0986, CpB1023
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_0000171316Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0986.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z6S3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000034940.
    KOiK03439.
    OMAiIVELAMN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z6S3-1 [UniParc]FASTAAdd to Basket

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    MKPQDLSPPF LWKERRPCIQ DGVLYVPRHY FEHQNFSTSY HQEFFQNHTS    50
    IACELCSGNG DWVVAQAQKD PQVLWIAVEQ RFDRVRKIWS KMINHQIQNL 100
    RIVCGTAETF FQYYVPDQFL QRLVVNFPDP WPKMRHRKHR LLQPSFVQEI 150
    SRSLQDSAVF ALATDDKTYL LESIEALQTH LAPRMETPYY IKMTDTYGNS 200
    WFENLWRTKG QEIFYTEFIK KAGI 224
    Length:224
    Mass (Da):26,729
    Last modified:May 1, 1999 - v1
    Checksum:i60C969E22FB7F028
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19123.1.
    AE002161 Genomic DNA. Translation: AAF38658.1.
    BA000008 Genomic DNA. Translation: BAA99193.1.
    AE009440 Genomic DNA. Translation: AAP98952.1.
    PIRiC72010.
    G86613.
    RefSeqiNP_225180.1. NC_000922.1.
    NP_301041.1. NC_002491.1.
    NP_445407.1. NC_002179.2.
    NP_877295.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19123; AAD19123; CPn_0986.
    AAF38658; AAF38658; CP_0869.
    AAP98952; AAP98952; CpB1023.
    BAA99193; BAA99193; BAA99193.
    GeneIDi1467702.
    895603.
    919748.
    963320.
    KEGGicpa:CP0869.
    cpj:CPj0986.
    cpn:CPn0986.
    cpt:CpB1023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19123.1 .
    AE002161 Genomic DNA. Translation: AAF38658.1 .
    BA000008 Genomic DNA. Translation: BAA99193.1 .
    AE009440 Genomic DNA. Translation: AAP98952.1 .
    PIRi C72010.
    G86613.
    RefSeqi NP_225180.1. NC_000922.1.
    NP_301041.1. NC_002491.1.
    NP_445407.1. NC_002179.2.
    NP_877295.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z6S3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19123 ; AAD19123 ; CPn_0986 .
    AAF38658 ; AAF38658 ; CP_0869 .
    AAP98952 ; AAP98952 ; CpB1023 .
    BAA99193 ; BAA99193 ; BAA99193 .
    GeneIDi 1467702.
    895603.
    919748.
    963320.
    KEGGi cpa:CP0869.
    cpj:CPj0986.
    cpn:CPn0986.
    cpt:CpB1023.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000034940.
    KOi K03439.
    OMAi IVELAMN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CPNE115711:GI7B-898-MONOMER.
    CPNE115713:GHEY-1028-MONOMER.
    CPNE138677:GH8N-1018-MONOMER.
    CPNE182082:GH4N-1056-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiTRMB_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z6S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3