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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541S-adenosyl-L-methionineUniRule annotation
Binding sitei79 – 791S-adenosyl-L-methionineUniRule annotation
Active sitei129 – 1291By similarity
Binding sitei129 – 1291S-adenosyl-L-methionineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-898-MONOMER.
CPNE115713:GHEY-1028-MONOMER.
CPNE138677:GH8N-1018-MONOMER.
CPNE182082:GH4N-1056-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:CPn_0986, CP_0869, CPj0986, CpB1023
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_0000171316Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0986.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000034940.
KOiK03439.
OMAiCYKTCRR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z6S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQDLSPPF LWKERRPCIQ DGVLYVPRHY FEHQNFSTSY HQEFFQNHTS
60 70 80 90 100
IACELCSGNG DWVVAQAQKD PQVLWIAVEQ RFDRVRKIWS KMINHQIQNL
110 120 130 140 150
RIVCGTAETF FQYYVPDQFL QRLVVNFPDP WPKMRHRKHR LLQPSFVQEI
160 170 180 190 200
SRSLQDSAVF ALATDDKTYL LESIEALQTH LAPRMETPYY IKMTDTYGNS
210 220
WFENLWRTKG QEIFYTEFIK KAGI
Length:224
Mass (Da):26,729
Last modified:May 1, 1999 - v1
Checksum:i60C969E22FB7F028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19123.1.
AE002161 Genomic DNA. Translation: AAF38658.1.
BA000008 Genomic DNA. Translation: BAA99193.1.
AE009440 Genomic DNA. Translation: AAP98952.1.
PIRiC72010.
G86613.
RefSeqiNP_225180.1. NC_000922.1.
NP_301041.1. NC_002491.1.
NP_445407.1. NC_002179.2.
NP_877295.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19123; AAD19123; CPn_0986.
AAF38658; AAF38658; CP_0869.
AAP98952; AAP98952; CpB1023.
BAA99193; BAA99193; BAA99193.
GeneIDi1467702.
895603.
919748.
963320.
KEGGicpa:CP0869.
cpj:CPj0986.
cpn:CPn0986.
cpt:CpB1023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19123.1.
AE002161 Genomic DNA. Translation: AAF38658.1.
BA000008 Genomic DNA. Translation: BAA99193.1.
AE009440 Genomic DNA. Translation: AAP98952.1.
PIRiC72010.
G86613.
RefSeqiNP_225180.1. NC_000922.1.
NP_301041.1. NC_002491.1.
NP_445407.1. NC_002179.2.
NP_877295.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9Z6S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD19123; AAD19123; CPn_0986.
AAF38658; AAF38658; CP_0869.
AAP98952; AAP98952; CpB1023.
BAA99193; BAA99193; BAA99193.
GeneIDi1467702.
895603.
919748.
963320.
KEGGicpa:CP0869.
cpj:CPj0986.
cpn:CPn0986.
cpt:CpB1023.

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000034940.
KOiK03439.
OMAiCYKTCRR.
OrthoDBiEOG6K6VBC.

Enzyme and pathway databases

UniPathwayiUPA00989.
BioCyciCPNE115711:GI7B-898-MONOMER.
CPNE115713:GHEY-1028-MONOMER.
CPNE138677:GH8N-1018-MONOMER.
CPNE182082:GH4N-1056-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiTRMB_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.