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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi486MagnesiumUniRule annotation1
Metal bindingi492MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CPn_0999, CP_0855, CpB1037
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295791 – 694Polyribonucleotide nucleotidyltransferaseAdd BLAST694

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB1037

Structurei

3D structure databases

ProteinModelPortaliQ9Z6R0
SMRiQ9Z6R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini553 – 612KHUniRule annotationAdd BLAST60
Domaini622 – 690S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z6R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFQTISINL TEGKILVFET GKIARQANGA VLVRSGETCV FASACAVDLD
60 70 80 90 100
DKVDFLPLRV DYQEKFSSTG KTLGGFIKRE GRPSEKEILV SRLIDRSLRP
110 120 130 140 150
SFPYRLMQDV QVLSYVWSYD GQVLPDPLAI CAASAALAIS DIPQSNIVAG
160 170 180 190 200
VRIGCIDNQW VINPTKTELA SSTLDLVLAG TENAILMIEG HCDFFTEEQV
210 220 230 240 250
LDAIEFGHKH IVTICKRLQL WQEEVGKSKN LSAVYPLPAE VLTAVKECAQ
260 270 280 290 300
DKFTELFNIK DKKVHAATAH EIEENILEKL QREDDDLFSS FNIKAACKTL
310 320 330 340 350
KSDTMRALIR DREIRADGRS LTTVRPITIE TSYLPRTHGS CLFTRGETQT
360 370 380 390 400
LAVCTLGSEA MAQRYEDLNG EGLSKFYLQY FFPPFSVGEV GRIGSPGRRE
410 420 430 440 450
IGHGKLAEKA LSHALPDSAT FPYTIRIESN ITESNGSSSM ASVCGGCLAL
460 470 480 490 500
MDAGVPISSP IAGIAMGLIL DDQGAIILSD ISGLEDHLGD MDFKIAGSGK
510 520 530 540 550
GITAFQMDIK VEGITPAIMK KALSQAKQGC NDILNIMNEA LSAPKADLSQ
560 570 580 590 600
YAPRIETMQI KPTKIASVIG PGGKQIRQII EETGVQIDVN DLGVVSISAS
610 620 630 640 650
SASAINKAKE IIEGLVGEVE VGKTYRGRVT SVVAFGAFVE VLPGKEGLCH
660 670 680 690
ISECSRQRIE NISDVVKEGD IIDVKLLSIN EKGQLKLSHK ATLE
Length:694
Mass (Da):75,347
Last modified:May 1, 1999 - v1
Checksum:i5D1D9C1E0DF9D62E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225V → I in AAP98966 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19136.1
AE002161 Genomic DNA Translation: AAF38644.1
BA000008 Genomic DNA Translation: BAA99206.1
AE009440 Genomic DNA Translation: AAP98966.1
PIRiD86615
G72009
RefSeqiNP_225193.1, NC_000922.1
WP_010883632.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19136; AAD19136; CPn_0999
AAF38644; AAF38644; CP_0855
AAP98966; AAP98966; CpB1037
BAA99206; BAA99206; BAA99206
GeneIDi894682
KEGGicpa:CP_0855
cpj:pnp
cpn:CPn0999
cpt:CpB1037
PATRICifig|115713.3.peg.1094

Similar proteinsi

Entry informationi

Entry nameiPNP_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6R0
Secondary accession number(s): Q7AHZ1, Q7DE66, Q7VPR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health