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Q9Z6R0

- PNP_CHLPN

UniProt

Q9Z6R0 - PNP_CHLPN

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi486 – 4861MagnesiumUniRule annotation
    Metal bindingi492 – 4921MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-882-MONOMER.
    CPNE115713:GHEY-1043-MONOMER.
    CPNE138677:GH8N-1033-MONOMER.
    CPNE182082:GH4N-1072-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:CPn_0999, CP_0855, CpB1037
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694Polyribonucleotide nucleotidyltransferasePRO_0000329579Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0999.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z6R0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini553 – 61260KHUniRule annotationAdd
    BLAST
    Domaini622 – 69069S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiRRIITHD.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z6R0-1 [UniParc]FASTAAdd to Basket

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    MNFQTISINL TEGKILVFET GKIARQANGA VLVRSGETCV FASACAVDLD    50
    DKVDFLPLRV DYQEKFSSTG KTLGGFIKRE GRPSEKEILV SRLIDRSLRP 100
    SFPYRLMQDV QVLSYVWSYD GQVLPDPLAI CAASAALAIS DIPQSNIVAG 150
    VRIGCIDNQW VINPTKTELA SSTLDLVLAG TENAILMIEG HCDFFTEEQV 200
    LDAIEFGHKH IVTICKRLQL WQEEVGKSKN LSAVYPLPAE VLTAVKECAQ 250
    DKFTELFNIK DKKVHAATAH EIEENILEKL QREDDDLFSS FNIKAACKTL 300
    KSDTMRALIR DREIRADGRS LTTVRPITIE TSYLPRTHGS CLFTRGETQT 350
    LAVCTLGSEA MAQRYEDLNG EGLSKFYLQY FFPPFSVGEV GRIGSPGRRE 400
    IGHGKLAEKA LSHALPDSAT FPYTIRIESN ITESNGSSSM ASVCGGCLAL 450
    MDAGVPISSP IAGIAMGLIL DDQGAIILSD ISGLEDHLGD MDFKIAGSGK 500
    GITAFQMDIK VEGITPAIMK KALSQAKQGC NDILNIMNEA LSAPKADLSQ 550
    YAPRIETMQI KPTKIASVIG PGGKQIRQII EETGVQIDVN DLGVVSISAS 600
    SASAINKAKE IIEGLVGEVE VGKTYRGRVT SVVAFGAFVE VLPGKEGLCH 650
    ISECSRQRIE NISDVVKEGD IIDVKLLSIN EKGQLKLSHK ATLE 694
    Length:694
    Mass (Da):75,347
    Last modified:May 1, 1999 - v1
    Checksum:i5D1D9C1E0DF9D62E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti225 – 2251V → I in AAP98966. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19136.1.
    AE002161 Genomic DNA. Translation: AAF38644.1.
    BA000008 Genomic DNA. Translation: BAA99206.1.
    AE009440 Genomic DNA. Translation: AAP98966.1.
    PIRiD86615.
    G72009.
    RefSeqiNP_225193.1. NC_000922.1.
    NP_301054.1. NC_002491.1.
    NP_445393.1. NC_002179.2.
    NP_877309.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19136; AAD19136; CPn_0999.
    AAF38644; AAF38644; CP_0855.
    AAP98966; AAP98966; CpB1037.
    BAA99206; BAA99206; BAA99206.
    GeneIDi1467716.
    894682.
    919768.
    963295.
    KEGGicpa:CP0855.
    cpj:CPj0999.
    cpn:CPn0999.
    cpt:CpB1037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19136.1 .
    AE002161 Genomic DNA. Translation: AAF38644.1 .
    BA000008 Genomic DNA. Translation: BAA99206.1 .
    AE009440 Genomic DNA. Translation: AAP98966.1 .
    PIRi D86615.
    G72009.
    RefSeqi NP_225193.1. NC_000922.1.
    NP_301054.1. NC_002491.1.
    NP_445393.1. NC_002179.2.
    NP_877309.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z6R0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0999.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19136 ; AAD19136 ; CPn_0999 .
    AAF38644 ; AAF38644 ; CP_0855 .
    AAP98966 ; AAP98966 ; CpB1037 .
    BAA99206 ; BAA99206 ; BAA99206 .
    GeneIDi 1467716.
    894682.
    919768.
    963295.
    KEGGi cpa:CP0855.
    cpj:CPj0999.
    cpn:CPn0999.
    cpt:CpB1037.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi RRIITHD.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-882-MONOMER.
    CPNE115713:GHEY-1043-MONOMER.
    CPNE138677:GH8N-1033-MONOMER.
    CPNE182082:GH4N-1072-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiPNP_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z6R0
    Secondary accession number(s): Q7AHZ1, Q7DE66, Q7VPR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3