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Q9Z6R0

- PNP_CHLPN

UniProt

Q9Z6R0 - PNP_CHLPN

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, CPn_0999, CP_0855, CpB1037
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861Magnesium By similarity
Metal bindingi492 – 4921Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-882-MONOMER.
CPNE115713:GHEY-1043-MONOMER.
CPNE138677:GH8N-1033-MONOMER.
CPNE182082:GH4N-1072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:CPn_0999, CP_0855, CpB1037
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329579Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0999.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6R0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KHAdd
BLAST
Domaini622 – 69069S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRRIITHD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z6R0-1 [UniParc]FASTAAdd to Basket

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MNFQTISINL TEGKILVFET GKIARQANGA VLVRSGETCV FASACAVDLD    50
DKVDFLPLRV DYQEKFSSTG KTLGGFIKRE GRPSEKEILV SRLIDRSLRP 100
SFPYRLMQDV QVLSYVWSYD GQVLPDPLAI CAASAALAIS DIPQSNIVAG 150
VRIGCIDNQW VINPTKTELA SSTLDLVLAG TENAILMIEG HCDFFTEEQV 200
LDAIEFGHKH IVTICKRLQL WQEEVGKSKN LSAVYPLPAE VLTAVKECAQ 250
DKFTELFNIK DKKVHAATAH EIEENILEKL QREDDDLFSS FNIKAACKTL 300
KSDTMRALIR DREIRADGRS LTTVRPITIE TSYLPRTHGS CLFTRGETQT 350
LAVCTLGSEA MAQRYEDLNG EGLSKFYLQY FFPPFSVGEV GRIGSPGRRE 400
IGHGKLAEKA LSHALPDSAT FPYTIRIESN ITESNGSSSM ASVCGGCLAL 450
MDAGVPISSP IAGIAMGLIL DDQGAIILSD ISGLEDHLGD MDFKIAGSGK 500
GITAFQMDIK VEGITPAIMK KALSQAKQGC NDILNIMNEA LSAPKADLSQ 550
YAPRIETMQI KPTKIASVIG PGGKQIRQII EETGVQIDVN DLGVVSISAS 600
SASAINKAKE IIEGLVGEVE VGKTYRGRVT SVVAFGAFVE VLPGKEGLCH 650
ISECSRQRIE NISDVVKEGD IIDVKLLSIN EKGQLKLSHK ATLE 694
Length:694
Mass (Da):75,347
Last modified:May 1, 1999 - v1
Checksum:i5D1D9C1E0DF9D62E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251V → I in AAP98966. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19136.1.
AE002161 Genomic DNA. Translation: AAF38644.1.
BA000008 Genomic DNA. Translation: BAA99206.1.
AE009440 Genomic DNA. Translation: AAP98966.1.
PIRiD86615.
G72009.
RefSeqiNP_225193.1. NC_000922.1.
NP_301054.1. NC_002491.1.
NP_445393.1. NC_002179.2.
NP_877309.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19136; AAD19136; CPn_0999.
AAF38644; AAF38644; CP_0855.
AAP98966; AAP98966; CpB1037.
BAA99206; BAA99206; BAA99206.
GeneIDi1467716.
894682.
919768.
963295.
KEGGicpa:CP0855.
cpj:CPj0999.
cpn:CPn0999.
cpt:CpB1037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19136.1 .
AE002161 Genomic DNA. Translation: AAF38644.1 .
BA000008 Genomic DNA. Translation: BAA99206.1 .
AE009440 Genomic DNA. Translation: AAP98966.1 .
PIRi D86615.
G72009.
RefSeqi NP_225193.1. NC_000922.1.
NP_301054.1. NC_002491.1.
NP_445393.1. NC_002179.2.
NP_877309.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6R0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19136 ; AAD19136 ; CPn_0999 .
AAF38644 ; AAF38644 ; CP_0855 .
AAP98966 ; AAP98966 ; CpB1037 .
BAA99206 ; BAA99206 ; BAA99206 .
GeneIDi 1467716.
894682.
919768.
963295.
KEGGi cpa:CP0855.
cpj:CPj0999.
cpn:CPn0999.
cpt:CpB1037.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi RRIITHD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-882-MONOMER.
CPNE115713:GHEY-1043-MONOMER.
CPNE138677:GH8N-1033-MONOMER.
CPNE182082:GH4N-1072-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiPNP_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6R0
Secondary accession number(s): Q7AHZ1, Q7DE66, Q7VPR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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