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Q9Z6Q0

- MAP1_CHLPN

UniProt

Q9Z6Q0 - MAP1_CHLPN

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Protein

Methionine aminopeptidase

Gene
map, CPn_1009, CP_0844, CpB1046
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Substrate By similarity
Metal bindingi135 – 1351Divalent metal cation 1 By similarity
Metal bindingi146 – 1461Divalent metal cation 1 By similarity
Metal bindingi146 – 1461Divalent metal cation 2; catalytic By similarity
Metal bindingi209 – 2091Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei216 – 2161Substrate By similarity
Metal bindingi241 – 2411Divalent metal cation 2; catalytic By similarity
Metal bindingi273 – 2731Divalent metal cation 1 By similarity
Metal bindingi273 – 2731Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-871-MONOMER.
CPNE115713:GHEY-1053-MONOMER.
CPNE138677:GH8N-1043-MONOMER.
CPNE182082:GH4N-1082-MONOMER.

Protein family/group databases

MEROPSiM24.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase (EC:3.4.11.18)
Short name:
MAP
Short name:
MetAP
Alternative name(s):
Peptidase M
Gene namesi
Name:map
Ordered Locus Names:CPn_1009, CP_0844, CpB1046
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Methionine aminopeptidaseUniRule annotationPRO_0000148933Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn1009.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6Q0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
HOGENOMiHOG000030427.
KOiK01265.
OMAiCQITARI.
OrthoDBiEOG6MWNDS.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01974. MetAP_1.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
IPR004027. SEC_C_motif.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
PF02810. SEC-C. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.
PROSITEiPS00680. MAP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z6Q0-1 [UniParc]FASTAAdd to Basket

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MKRNDPCWCG SGRKWKQCHY PQPPKMSPEA LKQHYASQYN ILLKTPEQKA    50
KIYNACQITA RILDELCKAS QKGVTTNELD ELSQELHKKY DAIAAPFHYG 100
SPPFPKTICT SLNEVICHGI PNDIPLKDGD IMNIDVSCIV DGYYGDCSRM 150
VMIGEVPEIK KKICQAALEC LNDSIAILKP GIPLCEIGEA IEARADTYGF 200
SVVDQFVGHG VGIEFHENPY VPHYRNRSMI PLAPGMIFTI EPMINVGKKE 250
GVVDPKNQWE ARTCDNQPSA QWEHTIAITE TGYEILTLLN D 291
Length:291
Mass (Da):32,596
Last modified:May 1, 1999 - v1
Checksum:i094F6D6E17F23DE9
GO

Sequence cautioni

The sequence AAF38634.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAP98976.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19146.1.
AE002161 Genomic DNA. Translation: AAF38634.1. Different initiation.
BA000008 Genomic DNA. Translation: BAA99216.1.
AE009440 Genomic DNA. Translation: AAP98976.1. Different initiation.
PIRiA81531.
E72008.
F86616.
RefSeqiNP_225203.1. NC_000922.1.
NP_301064.1. NC_002491.1.
NP_445382.2. NC_002179.2.
NP_877319.2. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19146; AAD19146; CPn_1009.
AAF38634; AAF38634; CP_0844.
AAP98976; AAP98976; CpB1046.
BAA99216; BAA99216; BAA99216.
GeneIDi1467726.
894643.
919776.
963127.
KEGGicpa:CP0844.
cpj:CPj1009.
cpn:CPn1009.
cpt:CpB1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19146.1 .
AE002161 Genomic DNA. Translation: AAF38634.1 . Different initiation.
BA000008 Genomic DNA. Translation: BAA99216.1 .
AE009440 Genomic DNA. Translation: AAP98976.1 . Different initiation.
PIRi A81531.
E72008.
F86616.
RefSeqi NP_225203.1. NC_000922.1.
NP_301064.1. NC_002491.1.
NP_445382.2. NC_002179.2.
NP_877319.2. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6Q0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn1009.

Protein family/group databases

MEROPSi M24.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19146 ; AAD19146 ; CPn_1009 .
AAF38634 ; AAF38634 ; CP_0844 .
AAP98976 ; AAP98976 ; CpB1046 .
BAA99216 ; BAA99216 ; BAA99216 .
GeneIDi 1467726.
894643.
919776.
963127.
KEGGi cpa:CP0844.
cpj:CPj1009.
cpn:CPn1009.
cpt:CpB1046.

Phylogenomic databases

eggNOGi COG0024.
HOGENOMi HOG000030427.
KOi K01265.
OMAi CQITARI.
OrthoDBi EOG6MWNDS.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-871-MONOMER.
CPNE115713:GHEY-1053-MONOMER.
CPNE138677:GH8N-1043-MONOMER.
CPNE182082:GH4N-1082-MONOMER.

Family and domain databases

Gene3Di 3.90.230.10. 1 hit.
HAMAPi MF_01974. MetAP_1.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
IPR004027. SEC_C_motif.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
PF02810. SEC-C. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 1 hit.
TIGRFAMsi TIGR00500. met_pdase_I. 1 hit.
PROSITEi PS00680. MAP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiMAP1_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6Q0
Secondary accession number(s): Q9JQD4, Q9K1X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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